Abstract
The Cancer Institute (UPCI) at the University of Pittsburgh Medical Center (UPMC) contains two cellular therapy laboratories: the Hematopoietic Stem Cell Laboratory (HSC Lab) and Cellular Products Laboratory/Gene Therapy Laboratory (CPL/GTL). These facilities are responsible for the final development and manufacturing of biological products required for University investigator-initiated research protocols, external partnerships, and contracts for cellular product manufacturing. This chapter describes the design features of these two laboratories.
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References
Donnenberg AD. Good Manufacturing Practices (GMP) in a Hospital Environment: The Ideal and the Real. Cytotherapy. 2001; 3(2): 63–5.
McCullough J, Wagner J, Gee A, Rooney C, Whiteside T, Donnenberg A, Lindblad R. Production Assistance for Cellular Therapies. Transfusion. 2004; 44(12): 1793–5.
Donnenberg AD, Koch EK, Griffin DL, Stanczak HM, Kiss JE, Carlos TM, BuchBarker DM, Yeager AM. Viability of Cryopreserved Bone Marrow (BM) Progenitor Cells Stored for More Than a Decade. Cytotherapy. 2002; 4(2): 157–63.
Whiteside TL. Anti Tumor Vaccines in Head and Neck Cancer: Targeting Immune Responses to the Tumor. Curr Cancer Drug Targets. 2007 Nov; 7(7): 633–42. Review.
Okada H, Lieberman FS, Walter KA, Lunsford LD, Kondziolka DS, Bejjani GK, Hamilton RL, Torres-Trejo A, Kalinski P, Cai Q, Mabold JL, Edington HD, Butterfield LH, Whiteside TL, Potter DM, Schold SC Jr, Pollack IF. Autologous Glioma Cell Vaccine Admixed with Interleukin-4 Gene Transfected Fibroblasts in the Treatment of Patients with Malignant Gliomas. J Transl Med. 2007 Dec 19; 5: 67.
Whiteside TL. Immune Monitoring of Clinical Trials with Biotherapies. Adv Clin Chem. 2008; 45: 75–97.
Whiteside TL. Evaluation of Dendritic Cell Products Generated for Human Therapy and Post- Treatment Immune Monitoring. BioPharm Int Suppl. Advances in Vaccine Development & Manufacturing. 2008 March; 21: 2–17.
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Griffin, D., Donnenberg, A., Whiteside, T. (2009). University of Pittsburgh Cancer Institute - Hematopoietic Stem Cell Laboratory (HSC Lab)/Immunological Monitoring and Cellular Products Laboratory (IMCPL). In: Gee, A. (eds) Cell Therapy. Springer, Boston, MA. https://doi.org/10.1007/b102110_5
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DOI: https://doi.org/10.1007/b102110_5
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