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Reviews of Physiology, Biochemistry and Pharmacology, Volume 95 pp 149–201Cite as

Physiological and bioenergetic aspects of mitochondrial calcium transport

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Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 95))

Abstract

It is, we hope, apparent from this review that the past five or six years have been a considerable advance in our understanding of the mechanisms and regulation of calcium transport by the isolated mitochondrion. As a result, a field which has tended, for good reason, to be regarded by many physiologists as an artifact of isolated mitochondriology, should now be reexamined as a relevant factor in the complexities of cellular calcium regulation. In particular it would appear to be of prime importance to apply recently developed techniques to resolve the many anomalies concerning the role of mitochondria in specific cellular events.

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Abbreviations

Δψ:

Membrane potential across the inner mitochondrial membrane

ΔμH+ :

Proton electrochemical potential difference across the inner mitochondrial membrane

ΔpH:

pH difference across the inner mitochondrial membrane

Pi :

Phosphate

pCao :

Negative logarithm of the free Ca2+ concentration in the extramitochondrial compartment

ΔμCa :

Calcium electrochemical potential difference across the inner mitochondrial membrane

FCCP:

Carbonyl cyanide p-trifluoromethoxyphenyl hydrazone (proton translocator)

K-Tes:

Potassium 2-([2-hydroxy-1, 1-bis-(hydroxymethyl)-ethyl]amino)-ethanesulphonate

[Cam]:

Free Ca concentration in the mitochondrial matrix

[Cao]:

Free Ca concentration in the incubation medium (experiments with isolated mitochondria)

[Cac]:

Free cytosolic Ca concentration (experiments with intact cells)

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  1. Department of Medical Chemistry, University of Helsinki, Siltavuorenpenger 10, SF 00170, Helsinki, 17, Finland

    Karl E. O. Åkerman

  2. Neurochemistry Laboratory, Department of Psychiatry, University of Dundee, DD1 9SY, Dundee, Scotland, U.K.

    David G. Nicholls

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Åkerman, K.E.O., Nicholls, D.G. (1983). Physiological and bioenergetic aspects of mitochondrial calcium transport. In: Reviews of Physiology, Biochemistry and Pharmacology, Volume 95. Reviews of Physiology, Biochemistry and Pharmacology, vol 95. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0034099

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