Abstract
The most morphologically and clinically varied solid epithelial tumours are salivary gland neoplasms. The current World Health Organization (WHO) classification lists 25 various forms of salivary gland tumours (Table 1). Salivary gland neoplasms exhibit a diversity that is arguably unmatched by any other organ in comparison, notwithstanding their rarity. Less than 4% of all head and neck neoplasms are salivary gland neoplasms, making them rare. The parotid gland is where most salivary gland neoplasms are found, and in adults, 80% of these are benign. Recent years have seen a clearer definition of the cytologic characteristics of salivary gland neoplasms on fine-needle aspiration, making documenting and diagnosis easier. More and more often, salivary gland tumours are found to have genomic abnormalities, such as translocations and gene fusions.
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References
Negahban S, Shirian S, Khademi B, Oryan A, Sadoughifar R, Mohammad MP, et al. The value of ultrasound-guided fine-needle aspiration cytology by cytopathologists in the diagnosis of major salivary gland tumors. J Diagn Med Sonogr. 2016;32(2):92–9.
Freling N, Crippa F, Maroldi R. Staging and follow-up of high-grade malignant salivary gland tumours: the role of traditional versus functional imaging approaches - a review. Oral Oncol. 2016;60:157–66.
Verma K, Kapila K. Role of fine needle aspiration cytology in diagnosis of pleomorphic adenomas. Cytopathology. 2002;13(2):121–7.
Shah KSV, Ethunandan M. Tumour seeding after fine-needle aspiration and core biopsy of the head and neck - a systematic review. Br J Oral Maxillofac Surg. 2016;54(3):260–5.
Rossi ED, Faquin WC, Baloch Z, Barkan GA, Foschini MP, Pusztaszeri M, et al. The Milan system for reporting salivary gland cytopathology: analysis and suggestions of initial survey. Cancer Cytopathol. 2017;125(10):757–66.
Christe A, Waldherr C, Hallett R, Zbaeren P, Thoeny H. MR imaging of parotid tumors: typical lesion characteristics in MR imaging improve discrimination between benign and malignant disease. Am J Neuroradiol. 2011;32(7):1202–7.
Yousem DM, Kraut MA, Chalian AA. Major salivary gland imaging. Radiology. 2000;216(1):19–29.
Habermann CR, Arndt C, Graessner J, Diestel L, Petersen KU, Reitmeier F, et al. Diffusion-weighted echo-planar MR imaging of primary parotid gland tumors: is a prediction of different histologic subtypes possible? Am J Neuroradiol. 2009;30(3):591–6.
Rasmussen JH, Nørgaard M, Hansen AE, Vogelius IR, Aznar MC, Johannesen HH, et al. Feasibility of multiparametric imaging with PET/MR in head and neck squamous cell carcinoma. J Nucl Med. 2017;58(1):69–74.
Thielker J, Grosheva M, Ihrler S, Wittig A, Guntinas-Lichius O. Contemporary management of benign and malignant parotid tumors. Front Surg. 2018;5:39.
Tweedie DJ, Jacob A. Surgery of the parotid gland: evolution of techniques, nomenclature and a revised classification system. Clin Otolaryngol. 2009;34(4):303–8.
Quer M, Guntinas-Lichius O, Marchal F, Vander Poorten V, Chevalier D, León X, et al. Classification of parotidectomies: a proposal of the European Salivary Gland Society. Eur Arch Otorhinolaryngol. 2016;273(10):3307–12.
Katz AD, Catalano P. The clinical significance of the various anastomotic branches of the facial nerve. Report of 100 patients. Arch Otolaryngol Head Neck Surg. 1987;113(9):959–62.
Eveson JW, Cawson RA. Salivary gland tumours. A review of 2410 cases with particular reference to histological types, site, age and sex distribution. J Pathol. 1985;146(1):51–8.
Lombardi D, McGurk M, Vander Poorten V, Guzzo M, Accorona R, Rampinelli V, et al. Surgical treatment of salivary malignant tumors. Oral Oncol. 2017;65:102–13.
Spiro RH. Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg. 1986;8(3):177–84.
Anand S, Singh H, Dash A. Clinical applications of PET and PET-CT. Med J Armed Forces India. 2009;65(4):353–8.
Daga G, Paul R, Mandal G, Kumar R. Reverse marginal Mandibulectomy for submandibular gland tumor. Int J Head Neck Surg. 2021;12(2):86–8.
Green B, Rahimi S, Brennan PA. Current management of the neck in salivary gland carcinomas. J Oral Pathol Med. 2017;46(3):161–6.
Szewczyk M, Golusiński P, Pazdrowski J, Pieńkowski P, Golusiński WJ. Management of clinically negative neck in salivary gland cancers – elective neck dissection, irradiation, or surveillance? Contemp Oncol. 2019;23(3):169–73.
Geiger JL, Ismaila N, Beadle B, Caudell JJ, Chau N, Deschler D, et al. Management of salivary gland malignancy: ASCO guideline. J Clin Oncol. 2021;39(17):1909–41.
Gold DR, Annino DJ. Management of the neck in salivary gland carcinoma. Otolaryngol Clin N Am. 2005;38(1):99–105.
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Nagarkar, N.M., Rao, K.N., Dange, P.S. (2023). Salivary Glands. In: Nagarkar, N.M., Mehta, R., Singh, A., Rao, K.N., Dange, P.S. (eds) Atlas of Head Neck and Skull-base Surgery. Springer, Singapore. https://doi.org/10.1007/978-981-99-6132-0_4
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