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Behavior of liposomes prepared from lung surfactant analogues and spread at the air-water interface

  • A. Colloids Of Biological Interest
  • Conference paper
  • First Online:
Trends in Colloid and Interface Science III

Part of the book series: Progress in Colloid & Polymer Science ((PROGCOLLOID,volume 79))

Abstract

One exogenous surfactant therapy of respiratory distress syndrome (RDS) is to instillate into the lungs enough phospholipid to form a film at the alveolar interface because it has more similar surface properties that the natural surfactant. Liposomal suspensions are able to transport a large amount of phospholipids in situ; therefore, it is interesting to study the transformation of these vesicles into a surface film.

La dipalmitoylphosphatidylcholine — DPPC: La distearoylphosphatidylcholine — DSPC: soybean lecithin — SL (4:4:2) liposomes were spread at the air-physiological solution interface. The spreading kinetics were studied by means of surface pressure, surface potential, and rheological measurements. A theoretical approach to the mechanism of slow transformation of the closed bilayer structures into a surface film has been developed. The properties of surface films formed after spreading of freshly prepared or aged liposomes were compared with those of mixed DPPC:DSPC:SL(4:4:2) monolayers.

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References

  1. Clements JA, Hustead F, Johnson RP, Gribetz I (1961) J Appl Physiol 16:44

    Google Scholar 

  2. Scarpelli EM (1972) The surfactant system of the lung. Lea and Febiger, Philadelphia

    Google Scholar 

  3. Von Neergard KZ (1929) Ges Exp Med 66:373

    Article  Google Scholar 

  4. Avery ME, Mead J (1959) Am J Dis Child 97:517

    CAS  Google Scholar 

  5. Robillard E, Alarie Y, Dagenais-Perusse P, Baril E, Guilbeault A (1964) Can Med Ass J, 90:55

    CAS  Google Scholar 

  6. Chu JS, Clements JA, Cotton EK, Klaus MH, Sweet AY, Tooley WH (1967) Pediatrics 40:709

    Google Scholar 

  7. Obladen M, Brendlein F, Krempien B (1979) Eur J Pediatr 131:219

    Article  CAS  Google Scholar 

  8. Fujiwara T, Tanaka Y, Takei T (1979) IRCS Med Sci 7:311

    CAS  Google Scholar 

  9. Fujiwara T, Maeta H, Chida S, Morita T (1979) IRCS Med Sci 7:313

    Google Scholar 

  10. Fujiwara T, Maeta H, Chida S, Morita T, Watabe Y, Abe T (1980) Lancet 1:55

    Article  CAS  Google Scholar 

  11. Morley CJ, Robertson B, Miller N, Lachmann B, Nilsson R, Bangham A, Grossmann G (1980) Arch Dis Child, 55(10):758

    Article  CAS  Google Scholar 

  12. Morley CJ, Bangham AD, Miller N, Davis JA (1981) Lancet 1:64

    Article  CAS  Google Scholar 

  13. Morley CJ, Bangham AD, Johnson P, Thorburn GD, Jenkin G (1978) Nature 271:162

    Article  CAS  Google Scholar 

  14. Smyth JA, Metcalfe IL, Duffty P, Possmayer F, Bryan MH, Enhorning G (1983) Pediatrics 71(6):913

    CAS  Google Scholar 

  15. Hallman M, Merritt TA, Schneider H, Epstein BL, Mannino F, Edwards DK, Gluck L (1983) Pediatrics 71(4):473

    CAS  Google Scholar 

  16. De Fontanges A, Bonte F, Taupin C, Ober R (1984) J Colloid Interface Sci 101(2):301

    Article  Google Scholar 

  17. Bonte F, Dehan M, De Fontanges A, Lindenbaum A, Perret L, Puisieux F (1985) Arch Fr Peditr 42:397

    CAS  Google Scholar 

  18. Puisieux F (1978) Labo-Pharma 281:899

    Google Scholar 

  19. Delattre J (1979) J Fr Biophys Med Nucl 3(1):3

    Google Scholar 

  20. Puisieux F, Delattre J (1985) Les liposomes, applications thérapeutiques. Ed Technique et Documentation, Lavoisier, Paris

    Google Scholar 

  21. Pattus F, Desnuelle P, Verger R (1978) Biochim Biophys Acta 507:62

    Article  CAS  Google Scholar 

  22. Obladen M, Popp D, Scholl C, Schwartz H, Jahnig F (1983) Biochim Biophys Acta 735:215

    Article  CAS  Google Scholar 

  23. Schindler H (1979) Biochim Biophys Acta 555:316

    Article  CAS  Google Scholar 

  24. Bangham AD, Standish MM, Watkins JC (1965) J Mol Biol 13:238

    CAS  Google Scholar 

  25. Bonte F (1985) Thèse, Paris Sud

    Google Scholar 

  26. De Fotanges A (1985) Thèse, Paris Sud

    Google Scholar 

  27. Takayama M, Itoh S, Nagasaki T, Tanimizu I (1977) Clin Chim Acta 79:93

    Article  CAS  Google Scholar 

  28. Bangham AD, Horne RW (1964) J Mol Biol 8:660

    CAS  Google Scholar 

  29. Dimitrov DS, Panaiotov I (1975–76) Ann Univ Sofia, Fac Chim 70:103

    Google Scholar 

  30. Panaiotov I, Dimitrov DS, Georgiev G (1980) Studia Biophys 78:95

    CAS  Google Scholar 

  31. Dimitrov DS, Panaiotov I, Richmond P, Ter-Minassian-Saraga L (1978) J Colloid Interface Sci 65(3):483

    Article  CAS  Google Scholar 

  32. Panaiotov I, Dimitrov DS, Ter-Minassian-Saraga L (1979) J Colloid Interface Sci 72(1):49

    Article  CAS  Google Scholar 

  33. Panaiotov I (1986) Thesis, Sofia

    Google Scholar 

  34. Carslaw HS, Jaeger JC (1959) Conduction of heat in solids. Oxford Univ Press, Clarendon, Oxford

    Google Scholar 

Download references

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Authors and Affiliations

  1. Pulma Laboratory, Sofia, Bulgaria

    T. Ivanova, G. Georgiev, I. Panaiotov, M. Ivanova, M. A. Launois-Surpas, J. E. Proust & F. Puisieux

  2. Physical Chemistry Department, University of Sofia, Sofia, Bulgaria

    I. Panaiotov & M. Ivanova

  3. Physicochimie des Surfaces et Innovation en Pharmacotechnie CNRS UA 1218, 5 rue J. B. Clément, F-92290, Châtenay-Malabry, France

    M. A. Launois-Surpas, J. E. Proust & F. Puisieux

Authors
  1. T. Ivanova
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  2. G. Georgiev
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  3. I. Panaiotov
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  4. M. Ivanova
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  5. M. A. Launois-Surpas
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  6. J. E. Proust
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  7. F. Puisieux
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Editor information

P. Bothorel E. J. Dufourc

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© 1989 Dr. Dietrich Steinkopff Verlag GmbH & Co. KG

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Ivanova, T. et al. (1989). Behavior of liposomes prepared from lung surfactant analogues and spread at the air-water interface. In: Bothorel, P., Dufourc, E.J. (eds) Trends in Colloid and Interface Science III. Progress in Colloid & Polymer Science, vol 79. Steinkopff. https://doi.org/10.1007/BFb0116181

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  • DOI: https://doi.org/10.1007/BFb0116181

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  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-0831-6

  • Online ISBN: 978-3-7985-1690-8

  • eBook Packages: Springer Book Archive

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