Abstract
Natural products have emerged as promising candidates for the development of nano-antidiabetic drugs, presenting a novel approach to combat the rising global burden of diabetes. These bioactive compounds with intricate chemical entities and multifaceted pharmacological effects are mainly of plant origin. In the context of diabetes, natural products exhibit a wide range of modes of action that include modulation of insulin secretion, expediting insulin signalling cascades, improving insulin sensitivity, regulating enzymes involved in glucose metabolism, and attenuating oxidative stress and inflammations. These intricate mechanisms of actions, combined with the potential synergistic interactions among the phytocompounds, contribute to their profound anti-diabetic effects. Despite the promising pharmacokinetic properties exhibited by the phytoconstituents, poor solubility and bioavailability are the main challenges faced by this system of treating diabetes. The utilization of nanotechnology in formulating natural products as nano-antidiabetic drugs offers numerous advantages over conventional approaches. Nanoencapsulation techniques enable precise control over the physicochemical properties of drug, such as solubility, stability, and bioavailability, thereby enhancing their therapeutic efficacy. Furthermore, nanoscale drug delivery systems facilitate targeted delivery and sustained release of active compounds, optimizing their pharmacokinetics and minimizing potential side effects. Beyond their therapeutic benefits, nano-antidiabetic drugs offer sustainable and environmentally friendly approaches to diabetes management.
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Archana, T.M., Sudheesh, S. (2024). Natural Products as Nano-Antidiabetic Drugs. In: Haridas, M., Abdulhameed, S., Francis, D., Kumar, S.S. (eds) Drugs from Nature: Targets, Assay Systems and Leads. Springer, Singapore. https://doi.org/10.1007/978-981-99-9183-9_19
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