Abstract
Alzheimer’s disease (AD) is the most common form of dementia. With the aging of the population, dementia has become the leading cause of disability in the elderly over 65 years. Drug therapy is currently the dominant option for the treatment of AD; however, available treatment options partially contribute to delaying progression of symptoms, but can’t alter the disease course. Over the years, extensive efforts have been made to conduct trials worldwide to develop appropriate drugs. Unfortunately, drugs that have a significant impact on disease progression have not yet been discovered. Based on this fact, many scholars have begun to pay attention to non-medication regimens, including lifestyle intervention, cognitive training, and neuromodulation therapy. Among them, cognitive training related to memory and art has been found to improve cognitive symptoms to a certain extent. In recent years, more and more attention has been paid to the study of neuromodulation therapy for AD.
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References
Brighina F, Palermo A, Daniele O et al (2010) High-frequency transcranial magnetic stimulation on motor cortex of patients affected by migraine with aura: a way to restore normal cortical excitability? Cephalalgia 30(1):46–52
Cimpianu CL, Strube W, Falkai P et al (2017) Vagus nerve stimulation in psychiatry: a systematic review of the available evidence. J Neural Transm 124:145–158
De Taboada L, Yu J, El-Amouri S et al (2011) Transcranial laser therapy attenuates amyloid-beta peptide neuropathology in amyloid-beta protein precursor transgenic mice. J Alzheimers Dis 23:521–535
Felipe F, El-Hagrassy Mirret M, Kevin P-B et al (2020) Evidence-based guidelines and secondary meta-analysis for the use of transcranial direct current stimulation (tDCS) in neurological and psychiatric disorders. Int J Neuropsychopharmacol 24(4):256–313
Fini M, Tyler WJ (2017) Transcranial focused ultrasound: a new tool for non-invasive neuromodulation. Int Rev Psychiatry 29(2):168–177
Horvath JC, Forte JD, Carter O (2015) Evidence that transcranial direct current stimulation (tDCS) generates little-to-no reliable neurophysiologic effect beyond MEP amplitude modulation in healthy human subjects: a systematic review. Neuropsychologia 66:213–236
Lefaucheur JP, Aleman A, Baeken C et al (2020) Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): an update (2014-2018). Clin Neurophysiol 131(2):474–528
Michael N, Gösling M, Reutemann M et al (2002) Metabolic changes after repetitive transcranial magnetic stimulation (rTMS) of the left prefrontal cortex: a sham-controlled proton magnetic resonance spectroscopy (1H MRS) study of healthy brain. Eur J Neurosci 17(11):2462–2468
Robinson SR (2000) Neuronal expression of glutamine synthetase in Alzheimer’s disease indicates a profound impairment of metabolic interactions with astrocytes. Neurochem Int 36(4–5):471–482
Sjogren MJ, Hellstrom PT, Jonsson MA et al (2002) Cognition-enhancing effect of vagus nerve stimulation in patients with Alzheimer’s disease: a pilot study. J Clin Psychiatry 63:972–980
Tsai SR, Hamblin MR (2017) Biological effects and medical applications of infrared radiation. J Photochem Photobiol B 170:197–207
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Liu, C., Han, T., Hao, W. (2023). Dementia and Cognitive Disorders. In: Wang, Y. (eds) Therapeutics of Neural Stimulation for Neurological Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-99-4538-2_15
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DOI: https://doi.org/10.1007/978-981-99-4538-2_15
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