Systems Biology pp 277-302
Modelling signalling pathways – a yeast approach
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MAP kinase pathways are conserved signalling systems in eukaryotes that control stress responses, cell growth, and proliferation, as well as differentiation. Here, we discuss and compare the feedback control mechanisms of two very well studied yeast signalling systems: the pheromone response pathway and the osmosensing HOG pathway. Mathematical models have recently been generated, allowing in silico analysis of signalling properties of both pathways. To advance our understanding of pathway control and to make modelling less dependent on parameter estimation, quantitative time course data of high precision and resolution need to be generated in the future and implemented into mathematical models. We expect that a combination of quantitative analyses and modelling/simulation will provide novel insight into the rules with which signalling pathways control cellular processes.
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