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Large Hemispheric Stroke

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Case-based Approach to Common Neurological Disorders
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Abstract

A 72-year-old female was brought to the emergency with a history of right-sided weakness and inability to speak which was discovered at 5 pm when her family members returned from work. She was well when she had breakfast with them at 7 am. The family said that she had not cooked the morning meal that day. She did not have a significant medical history except that she was on losartan 50 mg once daily for hypertension. On examination, her vital signs were stable. She had global aphasia, right homonymous hemianopia, forced eye deviation to the left side, right upper motor neuron-type facial nerve palsy, and complete plegia of the right upper and lower limbs. Her National Institutes of Health Stroke Scale (NIHSS) score was 22. Her computed tomography (CT) scan done at presentation did not show any abnormality (Fig. 14.1). Due to the lack of facility for mechanical intervention, she was managed conservatively. However, on day 2, her level of consciousness deteriorated. Her repeat CT scan of the head then showed a large hemispheric infarct with significant mass effect (Fig. 14.2). The next day, her level of consciousness further deteriorated and she had to be intubated to maintain airway and prevent aspiration. Further, CT scan of the head was repeated which showed massive midline shift (Fig. 14.3). She underwent decompressive hemicraniectomy the same day, and subsequently improved to a modified Rankin Score (mRS) of 5 after a long stay in the intensive unit care (Fig. 14.4).

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References

  1. Wijdicks EFM, Sheth KN, Carter BS, Greer DM, Kasner SE, Kimberly WT, Schwab S, Smith EE, Tamargo RJ, Wintermark M, on behalf of the American Heart Association Stroke Council. Recommendations for the management of cerebral and cerebellar infarction with swelling: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45:1222–38.

    Article  PubMed  Google Scholar 

  2. Hao Z, Chang X, Zhou H, Lin S, Liu M. A cohort study of decompressive craniectomy for malignant middle cerebral artery infarction: a real-world experience in clinical practice. Medicine (Baltimore). 2015;94:e1039.

    Article  PubMed  Google Scholar 

  3. Hartmann F, Juettler E, Singer OC, Lehnhardt FG, Köhrmann M, Kersten JF, Sobesky J, Gerloff C, Villringer A, Fiehler J, Neumann-Haefelin T, Schellinger PD, Röther J, Thomalla G, Clinical Trial Net of the German Competence Network Stroke. Prediction of malignant middle cerebral artery infarction by magnetic resonance imaging within 6 hours of symptom onset: a prospective multicenter observational study. Ann Neurol. 2010;68:435–45.

    Article  PubMed  Google Scholar 

  4. Liebeskind DS, Jüttler E, Shapovalov Y, Yegin A, Landen J, Jauch EC. Cerebral edema associated with large hemispheric infarction. Stroke. 2019;50(9):2619–25.

    Article  PubMed  Google Scholar 

  5. Kahle KT, Simard JM, Staley KJ, Nahed BV, Jones PS, Sun D. Molecular mechanisms of ischemic cerebral edema: role of electroneutral ion transport. Physiology (Bethesda). 2009;24:257–65.

    CAS  PubMed  Google Scholar 

  6. Dostovic Z, Dostovic E, Smajlovic D, Ibrahimagic OC, Avdic L. Brain edema after ischaemic stroke. Med Arch. 2016;70:339–41.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Kimberly WT, Sheth KN. Approach to severe hemispheric stroke. Neurology. 2011;76(7 Suppl 2):S50–6.

    PubMed  Google Scholar 

  8. Moulin T, Cattin F, Crépin-Leblond T, Tatu L, Chavot D, Piotin M, Viel JF, Rumbach L, Bonneville JF. Early CT signs in acute middle cerebral artery infarction: predictive value for subsequent infarct locations and outcome. Neurology. 1996;47:366–75.

    Article  CAS  PubMed  Google Scholar 

  9. Oppenheim C, Samson Y, Manaï R, Lalam T, Vandamme X, Crozier S, Srour A, Cornu P, Dormont D, Rancurel G, Marsault C. Prediction of malignant middle cerebral artery infarction by diffusion weighted imaging. Stroke. 2000;31(9):2175–81.

    Article  CAS  PubMed  Google Scholar 

  10. Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, Biller J, Brown M, Demaerschalk BM, Hoh B, Jauch EC, Kidwell CS, Leslie-Mazwi TM, Ovbiagele B, Scott PA, Sheth KN, Southerland AM, Summers DV, Tirschwell DL, on behalf of the American Heart Association Stroke Council. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2018;2018(49):e46–99.

    Google Scholar 

  11. Torbey MT, Bösel J, Rhoney DH, Rincon F, Staykov D, Amar AP, Varelas PN, Jüttler E, Olson D, Huttner HB, Zweckberger K, Sheth KN, Dohmen C, Brambrink AM, Mayer SA, Zaidat OO, Hacke W, Schwab S. Evidence-based guidelines for the management of large hemispheric infarction: a statement for health care professionals from the Neurocritical Care Society and the German Society for Neuro-intensive Care and Emergency Medicine. Neurocrit Care. 2015;22(1):146–64.

    Article  PubMed  Google Scholar 

  12. Back L, Nagaraja V, Kapur A, Eslick GD. Role of decompressive hemicraniectomy in extensive middle cerebral artery strokes: a meta-analysis of randomised trials. Intern Med J. 2015;45(7):711–7.

    Article  CAS  PubMed  Google Scholar 

  13. Vahedi K, Hofmeijer J, Juettler E, Vicaut E, George B, Algra A, Amelink GJ, Schmiedeck P, Schwab S, Rothwell PM, Bousser MG, van der Worp HB, Hacke W, DECIMAL, DESTINY, and HAMLET investigators. Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials. Lancet Neurol. 2007;6(3):215–22.

    Article  PubMed  Google Scholar 

  14. Jaramillo A, Góngora-Rivera F, Labreuche J, Hauw JJ, Amarenco P. Predictors for malignant middle cerebral artery infarctions: a postmortem analysis. Neurology. 2006;66:815–20.

    Article  CAS  PubMed  Google Scholar 

  15. Cucchiara BL, Kasner SE, Wolk DA, Lyden PD, Knappertz VA, Ashwood T, Odergren T, Nordlund A, CLASS-I Investigators. Early impairment in consciousness predicts mortality after hemispheric ischemic stroke. Crit Care Med. 2004;32(1):241–5.

    Article  PubMed  Google Scholar 

  16. Elijovich L, Goyal N, Mainali S, Hoit D, Arthur AS, Whitehead M, Choudhri AF. CTA collateral score predicts infarct volume and clinical outcome after endovascular therapy for acute ischemic stroke: a retrospective chart review. J Neurointervent Surg. 2016;8:559–62.

    Article  Google Scholar 

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Correspondence to Bikram Prasad Gajurel .

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Gajurel, B.P. (2024). Large Hemispheric Stroke. In: Oli, K.K., Shrestha, G.S., Ojha, R., Pal, P.K., Pandey, S., Das, B. (eds) Case-based Approach to Common Neurological Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-99-8676-7_14

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  • DOI: https://doi.org/10.1007/978-981-99-8676-7_14

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