Abstract
This paper proposes a cascade control approach with a 2DOF-PID controller for finding the optimal drug schedule during chemotherapeutic treatment. The cell-cycle nonspecific model of tumor growth for breast cancer is considered. Drug concentration and toxicity are regulated by individual controllers. The main objective of the controller design is to reduce the tumor size with minimum harm to the patient. The problem of diverse objectives in chemotherapy is solved by using the NSGA-II optimization technique. The response by 2DOF-PID and conventional PID approach are compared for the designed model. In addition, the performance of controllers in dealing with parametric uncertainty is also included in this work. The findings suggest that the proposed 2DOF-PID technique performs better.
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References
Martin RB (1992) Optimal control drug scheduling of cancer chemotherapy. Automatica 28(6):1113–1123
Gardner SN (2002) Cell cycle phase-specific chemotherapy: Computation methods for guiding treatment. Cell Cycle 1(6):369–374
Shi J, Alagoz O, Erenay FS, Su Q (2014) A survey of optimization models on cancer chemotherapy treatment planning. Annal Operat Res 221(1):331–356
Panjwani B, Singh V, Rani A et al (2021) Optimum multi-drug regime for compartment model of tumour: cell-cycle-specific dynamics in the presence of resistance. J Pharmacokinet Pharmacodyn 48:543–562
Sofiane K et al (2016) A measurement-based control design approach for efficient cancer chemotherapy. Inf Sci 333:108–125
Tse S-M, Liang Y, Leung K-S, Lee K-H, Mok TS-K (2007) A memetic algorithm for multiple-drug cancer chemotherapy schedule optimization. IEEE Trans Syst Man Cybern Part B Cybernetics 37(1):84–91
Panjwani B, Mohan V, Rani A, Singh V (2019) Optimal drug scheduling for cancer chemotherapy using two degree of freedom fractional order PID scheme. J Intell Fuzzy Syst 36(3):2273–2284
Mohan V, Chhabra H, Rani A, Singh V (2019) An expert 2DOF fractional order fuzzy PID controller for nonlinear systems. Neural Comput Appl 31(8):4253–4270
Deb K et al (2002) A fast and elitist multiobjective genetic algorithm: NSGA-II. IEEE Trans Evolut Comput 6.2:182–197
Mohan V, Chhabra H, Rani A, Singh V (2018) Robust self-tuning fractional order PID controller dedicated to non-linear dynamic system. J Intell Fuzzy Syst 34(3):1467–1478
Pachauri N, Panjwani B, Vigneysh T, Mohan V (2023) A cascaded NPID/PI scheme for the regulation of stack voltage in proton exchange membrane fuel cell. Int J Hydrogen Energy. ISSN 0360–3199
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Panjwani, B., Mohan, V., Gupta, H., Verma, O.P. (2024). A Cascaded 2DOF-PID Control Technique for Drug Scheduling of Chemotherapy System. In: Verma, O.P., Wang, L., Kumar, R., Yadav, A. (eds) Machine Intelligence for Research and Innovations. MAiTRI 2023. Lecture Notes in Networks and Systems, vol 832. Springer, Singapore. https://doi.org/10.1007/978-981-99-8129-8_7
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DOI: https://doi.org/10.1007/978-981-99-8129-8_7
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Online ISBN: 978-981-99-8129-8
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