Skip to main content
SpringerLink
Log in

Renin and hypertensin

  • Conference paper
  • First Online:
Ergebnisse der physiologie biologischen chemie und experimentellen pharmakologie

Part of the book series: Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie ((ERGEBPHYSIOL,volume 50))

  • 23 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Armstrong, D., R. M. L. Dry, C. A. Keele andJ. W. Markham: Pain-producing substances in blister fluid and in serum. J. Physiol. (Lond.)117, 4p. (1952).

    Google Scholar 

  • Armstrong, D., J. B. Jepson, C. A. Keele andJ. W. Stewart: Activation by glass of pharmacologically active agents in blood of various species. J. Physiol. (Lond.)129, 80p. (1955).

    Google Scholar 

  • Blacket, R. B., A. Depoorter, G. W. Pickering, A. L. Sellers andG. M. Wilson: Hypertension produced in the rabbit by long continued infusions of renin. Clin. Sci.9, 223 (1950).

    Google Scholar 

  • Bock, K. D., H. Dengler, H.-J. Krecke u.G. Reichel: Untersuchungen über die Wirkung von synthetischem Hypertensin II auf Elektrolythaushalt, Nierenfunktion und Kreislauf beim Menschen. Klin. Wschr.36, 808 (1958) (b).

    Article  PubMed  CAS  Google Scholar 

  • —, u.H.-J. Krecke: Die Wirkung von synthetischem Hypertensin II auf die PAH und Inulin-Clearance, die renale Hämodynamik und die Diurese beim Menschen. Klin. Wschr.36, 69 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Bock, K. D., H. J. Krecke u.H. M. Kuhn: Untersuchungen über die Wirkung von synthetischem Hypertensin II auf Blutdruck, Atmung und Extremitätendurchblutung des Menschen. Klin. Wschr.36, 254 (1958) (a).

    Article  PubMed  CAS  Google Scholar 

  • Bradley, S. E., andB. Parker: The hemodynamic effects of angiotonin in normal man. J. clin. Invest.20, 715 (1941).

    Article  PubMed  CAS  Google Scholar 

  • Braun-Menéndez, E.: Pharmacology of renin and hypertensin. Pharmacol. Rev.8, 25 (1956).

    PubMed  Google Scholar 

  • —,J. C. Fasciolo, L. F. Leloir yJ. M. Muñoz: La substancia hipertensora de la sangre del riñon isquemiado. Rev. Soc. argent. Biol.15, 420 (1939).

    Google Scholar 

  • ———— andA. C. Taquini: Renal hypertension. Springfield, Ill.: Thomas 1946.

    Google Scholar 

  • —, andI. H. Page: Suggested revision of nomenclature-angiot ensin. Science127, 242 (1958).

    Article  PubMed  Google Scholar 

  • Brewin, E. G., R. A. Kenney andD. H. Miller: Pressor effect of renin on pulmonary artery pressure. Nature (Lond.)161, 893 (1948).

    Article  CAS  Google Scholar 

  • Bumpus, F. M., H. Schwarz andI. H. Page: Synthesis and pharmacology of the octapeptide angiotonin. Science125, 886 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Collins, D. A., andA. S. Hamilton: Pressor responses following short, complete renal ischemia: characteristics, mechanism, specificity for kidney. Amer. J. Physiol.130, 784 (1940).

    Google Scholar 

  • ——: Changes in the renin-angiotonin system in hemorrhagic shock. Amer. J. Physiol.140, 499 (1944).

    CAS  Google Scholar 

  • Cook, W., D. B. Gordon andW. S. Peart: The location of renin in the rabbit kidney. J. Physiol. (Lond.)135, 46p. (1957).

    Google Scholar 

  • —, andG. W. Pickering: A rapid method for separating glomeruli from rabbit kidney. Nature (Lond.)182, 1103 (1958).

    Article  CAS  Google Scholar 

  • Croxatto, H., andR. Croxatto: “Pepsitensin”-hypertensinlike substance produced by peptic digestion of proteins. Science95, 101 (1942).

    Article  PubMed  CAS  Google Scholar 

  • Daniel, P. M., M. M. L. Prichard andJ. N. Ward-McQuaid: Removal of the clip on the renal artery in rabbits with experimental chronic hypertension. Quart. J. exp. Physiol.39, 101 (1954) (a).

    PubMed  CAS  Google Scholar 

  • ———: Total nephrectomy in rabbits with chronic hypertension. Clin. Sci.13, 247 (1954) (b).

    PubMed  CAS  Google Scholar 

  • ———: The renal circulation in experimental hypertension: angiographic and morphological studies in the rabbit. Brit. J. Surg.42, 81 (1954) (c).

    Article  PubMed  CAS  Google Scholar 

  • ———: An angiographic study of the effect of renin upon the renal circulation. J. Physiol. (Lond.)124, 106 (1954) (d).

    CAS  Google Scholar 

  • Dell’Oro, E., yE. Braun-Menéndez: Dosaje de renina en la sangre de perros hipertensos por isquemia renal. Rev. Soc. argent. Biol.18, 65 (1942).

    Google Scholar 

  • Dexter, L., andF. W. Haynes: Relation of renin to human hypertension with particular reference to eclampsia, preeclampsia and acute glomerulonephritis. Proc. Soc. exp. Biol. (N. Y.)55, 288 (1944).

    CAS  Google Scholar 

  • Drury, D. R., J. Flasher, D. B. Gordon andM. E. Dorough: Renin substrate and renal hypertension, including a one-stage method for evisceration in the rabbit. Amer. J. Physiol.164, 630 (1951).

    PubMed  CAS  Google Scholar 

  • Elliott, D. F., andW. S. Peart: Amino-acid sequence in a hypertensin. Nature (Lond.)177, 527 (1956).

    Article  CAS  Google Scholar 

  • ——: The amino acid sequence in a hypertensin. Biochem. J.65, 246 (1957).

    PubMed  CAS  Google Scholar 

  • Fasciolo, J. C., L. F. Leloir, J. M. Muñoz andE. Braun-Menéndez: On the specificity of renin. Science92, 554 (1940).

    Article  PubMed  CAS  Google Scholar 

  • —, yA. C. Taquini: Método para el reconocimiento de pequenas cantidades de renina. Rev. Soc. argent. Biol.23, 138 (1947).

    CAS  Google Scholar 

  • Flasher, J., andD. R. Drury: Relationship of renin to early renal hypertension in the rabbit. Amer. J. Physiol.162, 385 (1950).

    PubMed  CAS  Google Scholar 

  • Friedberg, L., L. N. Katz andF. S. Steinitz: The effect of drugs on the pulmonary and systemic arterial pressures in the trained unanaesthetised dog. J. Pharmacol. (Kyoto)77, 80 (1943).

    CAS  Google Scholar 

  • Friedman, M., andA. Kaplan: Studies concerning the site of renin formation in the kidney. IV. The renin content of the mammalian kidney following specific necrosis of proximal convoluted tubular epithelium. J. exp. Med.77, 65 (1943).

    Article  PubMed  CAS  Google Scholar 

  • Gaddum, J. H., W. S. Peart andM. Vogt: The estimation of adrenaline and allied substances in blood. J. Physiol. (Lond.)108, 467 (1949).

    CAS  Google Scholar 

  • Goldblatt, H.: Experimental renal hypertension: mechanism of production and maintenance. Circulation17, Part 2, 642 (1958) (a).

    PubMed  CAS  Google Scholar 

  • —: Discussion in Conference on Renal Pressor System. Circulation17, Part 2, 688 (1958) (b).

    Google Scholar 

  • —,E. Haas andH. Lamfrom: Antirenin in man and animals. Trans. Ass. Amer. Phycns64, 122 (1951).

    CAS  Google Scholar 

  • —,Y. J. Katz, H. A. Lewis andE. Richardson: Studies on experimental hypertension. XX. The bioassay of renin. J. exp. Med.77, 309 (1943).

    Article  PubMed  CAS  Google Scholar 

  • Goldenberg, M., H. Aranow, A. A. Smith andM. Faber: Phaeochromocytoma and essential hypertensive vascular disease. Arch. intern. Med.86, 823 (1950).

    CAS  Google Scholar 

  • Gollan, F., R. Richardson andH. Goldblatt: Hypertensin in the systemic blood of animals with experimental renal hypertension. J. exp. Med.88, 389 (1948).

    Article  PubMed  CAS  Google Scholar 

  • Goormaghtigh, N.: The renal arteriolar changes in the anuric crush syndrome. Amer. J. Path.23, 513 (1947).

    PubMed  CAS  Google Scholar 

  • Govaerts, P., etA. Verniory: Recherches sur le pouvoir vasoconstricteur du sang de la veine cave inférieure dans l’hypertension chronique d’origine rénale, chez le chien. Bull. Acad. roy. Méd. Belg.14, 325 (1949).

    CAS  Google Scholar 

  • ——: The vasoconstrictor properties of the vena cava blood of dogs with acute and chronic renal hypertension. Acta med. scand., Suppl.266, 419 (1952).

    Google Scholar 

  • —— etJ. Lebrun: Recherches sur les relations entre la réactivité a la rénine et l’hypertension rénale expérimentale chez le chien. Bull. Acad. roy. Méd. Belg.15, 375 (1950).

    Google Scholar 

  • Green, A. A., andF. M. Bumpus: The purification of hog renin substrate. J. biol. Chem.210, 281 (1954).

    PubMed  CAS  Google Scholar 

  • Gross, F., andF. Sulser: Influence of the adrenals on the hypertensive effects of renin, and on pressor substances in the kidneys. Arch. exp. Path. Berl.230, 274 (1957).

    CAS  Google Scholar 

  • Haas, E., H. Lamfrom andH. Goldblatt: Isolation and purification of hog renin. Arch. Biochem.42, 368 (1953).

    Article  PubMed  CAS  Google Scholar 

  • ———: A simple method for the extraction and partial purification of renin. Arch. Biochem.48, 256 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Hamilton, M., J. W. Litchfield, W. S. Peart andG. S. C. Sowry: Phaeochromocytoma. Brit. Heart J.15, No 2, 241 (1953).

    Article  PubMed  CAS  Google Scholar 

  • Haynes, F. W., L. Dexter andR. E. Seibel: Renin content of renal venous blood of normal and hypertensive patients at rest. Amer. J. Physiol.150, 198 (1947).

    PubMed  CAS  Google Scholar 

  • Helmer, O.: A factor in plasma that enhances contraction produced by angiotonin on rabbit aortic strips. Fed. Proc.14, 728 (1955).

    Google Scholar 

  • —: Studies on renin antibodies. Circulation17, 648 (1958).

    PubMed  CAS  Google Scholar 

  • —, andR. M. Sanders: Differentiation between two forms of angiotonin by means of spirally cut strips of rabbit aorta. Amer. J. Physiol.188, 571 (1957).

    PubMed  CAS  Google Scholar 

  • Johnson, C. A., andG. E. Wakerlin: Antiserum for renin. Proc. Soc. exp. Biol. (N.Y.)44, 277 (1940).

    CAS  Google Scholar 

  • Kremen, S. H., andG. E. Wakerlin: Renin and antirenin in treatment of long term experimental renal hypertension in the dog. Proc. Soc. exp. Biol. (N. Y.)90, 99 (1955).

    CAS  Google Scholar 

  • Lamfrom, H., E. Haas andH. Goldblatt: Studies on antirenin. Amer. J. Physiol.177, 55 (1954).

    PubMed  CAS  Google Scholar 

  • Leloir, L. F., J. M. Muñoz, A. C. Taquini, E. Braun-Menéndez y.J. C. Fasciolo La formación del hipertensinogeno. Rev. argent. Cardiol.9, 269 (1942).

    Google Scholar 

  • Lewis, H. A., S. D. Leo andM. Prinzmetal: The effect of re-establishment of circulation in completely ischemic kidneys upon the blood pressure of cats, dogs and rats. Amer. Heart J.21, 319 (1941).

    Article  CAS  Google Scholar 

  • Ludueña, F. P.: Acción de los preparados de hipertensina sobre los músculos lisos. Rev. Soc. argent. Biol.16, 358 (1940).

    Google Scholar 

  • Margolin, E. G., J. P. Merrill andJ. H. Harrison: Diagnosis of hypertension due to occlusions of the renal artery. New Engl. J. Med.256, 581 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Meier, R., F. Gross, J. Tripod u.H. Turrian: Pharmakologische Charakterisierung von synthetischem Hypertensin. Experientia (Basel)13, 361 (1957).

    Article  CAS  Google Scholar 

  • Merrill, A. J., J. L. Morrison andE. S. Brannon: Concentration of renin in renal venous blood in patients with chronic heart failure. Amer. J. Med.1, 468 (1946).

    Article  PubMed  CAS  Google Scholar 

  • Nelson, R. A., L. G. May, A. Bennett, M. Kobayashi andR. Gregory: Comparison of the effects of pressor and depressor agents and influences on pulmonary and systemic pressures of normotensive and hypertensive subjects. Amer. Heart J.50, 172 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Page, I. H., andO. M. Helmer: A crystalline pressor substance (angiotonin) resulting from the reaction between renin and renin-activator. J. exp. Med.71, 29 (1940).

    Article  PubMed  CAS  Google Scholar 

  • Peart, W. S.: The nature of splenic sympathin. J. Physiol. (Lond.)108, 491 (1949).

    Google Scholar 

  • —: Ciba Foundation Symposium on Hypertension. Humoral and neurogenic factors, p. 104. London: Churchill 1954.

    Google Scholar 

  • —: A new method of large-scale preparation of hypertensin, with a note on its assay. Biochem. J.59, 300 (1955) (a).

    PubMed  CAS  Google Scholar 

  • —: The purification of hypertensin. Biochem. J.60, vi (1955) (b).

    PubMed  CAS  Google Scholar 

  • —: The isolation of a hypertensin. Biochem. J.62, 520 (1956).

    PubMed  CAS  Google Scholar 

  • Peart, W. S.: Lecture on “Some biochemical aspects of hypertension” in the Basis of Scientific Medicine.1, 182: Athlone Press 1959.

    Google Scholar 

  • Peart, W. S., andD. Sutton: Renal vein catheterisation and venography: a new technique. Lancet1958, 817.

    Google Scholar 

  • Peterson, E. A., andH. A. Sober: Chromatography of proteins. 1. Cellulose ionexchange adsorbents. J. Amer. chem. Soc.78, 751 (1956).

    Article  CAS  Google Scholar 

  • Picarelli, Z. P., R. Kupper, E. S. Prado andJ. R. Valle: Assay of renin and hypertensin with the isolated guinea-pig ileum. Circulat. Res.2, 354 (1954).

    PubMed  CAS  Google Scholar 

  • Pickering, G. W.: The role of the kidney in acute and chronic hypertension following renal artery constriction in the rabbit. Clin. Sci.5, 229 (1945).

    PubMed  CAS  Google Scholar 

  • —, andM. Prinzmetal: Some observations on renin, a pressor substance contained in normal kidney, together with a method for its biological assay. Clin. Sci.3, 211 (1938).

    CAS  Google Scholar 

  • —— andA. R. Kelsall: The assay of renin in rabbits with experimental renal hypertension. Clin. Sci.4, 401 (1942).

    CAS  Google Scholar 

  • Porath, J.: Methodological studies of zone-electrophoresis in vertical columns. 1. Fractionation in cellulose powder columns of substances of low molecular weight exemplified by amino acids and related compounds. Biochim. biophys. Acta22, 151 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Prinzmetal, M., H. Lewis andS. Leo: Etiology of hypertension due to complete renal ischemia. Proc. Soc. exp. Biol. (N.Y.)43, 696 (1940).

    CAS  Google Scholar 

  • ———: Etiology of hypertension due to complete renal ischemia. J. exp. Med.72, 763 (1940).

    Article  PubMed  CAS  Google Scholar 

  • ——,J. Taggart, H. Williams andD. R. Drury: The effect of transplanted ischemic kidneys and of temporary, complete, renal ischemia upon the blood pressure of rabbits. Amer. Heart J.20, 525 (1940).

    Article  Google Scholar 

  • Quinby, W. C., L. Dexter, J. A. Sandmeyer andF. W. Haynes: The effect of transitory complete constriction of the human renal artery on blood pressure and on the concentration of renin, hypertensinogen and hypertensinase of renal arterial and venous blood, with animal observations. J. clin. Invest.24, 69 (1945).

    Article  PubMed  CAS  Google Scholar 

  • Reid, G., andH. A. Jenkins: The action of renin and hypertensin on the pulmonary and hepatic circulations. Aust. J. exp. Biol. med. Sci.26, 81 (1948).

    Article  PubMed  CAS  Google Scholar 

  • Sapirstein, L. A.: Sodium and water ratios in the pathogenesis od hypertension. Hypertension, Vol. VI, Mineral Metabolism. Proceedings of the Council for High Blood Pressure Research. Amer. Heart Assoc., November 1957, p. 28.

    Google Scholar 

  • Schwarz, H., andI. H. Page: Assay of angiotonin on isolated rat uterus. Fed. Proc.13, 293 (1954).

    Google Scholar 

  • Schwyzer, R., W. Rittel, B. Iselin, H. Kappeler u.B. Riniker: Synthese eines hochwirksamen Hypertensin II-Amids. Helv. chim. Acta40, 614 (1957) (a).

    Article  Google Scholar 

  • —————: Synthese von Hypertensin-II-Peptiden. Angew. Chem.69, 179 (1957) (b).

    Article  Google Scholar 

  • ————— u.H. Zuber: Synthese von Hypertensin peptiden. Über die partielle Hydrolyse von Hypertensin-asp-β-Amiden zu den entsprechenden Dicarbonsäuren. Hypertensin-II-Analoge. Chimia11, 335 (1957) (c).

    CAS  Google Scholar 

  • ——————: Val5-Hypertensin I und II. Chimia12, 91 (1958) (a).

    CAS  Google Scholar 

  • ——————: Synthese hochwirksamer Dekapeptide mit der Aminosäure-Sequenz des val5-Hypertensins I. Helv. chim. Acta41, 1273 (1958) (b).

    Article  CAS  Google Scholar 

  • ——————: Synthese hochwirksamer Oktapeptide mit der vermutlichen Aminosäuresequenz des noch unbekannten Hypertensins II aus Rinderserum (val5-Hypertensin II und val5-Hypertensin II-asp-β-Amid). Helv. chim. Acta41, 1287 (1958) (c).

    Article  CAS  Google Scholar 

  • —, u.P. Sieber: Neuere Synthesen auf dem Peptidgebiet. Chimia10, 265 (1956).

    CAS  Google Scholar 

  • Skeggs, L. T., J. R. Kahn, K. E. Lentz andN. P. Shumway: The preparation, purification and amino-acid sequence of a polypeptide renin substrate. J. exp. Med.106, 439 (1957).

    Article  PubMed  CAS  Google Scholar 

  • —— andN. P. Shumway: The isolation of hypertensin from circulating blood of normal dogs with experimental hypertension by dialysis in the artificial kidney. Circulation3, 384 (1951).

    PubMed  CAS  Google Scholar 

  • ———: The isolation and assay of hypertensin from blood. J. exp. Med.95, 241 (1952).

    Article  PubMed  CAS  Google Scholar 

  • ———: The preparation and function of the hypertensin converting enzyme. J. exp. Med.103, 295 (1956) (a).

    Article  PubMed  CAS  Google Scholar 

  • —,K. E. Lentz, J. R. Kahn andN. P. Shumway: The synthesis of a tetradecapeptide renin substrate. J. exp. Med.108, 283 (1958).

    Article  PubMed  CAS  Google Scholar 

  • ———— andK. R. Woods: Amino-acid sequence of hypertensin II. J. exp. Med.104, 193 (1956) (b).

    Article  PubMed  CAS  Google Scholar 

  • —,W. H. Marsh, J. R. Kahn andN. P. Shumway: The existence of two forms of hypertensin. J. exp. Med.99, 275 (1954) (a).

    Article  PubMed  CAS  Google Scholar 

  • ————: The purification of hypertensin I. J. exp. Med.100, 363 (1954) (b).

    Article  PubMed  CAS  Google Scholar 

  • ————: Amino-acid composition and electrophoretic properties of hypertensin I. J. exp. Med.102, 435 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Smithies, O.: Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. Biochem. J.61, 629 (1955).

    PubMed  CAS  Google Scholar 

  • Sober, H. A., F. J. Gutter, M. M. Wyckoff andE. A. Peterson: Chromatography of proteins. II. Fractionation of serum protein on anion-exchange cellulose. J. Amer. chem. Soc.78, 756 (1956).

    Article  CAS  Google Scholar 

  • Taggart, J., andD. R. Drury: The action of renin on rabbits with renal hypertension. J. exp. Med.71, 857 (1940).

    Article  PubMed  CAS  Google Scholar 

  • Taquini, A. C.: Liberación de substancia hipertensora en el riñon completamente isquemiado. Rev. Soc. argent. Biol.14, 422 (1938).

    CAS  Google Scholar 

  • —: Production de substance hypertensive par le rein ischémié. C.R. Soc. Biol. (Paris)130, 459 (1939).

    CAS  Google Scholar 

  • —: The production of a pressor substance by the totally ischemic kidney. Amer. Heart J.19, 513 (1940).

    Article  Google Scholar 

  • —, yE. Braun-Menéndez: Liberación de la renina por el riñon totalmente isquemiado. Rev. Soc. argent. Biol.17, 465 (1941).

    CAS  Google Scholar 

  • —, andJ. C. Fasciolo: Renin in essential hypertension. Amer. Heart J.32, 357 (1946).

    Article  PubMed  CAS  Google Scholar 

  • Taquini, A. C., J. C. Fasciolo yD. F. Luna: El lugar de formacion de la renina dentro deo rinon. Medicina (B. Aires)10, 174 (1950).

    CAS  Google Scholar 

  • Tigerstedt, R., undP. C. Bergman: Niere und Kreislauf. Skand. Arch. Physiol.8, 223 (1898).

    Google Scholar 

  • Wakerlin, G. E.: Antibodies to renin as proof of the pathogenesis of sustained renal hypertension. Circulation17, 653 (1958).

    PubMed  CAS  Google Scholar 

  • —,R. B. Bird, B. B. Brennon, M. H. Frank, S. Kremen, I. Kuperman andJ. H. Skon: Treatment and prophylaxis of experimental renal hypertension with renin. J. Lab. clin. Med.41, 708 (1953).

    PubMed  CAS  Google Scholar 

  • Yoshimura, F., andK. Shindo: The possible sites of renin formation in the kidneys of the experimental hypertensive rabbits. Endocr. jap.2, 117 (1955).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. St. Mary’s Hospital, London

    W. S. Peart

Authors
  1. W. S. Peart
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1959 Springer-Verlag

About this paper

Cite this paper

Peart, W.S. (1959). Renin and hypertensin. In: Ergebnisse der physiologie biologischen chemie und experimentellen pharmakologie. Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie, vol 50. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0117948

Download citation

  • DOI: https://doi.org/10.1007/BFb0117948

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-02386-9

  • Online ISBN: 978-3-540-36993-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation