Abstract
Cancer of the oral cavity is one of the most common malignancies, especially in developing countries but also in the developed world. Squamous cell carcinoma (SCC) is the most common histology, and the main etiological factors are tobacco and alcohol use. Although early diagnosis is relatively easy, presentation with advanced disease is not uncommon. The standard of care is primary surgical resection with or without postoperative adjuvant therapy. Surgery remains the mainstay for nearly all tumours of the oral cavity. On the other hand, non-surgical approaches have shown equally effective tumour control and better functional outcomes in selected patients with tumours of the oropharynx. Multiple surgical approaches have been described for resection of primary oral cavity tumours, including peroral, mandibulotomy, lower cheek flap, visor flap and upper cheek flap approaches. The selection of a particular approach depends on several factors, including the tumour size and site, depth of infiltration and proximity to the mandible or maxilla. The principles of an adequate oncological resection should not be compromised by efforts to minimise the extent of the procedure. Improvements in surgical techniques combined with the routine use of postoperative radiation or chemoradiation therapy have resulted in improved survival statistics over the past decade. Successful treatment of patients with oral cancer is predicated on multidisciplinary treatment strategies to maximise oncologic control and minimise the impact of therapy on form and function.
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References
Amin MB, Edge S, Greene F, Byrd DR, Brookland RK, Washington MK, et al., editors. AJCC cancer staging manual. 8th ed. Springer International Publishing; 2017; https://www.springer.com/in/book/9783319406176.
Maghami E, Ismaila N, Alvarez A, Chernock R, Duvvuri U, Geiger J, et al. Diagnosis and Management of Squamous Cell Carcinoma of unknown primary in the head and neck: ASCO guideline. J Clin Oncol. 2020;38(22):2570–96.
Rennemo E, Zätterström U, Boysen M. Synchronous second primary tumors in 2,016 head and neck cancer patients: role of symptom-directed panendoscopy. Laryngoscope. 2011;121(2):304–9.
Yang G, Wei L, Thong BKS, Fu Y, Cheong IH, Kozlakidis Z, et al. A systematic review of Oral biopsies, sample types, and detection techniques applied in relation to Oral cancer detection. Biotech. 2022;11(1):5.
S T, R S, Ji B, Sk G, J S, Tm J. Fine-needle aspiration cytology in a regional head and neck cancer center: comparison with a systematic review and meta-analysis. Head Neck. 2008;30(9):1246; https://pubmed.ncbi.nlm.nih.gov/18528906/.
Feldhaus FW, Böning G, Kahn J, Fehrenbach U, Maurer M, Renz D, et al. Improvement of image quality and diagnostic confidence using smart MAR – a projection-based CT protocol in patients with orthopedic metallic implants in hip, spine, and shoulder. Acta Radiol. 2020;61(10):1421–30.
Weissman JL, Carrau RL. “Puffed-cheek” CT improves evaluation of the oral cavity. AJNR Am J Neuroradiol. 2001;22(4):741–4.
Mahajan A, Agarwal U, Patil VM, Patil V, Vaish R, Noronha V, et al. Proposed sub-compartmentalization of high infratemporal fossa involvement in gingivobuccal cancers and its impact on clinical outcome and staging: a narrative review. Cancer Res Stat Treat. 2022;5(2):269.
Anzai Y, Brunberg JA, Lufkin RB. Imaging of nodal metastases in the head and neck. J Magn Reson Imaging JMRI. 1997;7(5):774–83.
Merritt RM, Williams MF, James TH, Porubsky ES. Detection of cervical metastasis. A meta-analysis comparing computed tomography with physical examination. Arch Otolaryngol Head Neck Surg. 1997;123(2):149–52.
Sakata K, Hareyama M, Tamakawa M, Oouchi A, Sido M, Nagakura H, et al. Prognostic factors of nasopharynx tumors investigated by MR imaging and the value of MR imaging in the newly published TNM staging. Int J Radiat Oncol Biol Phys. 1999;43(2):273–8.
Arya S, Chaukar D, Pai P. Imaging in oral cancers. Indian J Radiol Imaging. 2012;22(3):195–208.
Mehanna H, Wong WL, McConkey CC, Rahman JK, Robinson M, Hartley AGJ, et al. PET-CT surveillance versus neck dissection in advanced head and neck cancer. N Engl J Med. 2016;374(15):1444–54.
de Koning SGB, Mb K, Cah L, Tjm R. The oral cavity tumor thickness: Measurement accuracy and consequences for tumor staging. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2019;45(11):2131–6. https://pubmed.ncbi.nlm.nih.gov/31227341/
Tang W, Wang Y, Yuan Y, Tao X. Assessment of tumor depth in oral tongue squamous cell carcinoma with multiparametric MRI: correlation with pathology. Eur Radiol. 2022;32(1):254–61.
Xu C, Yuan J, Kang L, Zhang X, Wang L, Chen X, et al. Significance of depth of invasion determined by MRI in cT1N0 tongue squamous cell carcinoma. Sci Rep. 2020;10(1):4695.
Kimura Y, Sumi M, Sakihama N, Tanaka F, Takahashi H, Nakamura T. MR imaging criteria for the prediction of Extranodal spread of metastatic cancer in the neck. Am J Neuroradiol. 2008;29(7):1355–9.
Liao CT, Wang HM, Chang JTC, Ng SH, Hsueh C, Lee LY, et al. Analysis of risk factors for distant metastases in squamous cell carcinoma of the oral cavity. Cancer. 2007;110(7):1501–8.
Troell RJ, Terris DJ. Detection of metastases from head and neck cancers. Laryngoscope. 1995;105(3 Pt 1):247–50.
Houghton DJ, Hughes ML, Garvey C, Beasley NJ, Hamilton JW, Gerlinger I, et al. Role of chest CT scanning in the management of patients presenting with head and neck cancer. Head Neck. 1998;20(7):614–8.
de Bree R, Deurloo EE, Snow GB, Leemans CR. Screening for distant metastases in patients with head and neck cancer. Laryngoscope. 2000;110(3 Pt 1):397–401.
Purohit BS, Ailianou A, Dulguerov N, Becker CD, Ratib O, Becker M. FDG-PET/CT pitfalls in oncological head and neck imaging. Insights Imaging. 2014;5(5):585–602.
Ansarin M, Bruschini R, Navach V, Giugliano G, Calabrese L, Chiesa F, et al. Classification of GLOSSECTOMIES: proposal for tongue cancer resections. Head Neck. 2019;41(3):821–7.
D’Cruz AK, Siddachari RC, Walvekar RR, Pantvaidya GH, Chaukar DA, Deshpande MS, et al. Elective neck dissection for the management of the N0 neck in early cancer of the oral tongue: need for a randomized controlled trial. Head Neck. 2009;31(5):618–24.
D’Cruz AK, Vaish R, Kapre N, Dandekar M, Gupta S, Hawaldar R, et al. Elective versus therapeutic neck dissection in node-negative Oral cancer. N Engl J Med. 2015;373(6):521–9.
Yuen APW, Ho CM, Chow TL, Tang LC, Cheung WY, Ng RWM, et al. Prospective randomized study of selective neck dissection versus observation for N0 neck of early tongue carcinoma. Head Neck. 2009;31(6):765–72.
Kligerman J, Lima RA, Soares JR, Prado L, Dias FL, Freitas EQ, et al. Supraomohyoid neck dissection in the treatment of T1/T2 squamous cell carcinoma of oral cavity. Am J Surg. 1994;168(5):391–4.
Fakih AR, Rao RS, Borges AM, Patel AR. Elective versus therapeutic neck dissection in early carcinoma of the oral tongue. Am J Surg. 1989;158(4):309–13.
Vandenbrouck C, Sancho-Garnier H, Chassagne D, Saravane D, Cachin Y, Micheau C. Elective versus therapeutic radical neck dissection in epidermoid carcinoma of the oral cavity: results of a randomized clinical trial. Cancer. 1980;46(2):386–90.
Ding Z, Xiao T, Huang J, Yuan Y, Ye Q, Xuan M, et al. Elective neck dissection versus observation in squamous cell carcinoma of Oral cavity with clinically N0 neck: a systematic review and meta-analysis of prospective studies. J Oral Maxillofac Surg. 2019;77(1):184–94.
Koyfman SA, Ismaila N, Crook D, D’Cruz A, Rodriguez CP, Sher DJ, et al. Management of the neck in squamous cell carcinoma of the oral cavity and oropharynx: ASCO Clinical Practice Guideline. J Clin Oncol. 2019;37(20):1753–74. https://doi.org/10.1200/JCO.18.01921.
Liang L, Zhang T, Kong Q, Liang J, Liao G. A meta-analysis on selective versus comprehensive neck dissection in oral squamous cell carcinoma patients with clinically node-positive neck. Oral Oncol. 2015;51(12):1076–81.
Andersen PE, Warren F, Spiro J, Burningham A, Wong R, Wax MK, et al. Results of selective neck dissection in management of the node-positive neck. Arch Otolaryngol Neck Surg. 2002;128(10):1180–4.
Colevas AD, Yom SS, Pfister DG, Spencer S, Adelstein D, Adkins D, et al. NCCN guidelines insights: head and neck cancers, version 1.2018. J Natl Compr Cancer Netw. 2018;16(5):479–90.
Bessell A, Glenny AM, Furness S, Clarkson JE, Oliver R, Conway DI, et al. Interventions for the treatment of oral and oropharyngeal cancers: surgical treatment. Cochrane Database Syst Rev. 2011;9:CD006205.
Rodrigo JP, Grilli G, Shah JP, Medina JE, Robbins KT, Takes RP, et al. Selective neck dissection in surgically treated head and neck squamous cell carcinoma patients with a clinically positive neck: systematic review. Eur J Surg Oncol. 2018;44(4):395–403.
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Nagarkar, N.M., Rao, K.N., Singh, A. (2023). Oral Cavity and Neck Dissection. In: Nagarkar, N.M., Mehta, R., Singh, A., Rao, K.N., Dange, P.S. (eds) Atlas of Head Neck and Skull-base Surgery. Springer, Singapore. https://doi.org/10.1007/978-981-99-6132-0_7
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DOI: https://doi.org/10.1007/978-981-99-6132-0_7
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