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Shear effects on suspended cells

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Book cover Bioreactor Systems and Effects

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 44))

Abstract

Shear has been mainly considered in the technical literature as a destructive element, when applied to microorganisms and cells. Indeed, most of the research work addressing the subject aims at the identification of damaging levels of shear on a given culture. The present work is focused on the effects of shear on suspended cultures before the damaging levels are attained. Inspection of the literature reveals that shear may influence growth rate, cellular volume, metabolite production rate and distribution, and membrane permeabilities. Available devices for study and evaluation of shear effects on suspended cultures are described and critically reviewed.

The review reveals the possibility of an influence of the liquid dynamics on the kinetics of the biochemical process. This is relevant for bioreactor design and scale up, and stresses the importance of using structural bioreactor models in order to describe the hydrodynamics of the system.

This review is based on lectures presented by the author at the University College, London, on July 1988

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Authors and Affiliations

  1. Department of Chemical Engineering, Ben Gurion University of the Negev, 84105, Beer Sheva, Israel

    Jose Celman Merchuk

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  1. Jose Celman Merchuk
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© 1991 Springer-Verlag

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Merchuk, J.C. (1991). Shear effects on suspended cells. In: Bioreactor Systems and Effects. Advances in Biochemical Engineering/Biotechnology, vol 44. Springer, Berlin, Heidelberg. https://doi.org/10.1007/Bfb0000748

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  • DOI: https://doi.org/10.1007/Bfb0000748

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  • Print ISBN: 978-3-540-54094-6

  • Online ISBN: 978-3-540-47400-5

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