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Chemical and biochemical aspects of deoxysugars and deoxysugar oligosaccharides

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Bioorganic Chemistry Deoxysugars, Polyketides and Related Classes: Synthesis, Biosynthesis, Enzymes

Part of the book series: Topics in Current Chemistry ((4143,volume 188))

Abstract

Deoxysugars and the oligosaccharides derived from them belong to one of the most important, but often most neglected, group of biological compounds. As a result of important recent progress in their chemical synthesis as well as insights into their various biochemical aspects, one can expect a major boom in the amount of research devoted to this promising field. In this chapter, the most significant aspects of the biochemistry and chemistry of deoxysugars and deoxysugar-containing oligosaccharides are discussed: (1) biosynthetic, biochemical, and molecular biological studies, including deoxygenation mechanisms, glycosyl transfer, and genes involved in biosynthesis; (2) recent experiments aimed at determining how monoor oligosaccharide moieties of bioactive natural products contribute to biological activity, i. e., the mode of action of these compounds; and (3) synthetic aspects such as chemical glycosidation and enzymatic methods for the construction of deoxysugar oligosaccharides. The information presented here is based on literature published until mid-1996.

Dedicated to Heinz G. Floss.

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Authors and Affiliations

  1. Institut für Organische Chemie, Technische Universität Clausthal, Leibnizstraße 6, 38678, Clausthal-Zellerfeld, Germany

    Andreas Kirschning

  2. Institut für Pharmazeutische Biologie, Universität Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany

    Andreas F. -W. Bechthold

  3. Institut für Organische Chemie, Universität Göttingen, Tammannstraße 2, 37077, Göttingen, Germany

    Jürgen Rohr

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  1. Andreas Kirschning
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  2. Andreas F. -W. Bechthold
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  3. Jürgen Rohr
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Correspondence to Andreas Kirschning , Andreas F. -W. Bechthold or Jürgen Rohr .

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Jürgen Rohr

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© 1997 Springer-Verlag Berlin Heidelberg

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Kirschning, A., Bechthold, A.F.W., Rohr, J. (1997). Chemical and biochemical aspects of deoxysugars and deoxysugar oligosaccharides. In: Rohr, J. (eds) Bioorganic Chemistry Deoxysugars, Polyketides and Related Classes: Synthesis, Biosynthesis, Enzymes. Topics in Current Chemistry, vol 188. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0119234

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  • DOI: https://doi.org/10.1007/BFb0119234

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