Skip to main content

Multidrug-Resistant Tuberculosis

  • Chapter
  • First Online:
Diagnostic Imaging of Drug Resistant Pulmonary Tuberculosis

Abstract

Multidrug-resistant tuberculosis (MDR-TB) is defined as a tuberculosis induced by Mycobacterium tuberculosis resistant at least simultaneously to isoniazid and rifampin, as confirmed by drug susceptibility testing (DST) in vitro [1]. Based on the presence/absence of previous exposure to anti-tuberculosis treatment, MDR-TB can be categorized into the new multidrug-resistant tuberculosis (nMDR-TB) and the relapsing multidrug-resistant tuberculosis (rMDR-TB) [2]. The nMDR-TB are the MDR-TB patients who have not received anti-TB therapy or have taken anti-TB drugs for less than 1 month, and the latter defined as MDR-TB occurring in patients with such a previous exposure or in those undergoing anti-tuberculosis treatment lasting more than 1 month.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. WHO. Global Tuberculosis Report 2020 [DB/OL]. https://www.who.int/teams/global-tuberculosis-programme/tb-reports.

  2. Yu W, Tan W-g, Lu P-x. Classification and imaging manifestations of drug-resistant pulmonary tuberculosis [J/CD]. Electr J Emerg Infect Dis. 2019;4(1):42–7.

    Google Scholar 

  3. World Health Organization. Global tuberculosis report 2021 [EB/OL]. [2021-10-14]. https://www.who.int/publications/digital/global-tuberculosis-report-2021.

  4. Li C, Lu S, Wang H, et al. CT scan findings of multi-drug resistant pulmonary tuberculosis patients and its correlation to CD4 cells [J]. Chin J Antituberc. 2017;39(6):597–603.

    Google Scholar 

  5. Chuchottaworn C, Thanachartwet V, Sangsayunh P, et al. Risk factors for multidrug-resistant tuberculosis among patients with pulmonary tuberculosis at the central chest Institute of Thailand [J]. PLoS One. 2015;10(10):e0139986.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Wang Y-x, Chung MJ, Skrahin A, et al. Literature analysis of radiological signs related to multidrug-resistant tuberculosis [J/CD]. Electr J Emerg Infect Dis. 2018;3(2):244–53.

    Google Scholar 

  7. Yang J, Lu S, Tang G, et al. An analysis of CT scan findings of treatment-naive and relapsing multidrug resistant pulmonary tuberculosis [J]. Chin J Antituberc. 2020;42(1):38–43.

    Google Scholar 

  8. Ong CW, Elkington PT, Friedland JS. Tuberculosis, pulmonary cavitation, and matrix metalloproteinases [J]. Am J Respir Crit Care Med. 2014;190(1):9–18.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Li C, Zhou X, Lu Y, et al. An analysis of CT scan findings of pulmonary tuberculosis differing in the category of drug-resistance and drug-susceptible pulmonary tuberculosis [J]. Chin J Antituberc. 2018;40(7):707–12.

    Google Scholar 

  10. Wáng YXJ, Chung MJ, Skrahin A, et al. Radiological signs associated with pulmonary multi-drug resistant tuberculosis: an analysis of published evidences [J]. Quant Imaging Med Surg. 2018;8(2):161–73.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Belton M, Brilha S, Manavaki R, et al. Hypoxia and tissue destruction in pulmonary TB [J]. Thorax. 2016;71(12):1145–53.

    Article  PubMed  Google Scholar 

  12. Volkman HE, Pozos TC, Zheng J, et al. Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium [J]. Science. 2010;327(5964):466–9.

    Article  CAS  PubMed  Google Scholar 

  13. Elkington P, Shiomi T, Breen R, et al. MMP-1 drives immunopathology in human tuberculosis and transgenic mice [J]. J Clin Invest. 2011;121(5):1827–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 People's Medical Publishing House, PR of China

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Li, Ch. et al. (2023). Multidrug-Resistant Tuberculosis. In: Lu, PX., Lu, Hz., Yi, Yx. (eds) Diagnostic Imaging of Drug Resistant Pulmonary Tuberculosis. Springer, Singapore. https://doi.org/10.1007/978-981-99-8339-1_6

Download citation

  • DOI: https://doi.org/10.1007/978-981-99-8339-1_6

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-99-8338-4

  • Online ISBN: 978-981-99-8339-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics