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Role of FNA Cytology in Preoperative Prediction of NIFTP: Practical Experiences in North America

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Thyroid FNA Cytology

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Abstract

The Endocrine Pathology Society Working Group developed the nomenclature of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) to replace the previously known noninvasive encapsulated follicular variant of papillary thyroid carcinoma (FVPTC). The histologic criteria for diagnosing NIFTP was firstly refined in 2016 and then revised in 2018. This chapter reviews and discusses the experiences of presurgical cytologic assessment of histology-confirmed NIFTP in North America, including distribution of NIFTP across the categories outlined in The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) and its potential impact on risk of malignancy (ROM) among the TBSRTC categories, as well as molecular profiles of NIFTP revealed by the commercially available molecular tests, which are utilized as an adjunct to cytology.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Michigan-Michigan Medicine, Ann Arbor, MI, USA

    Madelyn Lew & Xin Jing

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  1. Madelyn Lew
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  2. Xin Jing
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Correspondence to Xin Jing .

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Editors and Affiliations

  1. Department of Pathology, Cancer Genome Center & Thyroid Disease Center, Izumi City General Hospital, Izumi, Osaka, Japan

    Kennichi Kakudo

  2. Department of Pathology, Shanghai Sixth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Zhiyan Liu

  3. Department of Pathology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea (Republic of)

    Chan Kwon Jung

  4. Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Japan

    Mitsuyoshi Hirokawa

  5. Department of Pathology, Kameda Medical Center, Kamogawa, Japan

    Andrey Bychkov

  6. Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

    Chiung-Ru Lai

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Lew, M., Jing, X. (2023). Role of FNA Cytology in Preoperative Prediction of NIFTP: Practical Experiences in North America. In: Kakudo, K., Liu, Z., Jung, C.K., Hirokawa, M., Bychkov, A., Lai, CR. (eds) Thyroid FNA Cytology. Springer, Singapore. https://doi.org/10.1007/978-981-99-6782-7_41

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  • DOI: https://doi.org/10.1007/978-981-99-6782-7_41

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-99-6781-0

  • Online ISBN: 978-981-99-6782-7

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