Abstract
The characteristics and induction P-450-type monooxygenases are reviewed. A discussion of the location, composition, functional characteristics, and substrate specificities of mammalian liver cytochrome P-450 monooxygenases is provided. This is followed by a description of the effects of inducing agents where particular emphasis is placed on biochemical correlates of induction. After a description of the nature of microbial monooxygenases, induction in these organisms is surveyed. Comparisons are developed for enzymes in fungi, yeasts, and bacteria. Mammalian and microbial hydroxylations of the model hydrocarbon, biphenyl, are reviewed. Results of biphenyl-hydroxylase experiments in mammalian systems are discussed and a rationale described for parallel experiments in microorganisms.
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Smith, R.V., Davis, P.J. (1980). Induction of xenobiotic monooxygenases. In: Advances in Biochemical Engineering, Volume 14. Advances in Biochemical Engineering, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0007189
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