Renin and hypertensin

  • W. S. Peart
Conference paper
Part of the Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie book series (ERGEBPHYSIOL, volume 50)


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Armstrong, D., R. M. L. Dry, C. A. Keele andJ. W. Markham: Pain-producing substances in blister fluid and in serum. J. Physiol. (Lond.)117, 4p. (1952).Google Scholar
  2. Armstrong, D., J. B. Jepson, C. A. Keele andJ. W. Stewart: Activation by glass of pharmacologically active agents in blood of various species. J. Physiol. (Lond.)129, 80p. (1955).Google Scholar
  3. Blacket, R. B., A. Depoorter, G. W. Pickering, A. L. Sellers andG. M. Wilson: Hypertension produced in the rabbit by long continued infusions of renin. Clin. Sci.9, 223 (1950).Google Scholar
  4. Bock, K. D., H. Dengler, H.-J. Krecke u.G. Reichel: Untersuchungen über die Wirkung von synthetischem Hypertensin II auf Elektrolythaushalt, Nierenfunktion und Kreislauf beim Menschen. Klin. Wschr.36, 808 (1958) (b).PubMedCrossRefGoogle Scholar
  5. —, u.H.-J. Krecke: Die Wirkung von synthetischem Hypertensin II auf die PAH und Inulin-Clearance, die renale Hämodynamik und die Diurese beim Menschen. Klin. Wschr.36, 69 (1958).PubMedCrossRefGoogle Scholar
  6. Bock, K. D., H. J. Krecke u.H. M. Kuhn: Untersuchungen über die Wirkung von synthetischem Hypertensin II auf Blutdruck, Atmung und Extremitätendurchblutung des Menschen. Klin. Wschr.36, 254 (1958) (a).PubMedCrossRefGoogle Scholar
  7. Bradley, S. E., andB. Parker: The hemodynamic effects of angiotonin in normal man. J. clin. Invest.20, 715 (1941).PubMedCrossRefGoogle Scholar
  8. Braun-Menéndez, E.: Pharmacology of renin and hypertensin. Pharmacol. Rev.8, 25 (1956).PubMedGoogle Scholar
  9. —,J. C. Fasciolo, L. F. Leloir yJ. M. Muñoz: La substancia hipertensora de la sangre del riñon isquemiado. Rev. Soc. argent. Biol.15, 420 (1939).Google Scholar
  10. ———— andA. C. Taquini: Renal hypertension. Springfield, Ill.: Thomas 1946.Google Scholar
  11. —, andI. H. Page: Suggested revision of nomenclature-angiot ensin. Science127, 242 (1958).PubMedCrossRefGoogle Scholar
  12. Brewin, E. G., R. A. Kenney andD. H. Miller: Pressor effect of renin on pulmonary artery pressure. Nature (Lond.)161, 893 (1948).CrossRefGoogle Scholar
  13. Bumpus, F. M., H. Schwarz andI. H. Page: Synthesis and pharmacology of the octapeptide angiotonin. Science125, 886 (1957).PubMedCrossRefGoogle Scholar
  14. Collins, D. A., andA. S. Hamilton: Pressor responses following short, complete renal ischemia: characteristics, mechanism, specificity for kidney. Amer. J. Physiol.130, 784 (1940).Google Scholar
  15. ——: Changes in the renin-angiotonin system in hemorrhagic shock. Amer. J. Physiol.140, 499 (1944).Google Scholar
  16. Cook, W., D. B. Gordon andW. S. Peart: The location of renin in the rabbit kidney. J. Physiol. (Lond.)135, 46p. (1957).Google Scholar
  17. —, andG. W. Pickering: A rapid method for separating glomeruli from rabbit kidney. Nature (Lond.)182, 1103 (1958).CrossRefGoogle Scholar
  18. Croxatto, H., andR. Croxatto: “Pepsitensin”-hypertensinlike substance produced by peptic digestion of proteins. Science95, 101 (1942).PubMedCrossRefGoogle Scholar
  19. Daniel, P. M., M. M. L. Prichard andJ. N. Ward-McQuaid: Removal of the clip on the renal artery in rabbits with experimental chronic hypertension. Quart. J. exp. Physiol.39, 101 (1954) (a).PubMedGoogle Scholar
  20. ———: Total nephrectomy in rabbits with chronic hypertension. Clin. Sci.13, 247 (1954) (b).PubMedGoogle Scholar
  21. ———: The renal circulation in experimental hypertension: angiographic and morphological studies in the rabbit. Brit. J. Surg.42, 81 (1954) (c).PubMedCrossRefGoogle Scholar
  22. ———: An angiographic study of the effect of renin upon the renal circulation. J. Physiol. (Lond.)124, 106 (1954) (d).Google Scholar
  23. Dell’Oro, E., yE. Braun-Menéndez: Dosaje de renina en la sangre de perros hipertensos por isquemia renal. Rev. Soc. argent. Biol.18, 65 (1942).Google Scholar
  24. Dexter, L., andF. W. Haynes: Relation of renin to human hypertension with particular reference to eclampsia, preeclampsia and acute glomerulonephritis. Proc. Soc. exp. Biol. (N. Y.)55, 288 (1944).Google Scholar
  25. Drury, D. R., J. Flasher, D. B. Gordon andM. E. Dorough: Renin substrate and renal hypertension, including a one-stage method for evisceration in the rabbit. Amer. J. Physiol.164, 630 (1951).PubMedGoogle Scholar
  26. Elliott, D. F., andW. S. Peart: Amino-acid sequence in a hypertensin. Nature (Lond.)177, 527 (1956).CrossRefGoogle Scholar
  27. ——: The amino acid sequence in a hypertensin. Biochem. J.65, 246 (1957).PubMedGoogle Scholar
  28. Fasciolo, J. C., L. F. Leloir, J. M. Muñoz andE. Braun-Menéndez: On the specificity of renin. Science92, 554 (1940).PubMedCrossRefGoogle Scholar
  29. —, yA. C. Taquini: Método para el reconocimiento de pequenas cantidades de renina. Rev. Soc. argent. Biol.23, 138 (1947).Google Scholar
  30. Flasher, J., andD. R. Drury: Relationship of renin to early renal hypertension in the rabbit. Amer. J. Physiol.162, 385 (1950).PubMedGoogle Scholar
  31. Friedberg, L., L. N. Katz andF. S. Steinitz: The effect of drugs on the pulmonary and systemic arterial pressures in the trained unanaesthetised dog. J. Pharmacol. (Kyoto)77, 80 (1943).Google Scholar
  32. Friedman, M., andA. Kaplan: Studies concerning the site of renin formation in the kidney. IV. The renin content of the mammalian kidney following specific necrosis of proximal convoluted tubular epithelium. J. exp. Med.77, 65 (1943).PubMedCrossRefGoogle Scholar
  33. Gaddum, J. H., W. S. Peart andM. Vogt: The estimation of adrenaline and allied substances in blood. J. Physiol. (Lond.)108, 467 (1949).Google Scholar
  34. Goldblatt, H.: Experimental renal hypertension: mechanism of production and maintenance. Circulation17, Part 2, 642 (1958) (a).PubMedGoogle Scholar
  35. —: Discussion in Conference on Renal Pressor System. Circulation17, Part 2, 688 (1958) (b).Google Scholar
  36. —,E. Haas andH. Lamfrom: Antirenin in man and animals. Trans. Ass. Amer. Phycns64, 122 (1951).Google Scholar
  37. —,Y. J. Katz, H. A. Lewis andE. Richardson: Studies on experimental hypertension. XX. The bioassay of renin. J. exp. Med.77, 309 (1943).PubMedCrossRefGoogle Scholar
  38. Goldenberg, M., H. Aranow, A. A. Smith andM. Faber: Phaeochromocytoma and essential hypertensive vascular disease. Arch. intern. Med.86, 823 (1950).Google Scholar
  39. Gollan, F., R. Richardson andH. Goldblatt: Hypertensin in the systemic blood of animals with experimental renal hypertension. J. exp. Med.88, 389 (1948).PubMedCrossRefGoogle Scholar
  40. Goormaghtigh, N.: The renal arteriolar changes in the anuric crush syndrome. Amer. J. Path.23, 513 (1947).PubMedGoogle Scholar
  41. Govaerts, P., etA. Verniory: Recherches sur le pouvoir vasoconstricteur du sang de la veine cave inférieure dans l’hypertension chronique d’origine rénale, chez le chien. Bull. Acad. roy. Méd. Belg.14, 325 (1949).Google Scholar
  42. ——: The vasoconstrictor properties of the vena cava blood of dogs with acute and chronic renal hypertension. Acta med. scand., Suppl.266, 419 (1952).Google Scholar
  43. —— etJ. Lebrun: Recherches sur les relations entre la réactivité a la rénine et l’hypertension rénale expérimentale chez le chien. Bull. Acad. roy. Méd. Belg.15, 375 (1950).Google Scholar
  44. Green, A. A., andF. M. Bumpus: The purification of hog renin substrate. J. biol. Chem.210, 281 (1954).PubMedGoogle Scholar
  45. Gross, F., andF. Sulser: Influence of the adrenals on the hypertensive effects of renin, and on pressor substances in the kidneys. Arch. exp. Path. Berl.230, 274 (1957).Google Scholar
  46. Haas, E., H. Lamfrom andH. Goldblatt: Isolation and purification of hog renin. Arch. Biochem.42, 368 (1953).PubMedCrossRefGoogle Scholar
  47. ———: A simple method for the extraction and partial purification of renin. Arch. Biochem.48, 256 (1954).PubMedCrossRefGoogle Scholar
  48. Hamilton, M., J. W. Litchfield, W. S. Peart andG. S. C. Sowry: Phaeochromocytoma. Brit. Heart J.15, No 2, 241 (1953).PubMedCrossRefGoogle Scholar
  49. Haynes, F. W., L. Dexter andR. E. Seibel: Renin content of renal venous blood of normal and hypertensive patients at rest. Amer. J. Physiol.150, 198 (1947).PubMedGoogle Scholar
  50. Helmer, O.: A factor in plasma that enhances contraction produced by angiotonin on rabbit aortic strips. Fed. Proc.14, 728 (1955).Google Scholar
  51. —: Studies on renin antibodies. Circulation17, 648 (1958).PubMedGoogle Scholar
  52. —, andR. M. Sanders: Differentiation between two forms of angiotonin by means of spirally cut strips of rabbit aorta. Amer. J. Physiol.188, 571 (1957).PubMedGoogle Scholar
  53. Johnson, C. A., andG. E. Wakerlin: Antiserum for renin. Proc. Soc. exp. Biol. (N.Y.)44, 277 (1940).Google Scholar
  54. Kremen, S. H., andG. E. Wakerlin: Renin and antirenin in treatment of long term experimental renal hypertension in the dog. Proc. Soc. exp. Biol. (N. Y.)90, 99 (1955).Google Scholar
  55. Lamfrom, H., E. Haas andH. Goldblatt: Studies on antirenin. Amer. J. Physiol.177, 55 (1954).PubMedGoogle Scholar
  56. Leloir, L. F., J. M. Muñoz, A. C. Taquini, E. Braun-Menéndez y.J. C. Fasciolo La formación del hipertensinogeno. Rev. argent. Cardiol.9, 269 (1942).Google Scholar
  57. Lewis, H. A., S. D. Leo andM. Prinzmetal: The effect of re-establishment of circulation in completely ischemic kidneys upon the blood pressure of cats, dogs and rats. Amer. Heart J.21, 319 (1941).CrossRefGoogle Scholar
  58. Ludueña, F. P.: Acción de los preparados de hipertensina sobre los músculos lisos. Rev. Soc. argent. Biol.16, 358 (1940).Google Scholar
  59. Margolin, E. G., J. P. Merrill andJ. H. Harrison: Diagnosis of hypertension due to occlusions of the renal artery. New Engl. J. Med.256, 581 (1957).PubMedCrossRefGoogle Scholar
  60. Meier, R., F. Gross, J. Tripod u.H. Turrian: Pharmakologische Charakterisierung von synthetischem Hypertensin. Experientia (Basel)13, 361 (1957).CrossRefGoogle Scholar
  61. Merrill, A. J., J. L. Morrison andE. S. Brannon: Concentration of renin in renal venous blood in patients with chronic heart failure. Amer. J. Med.1, 468 (1946).PubMedCrossRefGoogle Scholar
  62. Nelson, R. A., L. G. May, A. Bennett, M. Kobayashi andR. Gregory: Comparison of the effects of pressor and depressor agents and influences on pulmonary and systemic pressures of normotensive and hypertensive subjects. Amer. Heart J.50, 172 (1955).PubMedCrossRefGoogle Scholar
  63. Page, I. H., andO. M. Helmer: A crystalline pressor substance (angiotonin) resulting from the reaction between renin and renin-activator. J. exp. Med.71, 29 (1940).PubMedCrossRefGoogle Scholar
  64. Peart, W. S.: The nature of splenic sympathin. J. Physiol. (Lond.)108, 491 (1949).Google Scholar
  65. —: Ciba Foundation Symposium on Hypertension. Humoral and neurogenic factors, p. 104. London: Churchill 1954.Google Scholar
  66. —: A new method of large-scale preparation of hypertensin, with a note on its assay. Biochem. J.59, 300 (1955) (a).PubMedGoogle Scholar
  67. —: The purification of hypertensin. Biochem. J.60, vi (1955) (b).PubMedGoogle Scholar
  68. —: The isolation of a hypertensin. Biochem. J.62, 520 (1956).PubMedGoogle Scholar
  69. Peart, W. S.: Lecture on “Some biochemical aspects of hypertension” in the Basis of Scientific Medicine.1, 182: Athlone Press 1959.Google Scholar
  70. Peart, W. S., andD. Sutton: Renal vein catheterisation and venography: a new technique. Lancet1958, 817.Google Scholar
  71. Peterson, E. A., andH. A. Sober: Chromatography of proteins. 1. Cellulose ionexchange adsorbents. J. Amer. chem. Soc.78, 751 (1956).CrossRefGoogle Scholar
  72. Picarelli, Z. P., R. Kupper, E. S. Prado andJ. R. Valle: Assay of renin and hypertensin with the isolated guinea-pig ileum. Circulat. Res.2, 354 (1954).PubMedGoogle Scholar
  73. Pickering, G. W.: The role of the kidney in acute and chronic hypertension following renal artery constriction in the rabbit. Clin. Sci.5, 229 (1945).PubMedGoogle Scholar
  74. —, andM. Prinzmetal: Some observations on renin, a pressor substance contained in normal kidney, together with a method for its biological assay. Clin. Sci.3, 211 (1938).Google Scholar
  75. —— andA. R. Kelsall: The assay of renin in rabbits with experimental renal hypertension. Clin. Sci.4, 401 (1942).Google Scholar
  76. Porath, J.: Methodological studies of zone-electrophoresis in vertical columns. 1. Fractionation in cellulose powder columns of substances of low molecular weight exemplified by amino acids and related compounds. Biochim. biophys. Acta22, 151 (1956).PubMedCrossRefGoogle Scholar
  77. Prinzmetal, M., H. Lewis andS. Leo: Etiology of hypertension due to complete renal ischemia. Proc. Soc. exp. Biol. (N.Y.)43, 696 (1940).Google Scholar
  78. ———: Etiology of hypertension due to complete renal ischemia. J. exp. Med.72, 763 (1940).PubMedCrossRefGoogle Scholar
  79. ——,J. Taggart, H. Williams andD. R. Drury: The effect of transplanted ischemic kidneys and of temporary, complete, renal ischemia upon the blood pressure of rabbits. Amer. Heart J.20, 525 (1940).CrossRefGoogle Scholar
  80. Quinby, W. C., L. Dexter, J. A. Sandmeyer andF. W. Haynes: The effect of transitory complete constriction of the human renal artery on blood pressure and on the concentration of renin, hypertensinogen and hypertensinase of renal arterial and venous blood, with animal observations. J. clin. Invest.24, 69 (1945).PubMedCrossRefGoogle Scholar
  81. Reid, G., andH. A. Jenkins: The action of renin and hypertensin on the pulmonary and hepatic circulations. Aust. J. exp. Biol. med. Sci.26, 81 (1948).PubMedCrossRefGoogle Scholar
  82. Sapirstein, L. A.: Sodium and water ratios in the pathogenesis od hypertension. Hypertension, Vol. VI, Mineral Metabolism. Proceedings of the Council for High Blood Pressure Research. Amer. Heart Assoc., November 1957, p. 28.Google Scholar
  83. Schwarz, H., andI. H. Page: Assay of angiotonin on isolated rat uterus. Fed. Proc.13, 293 (1954).Google Scholar
  84. Schwyzer, R., W. Rittel, B. Iselin, H. Kappeler u.B. Riniker: Synthese eines hochwirksamen Hypertensin II-Amids. Helv. chim. Acta40, 614 (1957) (a).CrossRefGoogle Scholar
  85. —————: Synthese von Hypertensin-II-Peptiden. Angew. Chem.69, 179 (1957) (b).CrossRefGoogle Scholar
  86. ————— u.H. Zuber: Synthese von Hypertensin peptiden. Über die partielle Hydrolyse von Hypertensin-asp-β-Amiden zu den entsprechenden Dicarbonsäuren. Hypertensin-II-Analoge. Chimia11, 335 (1957) (c).Google Scholar
  87. ——————: Val5-Hypertensin I und II. Chimia12, 91 (1958) (a).Google Scholar
  88. ——————: Synthese hochwirksamer Dekapeptide mit der Aminosäure-Sequenz des val5-Hypertensins I. Helv. chim. Acta41, 1273 (1958) (b).CrossRefGoogle Scholar
  89. ——————: Synthese hochwirksamer Oktapeptide mit der vermutlichen Aminosäuresequenz des noch unbekannten Hypertensins II aus Rinderserum (val5-Hypertensin II und val5-Hypertensin II-asp-β-Amid). Helv. chim. Acta41, 1287 (1958) (c).CrossRefGoogle Scholar
  90. —, u.P. Sieber: Neuere Synthesen auf dem Peptidgebiet. Chimia10, 265 (1956).Google Scholar
  91. Skeggs, L. T., J. R. Kahn, K. E. Lentz andN. P. Shumway: The preparation, purification and amino-acid sequence of a polypeptide renin substrate. J. exp. Med.106, 439 (1957).PubMedCrossRefGoogle Scholar
  92. —— andN. P. Shumway: The isolation of hypertensin from circulating blood of normal dogs with experimental hypertension by dialysis in the artificial kidney. Circulation3, 384 (1951).PubMedGoogle Scholar
  93. ———: The isolation and assay of hypertensin from blood. J. exp. Med.95, 241 (1952).PubMedCrossRefGoogle Scholar
  94. ———: The preparation and function of the hypertensin converting enzyme. J. exp. Med.103, 295 (1956) (a).PubMedCrossRefGoogle Scholar
  95. —,K. E. Lentz, J. R. Kahn andN. P. Shumway: The synthesis of a tetradecapeptide renin substrate. J. exp. Med.108, 283 (1958).PubMedCrossRefGoogle Scholar
  96. ———— andK. R. Woods: Amino-acid sequence of hypertensin II. J. exp. Med.104, 193 (1956) (b).PubMedCrossRefGoogle Scholar
  97. —,W. H. Marsh, J. R. Kahn andN. P. Shumway: The existence of two forms of hypertensin. J. exp. Med.99, 275 (1954) (a).PubMedCrossRefGoogle Scholar
  98. ————: The purification of hypertensin I. J. exp. Med.100, 363 (1954) (b).PubMedCrossRefGoogle Scholar
  99. ————: Amino-acid composition and electrophoretic properties of hypertensin I. J. exp. Med.102, 435 (1955).PubMedCrossRefGoogle Scholar
  100. Smithies, O.: Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. Biochem. J.61, 629 (1955).PubMedGoogle Scholar
  101. Sober, H. A., F. J. Gutter, M. M. Wyckoff andE. A. Peterson: Chromatography of proteins. II. Fractionation of serum protein on anion-exchange cellulose. J. Amer. chem. Soc.78, 756 (1956).CrossRefGoogle Scholar
  102. Taggart, J., andD. R. Drury: The action of renin on rabbits with renal hypertension. J. exp. Med.71, 857 (1940).PubMedCrossRefGoogle Scholar
  103. Taquini, A. C.: Liberación de substancia hipertensora en el riñon completamente isquemiado. Rev. Soc. argent. Biol.14, 422 (1938).Google Scholar
  104. —: Production de substance hypertensive par le rein ischémié. C.R. Soc. Biol. (Paris)130, 459 (1939).Google Scholar
  105. —: The production of a pressor substance by the totally ischemic kidney. Amer. Heart J.19, 513 (1940).CrossRefGoogle Scholar
  106. —, yE. Braun-Menéndez: Liberación de la renina por el riñon totalmente isquemiado. Rev. Soc. argent. Biol.17, 465 (1941).Google Scholar
  107. —, andJ. C. Fasciolo: Renin in essential hypertension. Amer. Heart J.32, 357 (1946).PubMedCrossRefGoogle Scholar
  108. Taquini, A. C., J. C. Fasciolo yD. F. Luna: El lugar de formacion de la renina dentro deo rinon. Medicina (B. Aires)10, 174 (1950).Google Scholar
  109. Tigerstedt, R., undP. C. Bergman: Niere und Kreislauf. Skand. Arch. Physiol.8, 223 (1898).Google Scholar
  110. Wakerlin, G. E.: Antibodies to renin as proof of the pathogenesis of sustained renal hypertension. Circulation17, 653 (1958).PubMedGoogle Scholar
  111. —,R. B. Bird, B. B. Brennon, M. H. Frank, S. Kremen, I. Kuperman andJ. H. Skon: Treatment and prophylaxis of experimental renal hypertension with renin. J. Lab. clin. Med.41, 708 (1953).PubMedGoogle Scholar
  112. Yoshimura, F., andK. Shindo: The possible sites of renin formation in the kidneys of the experimental hypertensive rabbits. Endocr. jap.2, 117 (1955).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1959

Authors and Affiliations

  • W. S. Peart
    • 1
  1. 1.St. Mary’s HospitalLondon

Personalised recommendations