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Transcranial Ultrasonic Neurostimulation

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Therapeutics of Neural Stimulation for Neurological Disorders

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Abstract

Medical ultrasound is a common technology for clinical diagnosis and treatment, with the advantages of noninvasive, non-radioactive, easy and fast to use, and low equipment cost. Ultrasound is a mechanical wave that can enter the body in a noninvasive manner. During the transmission of ultrasound in the human body, echoes are generated due to the different acoustic impedances of different tissues and organs. As the echoes carry information about the difference in acoustic impedance of tissues, the echo information can be obtained to demodulate the corresponding tissue information and obtain structural images of tissues and organs to help diagnose diseases. In addition to image diagnosis, ultrasound technology has been successfully applied to the clinical treatment of tumors and other diseases, such as the elimination of lesions by thermal ablation using high-intensity ultrasound. Recent advances in ultrasound technology have enabled the application of ultrasound wave to open the blood-brain barrier in a noninvasive manner and facilitate the delivery of drugs to areas of brain diseases, which enhances the therapeutic effect of brain tumors and other diseases. In addition, studies have shown that acoustic radiation force can open mechanosensitive ion channels to modulate the electrical activity of neurons, further expanding the prospects for the application of ultrasound in the treatment of brain diseases.

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Authors and Affiliations

  1. Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

    Hairong Zheng & Lili Niu

  2. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China

    Chunyan Liu & Tingting Zhang

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  1. Hairong Zheng
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  2. Lili Niu
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  3. Chunyan Liu
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  4. Tingting Zhang
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Correspondence to Lili Niu .

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Editors and Affiliations

  1. Department of neurology, Xuanwu Hospital, Capital Medical University, Beijing, China

    Yuping Wang

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Zheng, H., Niu, L., Liu, C., Zhang, T. (2023). Transcranial Ultrasonic Neurostimulation. In: Wang, Y. (eds) Therapeutics of Neural Stimulation for Neurological Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-99-4538-2_11

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  • DOI: https://doi.org/10.1007/978-981-99-4538-2_11

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