Three dimensional MR-based morphometric comparison of schizophrenic and normal cerebral ventricles

  • David Dean
  • Peter Buckley
  • Fred Bookstein
  • Janardhan Kamath
  • David Kwon
  • Lee Friedman
  • Christine Lys
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 1131)

Abstract

Enlarged cerebral ventricles are consistently detected in patients suffering from schizophrenia. Several workers report more detailed association of this disease and particular brain areas. In order to assist these efforts at localization we define a tiled-out map of the ventricular surface, a template, based on specialized crest lines that we term: ridge curves. In this analysis we use this template to (1) average 3D MR-based ventricular surface images collected from 12 patients and 12 controls, and (2) locate the position of regularly occurring curvature maxima landmarks along the ridge curves. Statistical analysis of the locations of these curvature maxima landmarks indicate promising localization of a shape difference associated with schizophrenia in the frontal horn of the lateral cerebral ventricle.

Keywords

Covariance Schizophrenia Neurol Crest Boulder 

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • David Dean
    • 1
  • Peter Buckley
    • 2
  • Fred Bookstein
    • 4
  • Janardhan Kamath
    • 3
  • David Kwon
    • 2
  • Lee Friedman
    • 2
  • Christine Lys
    • 2
  1. 1.Department of AnatomyCase Western Reserve UniversityCleveland
  2. 2.Department of PsychiatryCase Western Reserve UniversityCleveland
  3. 3.Department of Biomedical EngineeringCase Western Reserve UniversityCleveland
  4. 4.Institute of GerontologyUniversity of MichiganAnn Arbor

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