Abstract
Vitamin and mineral deficiencies is a significant risk factor in the global burden of disease. Widely practiced strategies to address these deficiencies are supplementation and food fortification. The focus of this article is on global and national evidence base for the success of pharmaceutical supplementation and food fortification as strategies in preventing and controlling micronutrient deficiencies. Both these strategies have been found to impact in preventing and controlling dietary deficiencies of micronutrients. Food fortification demands country specific regulation based on standards and extent of spread of deficit in specific micronutrients, evidence base for impact, demand and availability, introduction of mandatory or voluntary and needs careful contextual consideration. Continuous monitoring using biomarkers and taking contextual corrective steps such as redesigning and withdrawing low impact interventions should form integral part of the policy system. The present evidences on certain micronutrients appear to be inadequate to formulate guidelines either for or against the use of single or multi vitamins and minerals supplements to prevent chronic diseases. Consideration for other public health strategies such as point of use fortification with multiple micronutrient powder (MNP) sachet for children and multiple micronutrient supplement (MMS) for pregnant women merits consideration for large scale trials. An attempt has been made to understand the challenges, knowledge gaps and research priorities in the area.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Athe R, Rao MV, Nair KM (2014) Impact of iron-fortified foods on Hb concentration in children (<10 years): a systematic review and meta-analysis of randomized controlled trials. Public Health Nutr 17:579–586
Bhutta ZA, Ahmed T, Black RE, Cousens S, Dewey K, Giugliani E, Haider BA, Kirkwood B, Morris SS, Sachdev HPS (2008) What works? Interventions for maternal and child undernutrition and survival. Lancet 371(9610):417–440
Black MM, Fernandez-Rao, Nair KM, Balakrishna N et al (2021) A randomized multiple micronutrient powder point-of-use fortification trial implemented in Indian preschools increases expressive language and reduces anaemia and iron deficiency. J Nutr 151(7):2029–2042. https://doi.org/10.1093/jn/nxab066
Brown B, Wright C (2020) Safety and efficacy of supplements in pregnancy. Nutr Rev 78(10):813–826. https://doi.org/10.1093/nutrit/nuz101
Codex (2005) CAC/GL 55 - 2005 Codex. www.fao.org/input/download/standards/10206/cxg_055e.pdf
Das JK, Salam RA, Kumar R, Bhutta ZA (2013) Micronutrient fortification of food and its impact on woman and child health: a systematic review. Syst Rev 23(2):67. https://doi.org/10.1186/2046-4053-2-67
De-Regil AM, Thankachan P, Muthayya S, Goud RB, Kurpad AV, Hurrell RF, Zimmermann MB (2008) Dual fortification of salt with iodine and iron: a randomized, double-blind, controlled trial of micronized ferric pyrophosphate and encapsulated ferrous fumarate in southern India. Am J Clin Nutr 88:1378–1387
De-Regil LM, Jefferds MED, Peña-Rosas JP (2017) Point-of-use fortification of foods with micronutrient powders containing iron in children of preschool and school-age. Cochrane Database Syst Rev 2023(11):CD009666. https://doi.org/10.1002/14651858.CD009666.pub2. Accessed 13 July 2023
El-Kadiki A, Sutton AJ (2005) Role of multivitamins and mineral supplements in preventing infections in elderly people: systematic review and meta-analysis of randomised controlled trials. BMJ 330:871
Fairfield K, Stamfer M (2007) Vitamin and mineral supplement for cancer prevention, issues and evidence. Am J Clin Nutr 85(1):289S–292S
FAO (1995) FAO technical consultation on food fortification: technology and quality control. FAO, Rome, pp 20–23. http://www.fao.org/docrep/W2840E/w2840e0b.htm#1
FAO (1997) Preventing micronutrient malnutrition: a guide to food-based approaches - a manual for policy makers and programme planners. International Life Sciences Institute, Washington
FSSAI (2018). https://www.fssai.gov.in/upload/uploadfiles/files/Gazette_Notification_Food_Fortification_10_08_2018.pdf
FSSAI (2022). https://www.fssai.gov.in/upload/uploadfiles/files/Gazette_Notification/Nutra_30_03_2022.pdf
Gera T, Sachdev HS, Erick B (2012) Effect of iron fortified foods on hematological and biological outcomes: systematic reviews of randomized controlled trials. Am J Clin Nutr 96:309–324
Ghosh S, Thomas T, Pullakhandam R, Nair KM, Sachdev HS, Kurpad AV (2023) A proposed method for defining the required fortification level of micronutrients in foods: an example using iron. Eur J Clin Nutr 77(4):436–446. https://doi.org/10.1038/s41430-022-01204-4
Gomes F, Agustina R, Black RE, Christian P, Dewey KG, Kraemer K, Shankar AH, Smith ER, Thorne-Lyman A, Tumilowicz A, Bourassa MW (2022a) Multiple micronutrient supplements versus iron-folic acid supplements and maternal anaemia outcomes: an iron dose analysis. Ann N Y Acad Sci 1512(1):114–125. https://doi.org/10.1111/nyas.14756
Gomes F, Black RE, Smith E, Shankar AH, Christian P (2022b) Micronutrient supplements in pregnancy: an urgent priority. Lancet Glob Health 10(9):e1239. https://doi.org/10.1016/S2214-109X(22)00308-4
Greenwald P, Anderson D, Nelson SA, Taylor PR (2007) Clinical trials of vitamin and mineral supplements for cancer prevention. Am J Clin Nutr 85(1):313–317
Haas JD, Rahn M, Venkatramanan S, Marquis GS, Wenger MJ, Murray-Kolb LE, Wesley AS, Reinhart GA (2014) Double-fortified salt is efficacious in improving indicators of iron deficiency in female Indian tea pickers. J Nutr 144:957–964
Haider BA, Bhutta ZA (2015) Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev 2015:Cd004905
Heaney RP (2007) Bone health. Am J Clin Nutr 85(1):300S–303S
ICMR-NIN (2010) Indian Council of Medical Research. Nutrient requirements and recommended dietary allowances for Indians. In: A report of the expert group of the Indian Council of Medical Research. National Institute of Nutrition, Hyderabad
ICMR-NIN (2020) Indian Council of Medical Research/National Institute of Nutrition. Nutrient Requirements for Indians. Department of Health Research, Ministry of Health and Family Welfare, Government of India
Imdad A, Mayo-Wilson E, Haykal MR, Regan A, Sidhu J, Smith A, Bhutta ZA (2022) Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age. Cochrane Database Syst Rev 3(3):CD008524. https://doi.org/10.1002/14651858.CD008524.pub4
Kapil U, Sachdev HPS (2013) Massive dose vitamin A programme in India - need for a targeted approach. Indian J Med Res 138(3):411–417
Khadgawat R, Marwaha RK, Garg MK, Ramot R, Oberoi AK, Sreenivas V, Gahlot M, Mehan N, Mathur P, Gupta N (2013) Impact of vitamin D fortified milk supplementation on vitamin D status of healthy school children aged 10-14 years. Osteoporos Int 24(8):2335–2343. https://doi.org/10.1007/s00198-013-2306-9
Konapur A, Gavaravarapu SM, Nair KM (2022) The 5 A’s approach for contextual assessment of food environment. J Nutr Educ Behav 54(7):621–635. https://doi.org/10.1016/j.jneb.2022.02.017
Kurpad AV, Sachdev HS (2022) Precision in prescription: multiple micronutrient supplements in pregnancy. Lancet Glob Health 10(6):e780–e781. https://doi.org/10.1016/S2214-109X(22)00207-8
Kurpad AV, Ghosh S, Thomas T, Bandyopadhyay S et al (2021) Perspective: when the cure might become the malady: the layering of multiple interventions with mandatory micronutrient fortification of foods in India. Am J Clin Nutr 2021:1–6. https://doi.org/10.1093/ajcn/nqab245
Laxmaiah A, Nair KM, Arlappa N, Raghu P, Balakrishna N, Rao KM, Galreddy C, Kumar S, Ravindranath M, Rao VV, Brahmam GN (2012) Prevalence of ocular signs and subclinical vitamin A deficiency and its determinants among rural pre-school children in India. Public Health Nutr 15(4):568–577. https://doi.org/10.1017/S136898001100214X
Marks KJ, Luthringer CL, Ruth LJ, Rowe LA, Khan NA, De-Regil LM, López X, Pachón H (2018) Review of grain fortification legislation, standards, and monitoring documents. Glob Health Sci Pract 6(2):356–371. https://doi.org/10.9745/GHSP-D-17-00427
MoHFW (2019) Comprehensive National Nutrition Survey (CNNS). National report 2016–2018. MoHFW, Government of India, UNICEF and Population Council, New Delhi
Moretti D, Zimmermann MB, Muthayya S, Thankachan P, Lee TC, Kurpad AV, Hurrell RF (2006) Extruded rice fortified with micronized ground ferric pyrophosphate reduces iron deficiency in Indian school children: a double-blind randomized controlled trial. Am J Clin Nutr 84:822–829
Mozaffarian D, Blanck HM, Garfield KM, Wassung A, Petersen R (2022) A food is medicine approach to achieve nutrition security and improve health. Nat Med 28:2238–2240
Muthayya S, Thankachan P, Hirve S, Amalrajan V, Thomas T, Lubree H, Agarwal D, Srinivasan K, Hurrell RF, Yajnik CS, Kurpad AV (2012) Iron fortification of whole wheat flour reduces iron deficiency and iron deficiency anaemia and increases body iron stores in Indian school-aged children. J Nutr 142(11):1997–2003. https://doi.org/10.3945/jn.111.155135
NAAS (2022) Food fortification: issues and way forward, Policy Paper No. 111. National Academy of Agricultural Sciences, New Delhi, p 20
Nair KM (2019) Contextualizing the principles of iron fortification of foods in India, NFI Bulletin April
Nair KM (2022) Addressing iron bioavailability: core strategy to achieve aneaemia mukt Bharat. Bull Nutr Found India 43:4
Nair KM, Augustine LF (2016) Basis for current allowances of nutrients for food fortification in India. Nutr Bull 37(3):1–5
Nair KM, Iyengar V (2009) Iron content, bioavailability & factors affecting iron status of Indians. Indian J Med Res 130:634–645
Nair KM, Brahmam GNV, Ranganathan S, Vijayaraghavan K, Sivakumar B, Krishnaswamy K (1998) Impact evaluation of iron and iodine fortified salt. Indian J Med Res 108:203–211
Nair KM, Bhaskaram P, Balakrishna N, Ravinder P, Sesikeran B (2004) Response of haemoglobin, serum ferritin and serum transferrin receptor during iron supplementation in pregnancy: a prospective study. Nutrition 20:896
Nair KM, Brahmam GN, Radhika MS, Dripta RC, Ravinder P, Balakrishna N, Chen Z, Hawthorne KM, Abrams SA (2013) Inclusion of guava enhances non-heme iron bioavailability but not fractional zinc absorption from a rice-based meal in adolescents. J Nutr 143(6):852–858. https://doi.org/10.3945/jn.112.171702
Nair KM, Fernandez-Rao S, Nagalla B, Kankipati RV, Punjal R, Augustine LF, Hurley KM, Tilton N, Harding KB, Reinhart G, Black MM (2016) Characterisation of anaemia and associated factors among infants and pre-schoolers from rural India. Public Health Nutr 19(5):861–871. https://doi.org/10.1017/S1368980015002050
Nair KM, Choudhury DR, Konapur A (2018) Appropriate doses of iron for treatment of anaemia amongst pregnant and lactating mothers; under 5 children. Children 6-10 years of age; adolescent girls and women of reproductive age groups. Indian J Community Health 30(Suppl):39–53
NFHS-3 (2006) International Institute for Population Sciences (IIPS) and ICF. 2006. National Family Health Survey (NFHS-3), 2005-06: India. IIPS, Mumbai
NFHS-4 (2016) International Institute for Population Sciences (IIPS) and ICF. National Family Health Survey (NFHS-4), 2015-16: India. IIPS, Mumbai
NFHS-5 (2021) International Institute for Population Sciences (IIPS) and ICF. National Family Health Survey (NFHS-5), 2019-21: India. IIPS, Mumbai
NHP (2017) Ministry of Health and Family Welfare, Government of India
NNMB (2012) Diet and nutritional status of rural population and prevalence of hypertension. Third repeat survey. NNMB Technical report series 26. National Institute of Nutrition (ICMR), Hyderabad
NNMB (2016) Report for the year 2016. Technical Report Series. National Nutrition Monitoring Bureau, National Institute of Nutrition (ICMR), Hyderabad
Pachón H, Spohrer R, Mei Z, Serdula MK (2015) Evidence of the effectiveness of flour fortification programs on iron status and anaemia: a systematic reviews. Nutr Rev 73:780–795. https://doi.org/10.1093/nutrit/nuv037
Pandav CS, Yadav K, Srivastava R, Pandav R, Karmarkar MG (2013) Iodine deficiency disorders (IDD) control in India. Indian J Med Res 138:418–433
Pfeiffer CM, Caudill SP, Gunter EW, Osterloh J, Sampson EJ (2005) Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999-2000. Am J Clin Nutr 82(2):442–450. https://doi.org/10.1093/ajcn.82.2.442
Prentice RL (2007) Clinical trials and observational studies to assess the chronic disease benefits and risks of multivitamin-mineral supplements. Am J Clin Nutr 85(1):308S–313S
Radhika MS, Nair KM, Hari Kumar R, Rao VM, Ravinder P, Gal Reddy C, Brahmam GNV (2011) Micronized ferric pyrophosphate supplied through extruded rice kernels improves body iron stores in children: doubleblind, randomized placebo-controlled midday meal feeding trial in Indian school children. Am J Clin Nutr 94:1202–1210
Ranganathan S, Reddy V, Ramamoorthy P (1996) Large scale production of salt fortified with iodine and iron. Food Nutr Bull 17:73–78
Ranjith A, Puri S, Vohra K, Khanam A, Bairwa M, Kaur R, Yadav K (2022) Ideal dose of iron in multiple micronutrient supplement: a narrative review of evidence. Cureus 14(9):e28688. https://doi.org/10.7759/cureus.28688. PMID: 36199654; PMCID: PMC9526876
Rao BSN (1994) Fortification of salt with iron and iodine to control anaemia and goitre. Development of a new formula with good stability and bioavailability of iron and iodine. Food Nutr Bull 15:32–39
Roy Choudhury D, Nair KM, Nagalla B, Vijaya Kankipati R, Ghosh S, Buwade J, Fernandez-Rao S (2021) Guava with an institutional supplementary meal improves iron status of preschoolers: a cluster-randomized controlled trial. Ann N Y Acad Sci 1492(1):82–95. https://doi.org/10.1111/nyas.14556
Roy M, Pitkin A (2007) Folate and neural tube defects. Am J Clin Nutr 85(1):285S–288S. https://doi.org/10.1093/ajcn/85.1.285S
Sarna A, Porwal A, Ramesh S, Agrawal PK, Acharya R, Johnston R, Khan N, Sachdev HPS, Nair KM, Ramakrishnan L, Abraham R, Deb S, Khera A, Saxena R (2020) Characterisation of the types of anaemia prevalent among children and adolescents aged 1–19 years in India: a population-based study. Lancet Child Adolesc Health 4(7):515–525
Sivakumar B, Nair KM (2002) Double fortified salt at crossroads. Indian J Pediatr 69:617–623
Stevens GA, Finucane MM, De-Regil LM, Paciorek CJ, Flaxman SR, Branca F, Peña-Rosas JP, Bhutta ZA, Ezzati M, Nutrition Impact Model Study Group (Anaemia) (2013) Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995-2011: a systematic analysis of population-representative data. Lancet Glob Health 1(1):16–25. https://doi.org/10.1016/S2214-109X(13)70001-9
Swaminathan MC, Susheela TP, Thimmayamma VS (1970) Field prophylactic trial with a single annual oral massive dose of vitamin A. Am J Clin Nutr 23:119–122
Traber MG (2007) Heart disease and single-vitamin supplementation. Am J Clin Nutr 85(1):293S–299S
Tuncalp Ö, Rogers LM, Lawrie TA, Barreix M, Peña-Rosas JP, Bucagu M, Neilson J, Oladapo OT (2020) WHO recommendations on antenatal nutrition: an update on multiple micronutrient supplements. BMJ Glob Health 5(7):e003375. https://doi.org/10.1136/bmjgh-2020-003375
UNICEF/WHO/UNU (1999) Composition of a multi-micronutrient supplement to be used in pilot programmes among pregnant women in developing countries. In: Report of an UNICEF/WHO/UNU workshop. UNICEF, New York. http://www.idpas.org/pdf/059CompositionofMult-MicronutrientSupplement.pdf
West KP and Sommer A (1987). Delivery of oral doses of vitamin A to prevent vitamin A deficiency and nutritional blindness. A state-of-the-art review. Nutrition Policy Discussion Paper No 2. Rome: United Nations Administrative Committee on Coordination, Subcommittee on Nutrition
WHO (2011a) Guideline: vitamin A supplementation in infants and children 6–59 months of age. World Health Organization, Geneva
WHO (2011b) Guideline: use of multiple micronutrient powders for home fortification of foods consumed by infants and children 6-23 months of age. World Health Organization, Geneva. http://whqlibdoc.who.int/publications/2011/9789241502047_eng.pdf
WHO (2018) Guideline: fortification of rice with vitamins and minerals as a public health strategy. WHO, Geneva
WHO, FAO (2006) Guidelines on food fortification with micronutrients. WHO Press, Geneva
Zimmermann MB, Andersson M (2021) Global perspectives in endocrinology: coverage of iodized salt programs and iodine status in 2020. Eur J Endocrinol 185:R13–R21
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 National Academy of Agricultural Sciences, under exclusive license to Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Nair, K.M. (2023). Combating Micronutrient Deficiencies: Pharmaceuticals and Food Fortification. In: Bansal, K.C., Lakra, W.S., Pathak, H. (eds) Transformation of Agri-Food Systems . Springer, Singapore. https://doi.org/10.1007/978-981-99-8014-7_9
Download citation
DOI: https://doi.org/10.1007/978-981-99-8014-7_9
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-99-8013-0
Online ISBN: 978-981-99-8014-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)