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Colloidal systems for controlled drug delivery — structure activity relationships

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Polymers as Colloid Systems

Part of the book series: Progress in Colloid & Polymer Science ((PROGCOLLOID,volume 72))

Abstract

This study deals with crystalline nonionic surfactant-water mixtures having lamellar gel structures. The release of an extremely hydrophilic drug (nicotinamide) from mixtures with various water contents was measured and the results compared with Differential Scanning Calorimetry data. It is concluded that the lamellar gel structure fits a simple pore model in which the interlamellar channels behave as pores, the porosity being determined by the free (i. e. unbound) water content, the tortuosity by the orientation of the lamellae.

Lecture presented during the 32nd Annual Meeting of the Kolloid-Gesellschaft, Berlin October 2–4, 1985.

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Author information

Authors and Affiliations

  1. Division of Pharmaceutical Technology Gorlaeus Laboratories, Center for Bio-Pharmaceutical Sciences, P.O. Box 9502, 2300, RA Leyden, The Netherlands

    H. E. Boddé, T. De Vringer & H. E. Junginger

Authors
  1. H. E. Boddé
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  2. T. De Vringer
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  3. H. E. Junginger
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J. Springer

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© 1985 Dr. Dietrich Steinkopff Verlag GmbH & Co. KG

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Boddé, H.E., De Vringer, T., Junginger, H.E. (1985). Colloidal systems for controlled drug delivery — structure activity relationships. In: Springer, J. (eds) Polymers as Colloid Systems. Progress in Colloid & Polymer Science, vol 72. Steinkopff. https://doi.org/10.1007/BFb0114476

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  • DOI: https://doi.org/10.1007/BFb0114476

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  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-0728-9

  • Online ISBN: 978-3-7985-1695-3

  • eBook Packages: Springer Book Archive

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