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Mass spectrometry for on-line monitoring of biotechnological processes

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Biotechnology Methods

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 35))

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Abbreviations

a:

surface area [m2]

c:

concentration [mol L−1], [g L−1]

c:

number of measurements

C:

concentration matrix

CUR:

carbon dioxide uptake rate [mol s−1]

CTR:

carbon dioxide transfer rate [mol s−1]

d:

deviation [s m−1]

D:

diffusion coefficients [m2 s−1]

DO:

dissolved oxygen concentration [g L−1]

F:

flow rate [mol s−1]

H:

Henry coefficient [mol m−3 Pa−1]

I:

ion current [A]

I:

matrix of ion currents

K:

equilibrium constant [mol L−1]

k:

MS calibration constant [mol m3 A−1]

k1a:

volumetric mass transfer coefficient [s−1]

l:

membrane thickness [m]

M:

molecular weight [g mol−1]

n:

number of components

OD:

optical density

OUR:

oxygen uptake rate [mol s−1]

OTR:

oxygen transfer rate [mol s−1]

p:

pressure [Pa]

r:

reaction rate [mol L−1 s−1]

r:

number of masses

R:

gas constant [Pa m3 K]

R:

film resistance [s m−1]

RQ:

respiratory quotient

s:

sensitivity coefficient [A l g−1]

S:

matrix of sensitivity coefficients

t:

time [s], [h]

T:

temperature [K], [‡C]

V:

volume [m3]

x:

mole fraction

X:

biomass concentration [g m−3]

Τ:

residence time, response time [s]

b:

refers to boundary layer

g:

refers to gas phase

in:

refers to reactor inlet

l:

refers to liquid phase

m:

refers to membrane

out:

refers to reactor outlet

tot:

total

*:

refers to equilibrium value

′:

relative

DC:

direct current

FAB:

fast atom bombardment ionization

FD:

field desorption ionization

FE:

field emission ionization

FT:

Fourier transform

EI:

electron impact ionization

GC:

gas chromatography

HPLC:

high performance liquid chromatography

i.d.:

inner diameter

MS:

mass spectrometer (-metry)

m/z:

mass to charge ratio

SEM:

secondary electron multiplier

SIM:

selected ion monitoring

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  1. E. Heinzle

    Present address: Chemical Engineering Laboratory, ETH-Zentrum, CH-8092, Zürich, Switzerland

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  1. Institute for Environmental Research, Elisabethstr. 11, A-8010, Graz, Austria

    E. Heinzle

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© 1987 Springer-Verlag

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Heinzle, E. (1987). Mass spectrometry for on-line monitoring of biotechnological processes. In: Biotechnology Methods. Advances in Biochemical Engineering/Biotechnology, vol 35. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0004425

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  • DOI: https://doi.org/10.1007/BFb0004425

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  • Print ISBN: 978-3-540-17627-5

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