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Appropriate Care and Post-COVID-19 Syndrome

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Gaps and Actions in Health Improvement from Hong Kong and Beyond

Abstract

Coronavirus disease 2019 (COVID-19) is caused by a new coronavirus called SARS-CoV-2 first identified in December 2019. It then became a pandemic outbreak and has been dominating activities of every country and significantly altered the form of daily life globally. In addition to its upsurge incidence rate and morbidity worldwide, the residual effects or sequelae of COVID-19 infection have been receiving more concerns including the impact on quality of life, and physical and mental health among the patients. With advancing definitions of “post-COVID-19 syndrome” by various studies, the syndrome describes an individual with a history of clinical and diagnostic SARS-CoV-2 infection with the persistence of symptoms and illness signs for more than 2–3 months which is not attributable to alternative diagnoses. The condition can be fluctuated or relapsed over time and developed into physical and mental sequelae. Despite the high incidence rate, the fatality rate is relatively low. Since there is an increasing number of patients who have recovered from COVID-19 infection but are still suffering from its complications, it is of utmost importance to identify necessary management plans and follow-up measures for the post-COVID-19 syndrome. By understanding the global situation of the post-COVID-19 syndrome, recognising the pathophysiology and clinical manifestations of the post-COVID-19 syndrome, and exploring the potential benefits gained from different post-COVID-19 management approaches, this chapter recommends a robust care plan for rehabilitation to multidisciplinary professionals in the community in the context of all for health.

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References

  • Adcock, M., Fankhauser, M., Post, J., Lutz, K., Zizlsperger, L., Luft, A. R., Guimarães, V., Schättin, A., & de Bruin, E. D. (2020). Effects of an in-home multicomponent exergame training on physical functions, cognition, and brain volume of older adults: A randomized controlled trial. Frontiers in Medicine, 6, Article 321. https://doi.org/10.3389/fmed.2019.00321

  • Addison, A. B., Wong, B., Ahmed, T., Macchi, A., Konstantinidis, I., Huart, C., Frasnelli, J., Fjaeldstad, A. W., Ramakrishnan, V. R., Rombaux, P., Whitcroft, K. L., Holbrook, E. H., Poletti, S. C., Hsieh, J. W., Landis, B. N., Boardman, J., Welge-Lüssen, A., Maru, D., Hummel, T., & Philpott, C. M. (2021). Clinical Olfactory Working Group consensus statement on the treatment of postinfectious olfactory dysfunction. Journal of Allergy and Clinical Immunology, 147(5), 1704–1719. https://doi.org/10.1016/j.jaci.2020.12.641

    Article  Google Scholar 

  • Altundag, A., Saatci, O., Sanli, D. E. T., Duz, O. A., Sanli, A. N., Olmuscelik, O., Temirbekov, D., Kandemirli, S. G., & Karaaltin, A. B. (2020). The temporal course of COVID-19 anosmia and relation to other clinical symptoms. European Archives of Oto-Rhino-Laryngology, 278(6), 1891–1897. https://doi.org/10.1007/s00405-020-06496-5

    Article  Google Scholar 

  • Augustin, M., Schommers, P., Stecher, M., Dewald, F., Gieselmann, L., Gruell, H., Horn, C., Vanshylla, K., Cristanziano, V. D., Osebold, L., Roventa, M., Riaz, T., Tschernoster, N., Altmueller, J., Rose, L., Salomon, S., Priesner, V., Luers, J. C., Albus, C., . . . Lehmann, C. (2021). Post-COVID syndrome in non-hospitalised patients with COVID-19: A longitudinal prospective cohort study. The Lancet Regional Health—Europe, 6, Article 100122. https://doi.org/10.1016/j.lanepe.2021.100122

  • Ayoubkhani, D., Bermingham, C., Pouwels, K. B., Glickman, M., Nafilyan, V., Zaccardi, F., Khunti, K., Alwan, N. A., & Walker, A. S. (2022). Trajectory of long COVID symptoms after COVID-19 vaccination: Community based cohort study. BMJ, 377, Article e069676. https://doi.org/10.1136/bmj-2021-069676

  • Bornstein, S. R., Voit-Bak, K., Donate, T., Rodionov, R. N., Gainetdinov, R. R., Tselmin, S., Kanczkowski, W., Müller, G. M., Achleitner, M., Wang, J., Licinio, J., Bauer, M., Young, A. H., Thuret, S., Bechmann, N., & Straube, R. (2021). Chronic post-COVID-19 syndrome and chronic fatigue syndrome: Is there a role for extracorporeal apheresis? Molecular Psychiatry, 27, 34–37. https://doi.org/10.1038/s41380-021-01148-4

    Article  Google Scholar 

  • Bowles, K. H., McDonald, M., Barrón, Y., Kennedy, E., O’Connor, M., & Mikkelsen, M. (2021). Surviving COVID-19 after hospital discharge: Symptom, functional, and adverse outcomes of home health recipients. Annals of Internal Medicine, 174(3), 316–325. https://doi.org/10.7326/m20-5206

    Article  Google Scholar 

  • Centers for Disease Control and Prevention. (2021, April 16). Partners. Retrieved December 17, 2021, from https://www.cdc.gov/howrightnow/partners/index.html

  • Centers for Disease Control and Prevention. (2022, April 27). Perceived exertion (Borg Rating of Perceived Exertion Scale). Retrieved 31 May 2022, from https://www.cdc.gov/physicalactivity/basics/measuring/exertion.htm

  • Centre for Health Protection. (2022, April 29). Latest situation of COVID-19 (as of 29 April 2022). https://www.chp.gov.hk/files/pdf/local_situation_covid19_en_20220429.pdf

  • Chang, P. S., Knobf, T., Oh, B., & Funk, M. (2019). Physical and psychological health outcomes of Qigong exercise in older adults: A systematic review and meta-analysis. The American Journal of Chinese Medicine, 47(2), 301–322. https://doi.org/10.1142/s0192415x19500149

    Article  Google Scholar 

  • Chen, Y., Gu, S., Chen, Y., Lu, H., Shi, D., Guo, J., Wu, W. R., Yang, Y., Li, Y., Xu, K. J., Ding, C., Luo, R., Huang, C., Yu, L., Xu, M., Yi, P., Liu, J., Tao, J. J., Zhang, H., … Li, L. (2021). Six-month follow-up of gut microbiota richness in patients with COVID-19. Gut, 71(1), 222–225. https://doi.org/10.1136/gutjnl-2021-324090

  • Chopra, V., Flanders, S. A., O’Malley, M., Malani, A. N., & Prescott, H. C. (2021). Sixty-day outcomes among patients hospitalized with COVID-19. Annals of Internal Medicine, 174(4), 576–578. https://doi.org/10.7326/m20-5661

    Article  Google Scholar 

  • Cotman, C. (2002). Exercise: A behavioral intervention to enhance brain health and plasticity. Trends in Neurosciences, 25(6), 295–301. https://doi.org/10.1016/s0166-2236(02)02143-4

    Article  Google Scholar 

  • Fadiyah, N. N., Megawati, G., & Luftimas, D. E. (2022). Potential of omega 3 supplementation for Coronavirus disease 2019 (COVID-19): A scoping review. International Journal of General Medicine, 15, 3915–3922. https://doi.org/10.2147/ijgm.s357460

    Article  Google Scholar 

  • Fernández-de-las-Peñas, C., Palacios-Ceña, D., Gómez-Mayordomo, V., Palacios-Ceña, M., Rodríguez-Jiménez, J., de-la-Llave-Rincón, A. I., Velasco-Arribas, M., Fuensalida-Novo, S., Ambite-Quesada, S., Guijarro, C., Cuadrado, M. L., Florencio, L. L., Arias-Navalón, J. A., Ortega-Santiago, R., Elvira-Martínez, C. M., Molina-Trigueros, L. J., Torres-Macho, J., Sebastián-Viana, T., Canto-Diez, M. G., … Arendt-Nielsen, L. (2022). Fatigue and dyspnoea as main persistent post-COVID-19 symptoms in previously hospitalized patients: Related functional limitations and disability. Respiration, 101(2), 132–141. https://doi.org/10.1159/000518854

    Article  Google Scholar 

  • Flores-Silva, F. D., García-Grimshaw, M., Valdés-Ferrer, S. I., Vigueras-Hernández, A. P., Domínguez-Moreno, R., Tristán-Samaniego, D. P., Michel-Chávez, A., González-Duarte, A., Vega-Boada, F. A., Reyes-Melo, I., Jiménez-Ruiz, A., Chávez-Martínez, O. A., Rebolledo-García, D., Marché-Fernández, O. A., Sánchez-Torres, S., García-Ramos, G., Cantú-Brito, C., & Chiquete, E. (2021). Neurologic manifestations in hospitalized patients with COVID-19 in Mexico City. PLoS One, 16(4), Article e0247433. https://doi.org/10.1371/journal.pone.0247433

  • Gagliardi, A., Totino, V., Cacciotti, F., Iebba, V., Neroni, B., Bonfiglio, G., Trancassini, M., Passariello, C., Pantanella, F., & Schippa, S. (2018). Rebuilding the gut microbiota ecosystem. International Journal of Environmental Research and Public Health, 15(8), Article 1679. https://doi.org/10.3390/ijerph15081679

  • George, P. M., Barratt, S. L., Condliffe, R., Desai, S. R., Devaraj, A., Forrest, I., Gibbons, M. A., Hart, N., Jenkins, R. G., McAuley, D. F., Patel, B. V., Thwaite, E., & Spencer, L. G. (2020). Respiratory follow-up of patients with COVID-19 pneumonia. Thorax, 75(11), 1009–1016. https://doi.org/10.1136/thoraxjnl-2020-215314

    Article  Google Scholar 

  • Grime, M. M., & Wright, G. (2016). Delphi method. Wiley StatsRef: Statistics Reference Online, 1–6. https://doi.org/10.1002/9781118445112.stat07879

  • Haigh, K. Z., & Gandhi, M. (2021). COVID-19 mitigation with appropriate safety measures in an essential workplace: Lessons for opening work settings in the United States during COVID-19. Open Forum Infectious Diseases, 8(4), Article ofab086. https://doi.org/10.1093/ofid/ofab086

  • Hatipoglu, S., Lyon, A. R., & Pennell, D. J. (2021). CMR unveiling the cause of post COVID-19 infection chest pain. The International Journal of Cardiovascular Imaging, 37, 2025–2026. https://doi.org/10.1007/s10554-021-02161-y

    Article  Google Scholar 

  • Hickie, I., Davenport, T., Wakefield, D., Vollmer-Conna, U., Cameron, B., Vernon, S. D., Reeves, W. C., & Lloyd, A. (2006). Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: Prospective cohort study. BMJ, 333(7568), 575. https://doi.org/10.1136/bmj.38933.585764.ae

    Article  Google Scholar 

  • Hintschich, C. A., Fischer, R., Hummel, T., Wenzel, J. J., Bohr, C., & Vielsmeier, V. (2022). Persisting olfactory dysfunction in post-COVID-19 is associated with gustatory impairment: Results from chemosensitive testing eight months after the acute infection. PLoS One, 17(3), Article e0265686. https://doi.org/10.1371/journal.pone.0265686

  • Hopkins, C., Alanin, M., Philpott, C., Harries, P., Whitcroft, K., Qureishi, A., Anari, S., Ramakrishnan, Y., Sama, A., Davies, E., Stew, B., Gane, S., Carrie, S., Hathorn, I., Bhalla, R., Kelly, C., Hill, N., Boak, D., & Nirmal Kumar, B. (2020). Management of new onset loss of sense of smell during the COVID-19 pandemic—BRS consensus guidelines. Clinical Otolaryngology, 46(1), 16–22. https://doi.org/10.1111/coa.13636

    Article  Google Scholar 

  • Huang, C., Huang, L., Wang, Y., Li, X., Ren, L., Gu, X., Kang, L., Guo, L., Liu, M., Zhou, X., Luo, J., Huang, Z., Tu, S., Zhao, Y., Chen, L., Xu, D., Li, Y., Li, C., Peng, L., … Cao, B. (2021). 6-month consequences of COVID-19 in patients discharged from hospital: A cohort study. The Lancet, 397(10270), 220–232. https://doi.org/10.1016/s0140-6736(20)32656-8

  • Janiri, D., Carfì, A., Kotzalidis, G. D., Bernabei, R., Landi, F., & Sani, G. (2021). Posttraumatic stress disorder in patients after severe COVID-19 infection. JAMA Psychiatry, 78(5), 567–569. https://doi.org/10.1001/jamapsychiatry.2021.0109

    Article  Google Scholar 

  • Kaseda, E. T., & Levine, A. J. (2020). Post-traumatic stress disorder: A differential diagnostic consideration for COVID-19 survivors. The Clinical Neuropsychologist, 34(7–8), 1498–1514. https://doi.org/10.1080/13854046.2020.1811894

    Article  Google Scholar 

  • Kruse, M. H., Durstine, A., & Evans, D. P. (2022). Effect of COVID-19 on patient access to health services for noncommunicable diseases in Latin America: A perspective from patient advocacy organizations. International Journal for Equity in Health, 21, Article 45. https://doi.org/10.1186/s12939-022-01648-x

  • Liu, J., Dong, F., & Robinson, N. (2022a). State-of-the-art evidence of traditional Chinese medicine for treating coronavirus disease 2019. Journal of Traditional Chinese Medical Sciences, 9(1), 2–6. https://doi.org/10.1016/j.jtcms.2022.01.005

    Article  Google Scholar 

  • Liu, Q., Mak, J. W. Y., Su, Q., Yeoh, Y. K., Lui, G. C. Y., Ng, S. S. S., Zhang, F., Li, A. Y. L., Lu, W., Hui, D. S. C., Chan, P. K., Chan, F. K. L., & Ng, S. C. (2022b). Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome. Gut, 71(3), 544–552. https://doi.org/10.1136/gutjnl-2021-325989

    Article  Google Scholar 

  • Lovato, A., de Filippis, C., & Marioni, G. (2020). Upper airway symptoms in coronavirus disease 2019 (COVID-19). American Journal of Otolaryngology, 41(3), Article 102474. https://doi.org/10.1016/j.amjoto.2020.102474

  • Luks, A. M., & Swenson, E. R. (2020). Pulse oximetry for monitoring patients with COVID-19 at home. Potential pitfalls and practical guidance. Annals of the American Thoracic Society, 17(9), 1040–1046. https://doi.org/10.1513/annalsats.202005-418fr

  • Mackay, A. (2021). A paradigm for post-Covid-19 fatigue syndrome analogous to ME/CFS. Frontiers in Neurology, 12, Article 701419. https://doi.org/10.3389/fneur.2021.701419

  • Malik, P., Patel, K., Pinto, C., Jaiswal, R., Tirupathi, R., Pillai, S., & Patel, U. (2021). Post-acute COVID-19 syndrome (PCS) and health-related quality of life (HRQoL)—A systematic review and meta-analysis. Journal of Medical Virology, 94(1), 253–262. https://doi.org/10.1002/jmv.27309

    Article  Google Scholar 

  • McElvaney, O. J., McEvoy, N. L., McElvaney, O. F., Carroll, T. P., Murphy, M. P., Dunlea, D. M., Ní Choileáin, O., Clarke, J., O’Connor, E., Hogan, G., Ryan, D., Sulaiman, I., Gunaratnam, C., Branagan, P., O’Brien, M. E., Morgan, R. K., Costello, R. W., Hurley, K., Walsh, S., … McElvaney, N. G. (2020). Characterization of the inflammatory response to severe COVID-19 illness. American Journal of Respiratory and Critical Care Medicine, 202(6), 812–821. https://doi.org/10.1164/rccm.202005-1583oc

  • Medrinal, C., Prieur, G., Bonnevie, T., Gravier, F. E., Mayard, D., Desmalles, E., Smondack, P., Lamia, B., Combret, Y., & Fossat, G. (2021). Muscle weakness, functional capacities and recovery for COVID-19 ICU survivors. BMC Anesthesiology, 21, Article 64. https://doi.org/10.1186/s12871-021-01274-0

  • Melman, G., Parlikad, A., & Cameron, E. (2021). Balancing scarce hospital resources during the COVID-19 pandemic using discrete-event simulation. Health Care Management Science, 24(2), 356–374. https://doi.org/10.1007/s10729-021-09548-2

    Article  Google Scholar 

  • Menges, D., Ballouz, T., Anagnostopoulos, A., Aschmann, H. E., Domenghino, A., Fehr, J. S., & Puhan, M. A. (2021). Burden of post-COVID-19 syndrome and implications for healthcare service planning: A population-based cohort study. PLOS One, 16(7), Article e0254523. https://doi.org/10.1371/journal.pone.0254523

  • Michelen, M., Manoharan, L., Elkheir, N., Cheng, V., Dagens, A., Hastie, C., O’Hara, M., Suett, J., Dahmash, D., Bugaeva, P., Rigby, I., Munblit, D., Harriss, E., Burls, A., Foote, C., Scott, J., Carson, G., Olliaro, P., Sigfrid, L., & Stavropoulou, C. (2021). Characterising long COVID: A living systematic review. BMJ Global Health, 6(9), Article e005427. https://doi.org/10.1136/bmjgh-2021-005427

  • Nalbandian, A., Sehgal, K., Gupta, A., Madhavan, M. V., McGroder, C., Stevens, J. S., Cook, J. R., Nordvig, A. S., Shalev, D., Sehrawat, T. S., Ahluwalia, N., Bikdeli, B., Dietz, D., Der-Nigoghossian, C., Liyanage-Don, N., Rosner, G. F., Bernstein, E. J., Mohan, S., Beckley, A. A., … Wan, E. Y. (2021). Post-acute COVID-19 syndrome. Nature Medicine, 27(4), 601–615. https://doi.org/10.1038/s41591-021-01283-z

  • National Health Commission of the People’s Republic of China. (2020a, March 7). Protocol on prevention and control of COVID-19 (6 ed.). http://en.nhc.gov.cn/2020a-03/29/c_78468.htm

  • National Health Commission of the People’s Republic of China. (2020b, September 7). Diagnosis and treatment protocol for COVID-19 patients (Tentative 8th ed.). http://en.nhc.gov.cn/2020-09/07/c_81565.htm

  • National Health Service. (2021). Your COVID recovery. Retrieved November 24, 2021, from https://www.yourcovidrecovery.nhs.uk/

  • National Institute for Health and Care Excellence, & Royal College of General Practitioners. (2020, December). Managing the long-term effects of COVID-19. SIGN. Retrieved November 24, 2021, from https://www.sign.ac.uk/our-guidelines/managing-the-long-term-effects-of-covid-19/

  • National Opinion Research Center at the University of Chicago. (n.d.). COVID-19 mental health communications. Retrieved December 17, 2021, from https://www.norc.org/Research/Projects/Pages/covid-19-mental-health-communications.aspx

  • Neta, F. I., Fernandes, A. C. L., Vale, A. J. M., Pinheiro, F. I., Cobucci, R. N., Azevedo, E. P. D., & Guzen, F. P. (2021). Pathophysiology and possible treatments for olfactory-gustatory disorders in patients affected by COVID-19. Current Research in Pharmacology and Drug Discovery, 2, Article 100035. https://doi.org/10.1016/j.crphar.2021.100035

  • Ng, T. K. C., Lo, M. F., Fong, B. Y. F., & Yee, H. H. L. (2022). Predictors of the intention to use traditional Chinese medicine (TCM) using extended theory of planned behavior: A cross-sectional study among TCM users in Hong Kong. BMC Complementary Medicine and Therapies, 22, Article 113. https://doi.org/10.1186/s12906-022-03598-x

  • Obokata, M., Reddy, Y. N., Melenovsky, V., Kane, G. C., Olson, T. P., Jarolim, P., & Borlaug, B. A. (2018). Myocardial injury and cardiac reserve in patients with heart failure and preserved ejection fraction. Journal of the American College of Cardiology, 72(1), 29–40. https://doi.org/10.1016/j.jacc.2018.04.039

    Article  Google Scholar 

  • Phelan, D., Kim, J. H., & Chung, E. H. (2020). A game plan for the resumption of sport and exercise after Coronavirus disease 2019 (COVID-19) infection. JAMA Cardiology, 5(10), 1085–1086. https://doi.org/10.1001/jamacardio.2020.2136

    Article  Google Scholar 

  • Polidoro, R. B., Hagan, R. S., de Santis Santiago, R., & Schmidt, N. W. (2020). Overview: Systemic inflammatory response derived from lung injury caused by SARS-CoV-2 infection explains severe outcomes in COVID-19. Frontiers in Immunology, 11, Article 1626. https://doi.org/10.3389/fimmu.2020.01626

  • Puntmann, V. O., Carerj, M. L., Wieters, I., Fahim, M., Arendt, C., Hoffmann, J., Shchendrygina, A., Escher, F., Vasa-Nicotera, M., Zeiher, A. M., Vehreschild, M., & Nagel, E. (2020). Outcomes of cardiovascular magnetic resonance imaging in patients recently recovered from Coronavirus disease 2019 (COVID-19). JAMA Cardiology, 5(11), 1265–1273. https://doi.org/10.1001/jamacardio.2020.3557

    Article  Google Scholar 

  • Rizvi, A., Patel, Z., Liu, Y., Satapathy, S. K., Sultan, K., & Trindade, A. J. (2021). Gastrointestinal Sequelae 3 and 6 months after hospitalization for Coronavirus disease 2019. Clinical Gastroenterology and Hepatology, 19(11), 2438–2440. https://doi.org/10.1016/j.cgh.2021.06.046

    Article  Google Scholar 

  • Salman, D., Vishnubala, D., le Feuvre, P., Beaney, T., Korgaonkar, J., Majeed, A., & McGregor, A. H. (2021). Returning to physical activity after COVID-19. BMJ, 372, Article m4721. https://doi.org/10.1136/bmj.m4721

  • Savikangas, T., Törmäkangas, T., Tirkkonen, A., Alen, M., Fielding, R. A., Kivipelto, M., Rantalainen, T., Stigsdotter Neely, A., & Sipilä, S. (2021). The effects of a physical and cognitive training intervention vs. physical training alone on older adults’ physical activity: A randomized controlled trial with extended follow-up during COVID-19. PLoS One, 16(10), Article e0258559. https://doi.org/10.1371/journal.pone.0258559

  • Sharma, A., Ahmad Farouk, I., & Lal, S. K. (2021). COVID-19: A review on the novel coronavirus disease evolution, transmission, detection, control and prevention. Viruses, 13(2), Article 202. https://doi.org/10.3390/v13020202

  • Strain, W. D., Sherwood, O., Banerjee, A., van der Togt, V., Hishmeh, L., & Rossman, J. (2022). The impact of COVID vaccination on symptoms of long COVID: An international survey of people with lived experience of long COVID. Vaccines, 10(5), Article 652. https://doi.org/10.3390/vaccines10050652

  • Sudre, C. H., Murray, B., Varsavsky, T., Graham, M. S., Penfold, R. S., Bowyer, R. C., Pujol, J. C., Klaser, K., Antonelli, M., Canas, L. S., Molteni, E., Modat, M., Jorge Cardoso, M., May, A., Ganesh, S., Davies, R., Nguyen, L. H., Drew, D. A., Astley, C. M., … Steves, C. J. (2021). Attributes and predictors of long COVID. Nature Medicine, 27(4), 626–631. https://doi.org/10.1038/s41591-021-01292-y

  • Tham, A. C., Thein, T. L., Lee, C. S., Tan, G. S. E., Manauis, C. M., Siow, J. K., Leo, Y. S., & Lim, M. Y. (2020). Olfactory taste disorder as a presenting symptom of COVID-19: A large single-center Singapore study. European Archives of Oto-Rhino-Laryngology, 278(6), 1853–1862. https://doi.org/10.1007/s00405-020-06455-0

    Article  Google Scholar 

  • Thams, F., Antonenko, D., Fleischmann, R., Meinzer, M., Grittner, U., Schmidt, S., Brakemeier, E. L., Steinmetz, A., & Flöel, A. (2022). Neuromodulation through brain stimulation-assisted cognitive training in patients with post-COVID-19 cognitive impairment (Neuromod-COV): Study protocol for a PROBE phase IIb trial. BMJ Open, 12(4), Article e055038. https://doi.org/10.1136/bmjopen-2021-055038

  • The Government of the Hong Kong Special Administrative Region. (2022a, March 9). Hospital authority enhances support for COVID-19 patients in community [Press release]. https://www.info.gov.hk/gia/general/202203/09/P2022030800381.htm

  • The Government of the Hong Kong Special Administrative Region. (2022b, March 12). Using a pulse oximeter at home for persons tested positive for COVID-19. Retrieved April 29, 2022, from https://www.coronavirus.gov.hk/pdf/po_covid_EN.pdf

  • The Lancet. (2020). Facing up to long COVID. The Lancet, 396(10266), 1861. https://doi.org/10.1016/s0140-6736(20)32662-3

    Article  Google Scholar 

  • Theoharides, T. C., Cholevas, C., Polyzoidis, K., & Politis, A. (2021). Long-COVID syndrome-associated brain fog and chemofog: Luteolin to the rescue. BioFactors, 47(2), 232–241. https://doi.org/10.1002/biof.1726

    Article  Google Scholar 

  • Thomas, P., Baldwin, C., Bissett, B., Boden, I., Gosselink, R., Granger, C. L., Hodgson, C., Jones, A. Y., Kho, M. E., Moses, R., Ntoumenopoulos, G., Parry, S. M., Patman, S., & van der Lee, L. (2020). Physiotherapy management for COVID-19 in the acute hospital setting: Clinical practice recommendations. Journal of Physiotherapy, 66(2), 73–82. https://doi.org/10.1016/j.jphys.2020.03.011

    Article  Google Scholar 

  • Tian, Y., Sun, K. Y., Meng, T. Q., Ye, Z., Guo, S. M., Li, Z. M., Xiong, C. L., Yin, Y., Li, H. G., & Zhou, L. Q. (2021). Gut microbiota may not be fully restored in recovered COVID-19 patients after 3-month recovery. Frontiers in Nutrition, 8, Article 638825. https://doi.org/10.3389/fnut.2021.638825

  • Vacaras, V., Frunze, S., & Cordos, A. M. (2021). Neurological complications in COVID-19—A diagnostic challenge. Journal of Medicine and Life, 14(2), 216–224. https://doi.org/10.25122/jml-2021-0045

  • van Gassel, R. J. J., Bels, J. L. M., Raafs, A., van Bussel, B. C. T., van de Poll, M. C. G., Simons, S. O., van der Meer, L. W. L., Gietema, H. A., Posthuma, R., & van Santen, S. (2021). High prevalence of pulmonary sequelae at 3 months after hospital discharge in mechanically ventilated survivors of COVID-19. American Journal of Respiratory and Critical Care Medicine, 203(3), 371–374. https://doi.org/10.1164/rccm.202010-3823le

    Article  Google Scholar 

  • Vanichkachorn, G., Newcomb, R., Cowl, C. T., Murad, M. H., Breeher, L., Miller, S., Trenary, M., Neveau, D., & Higgins, S. (2021). Post–COVID-19 syndrome (Long haul syndrome): Description of a multidisciplinary clinic at mayo clinic and characteristics of the initial patient cohort. Mayo Clinic Proceedings, 96(7), 1782–1791. https://doi.org/10.1016/j.mayocp.2021.04.024

    Article  Google Scholar 

  • Vasiliadis, A. V., & Boka, V. (2021). Safe return to exercise after COVID-19 infection. Sultan Qaboos University Medical Journal, 21(3), 373–377. https://doi.org/10.18295/squmj.8.2021.124

  • Wallström, S., & Ekman, I. (2018). Person-centred care in clinical assessment. European Journal of Cardiovascular Nursing, 17(7), 576–579. https://doi.org/10.1177/1474515118758139

  • Weng, J., Li, Y., Li, J., Shen, L., Zhu, L., Liang, Y., Lin, X., Jiao, N., Cheng, S., Huang, Y., Zou, Y., Yan, G., Zhu, R., & Lan, P. (2021). Gastrointestinal sequelae 90 days after discharge for COVID-19. The Lancet Gastroenterology & Hepatology, 6(5), 344–346. https://doi.org/10.1016/s2468-1253(21)00076-5

    Article  Google Scholar 

  • World Health Organization. (2020, June 25). Support for rehabilitation: Self-management after COVID-19 related illness. https://www.who.int/publications/m/item/support-for-rehabilitation-self-management-after-covid-19-related-illness

  • World Health Organization. (2021a, October 6). A clinical case definition of post COVID-19 condition by a Delphi consensus. https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021.1

  • World Health Organization. (2021b, November 23). Living guidance for clinical management of COVID-19. https://www.who.int/publications/i/item/WHO-2019-nCoV-clinical-2021-2

  • World Health Organization. (2022a). Timeline: WHO’s COVID-19 response. Retrieved May 1, 2022, from https://www.who.int/emergencies/diseases/novel-coronavirus-2019/interactive-timeline

  • World Health Organization. (2022b, March 31). WHO expert meeting on evaluation of traditional Chinese medicine in the treatment of COVID-19. https://www.who.int/publications/m/item/who-expert-meeting-on-evaluation-of-traditional-chinese-medicine-in-the-treatment-of-covid-19

  • World Health Organization. (2022c, April 27). Weekly epidemiological update on COVID-19—27 April 2022. https://www.who.int/docs/default-source/coronaviruse/situation-reports/2022c0427_weekly_epi_update_89.pdf?sfvrsn=e948ab5a_3&download=true

  • Zhao, S., Feng, P., Meng, W., Jin, W., Li, X., & Li, X. (2022). Modulated gut microbiota for potential COVID-19 prevention and treatment. Frontiers in Medicine, 9, Article 811176. https://doi.org/10.3389/fmed.2022.811176

  • Zhao, Y. M., Shang, Y. M., Song, W. B., Li, Q. Q., Xie, H., Xu, Q. F., Jia, J. L., Li, L. M., Mao, H. L., Zhou, X. M., Luo, H., Gao, Y. F., & Xu, A. G. (2020). Follow-up study of the pulmonary function and related physiological characteristics of COVID-19 survivors three months after recovery. EClinicalMedicine, 25, Article 100463. https://doi.org/10.1016/j.eclinm.2020.100463

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Li, L.W., Ho, W.T.P., Wong, P.Y.C. (2023). Appropriate Care and Post-COVID-19 Syndrome. In: Fong, B.Y.F., Wong, W.C.W. (eds) Gaps and Actions in Health Improvement from Hong Kong and Beyond. Springer, Singapore. https://doi.org/10.1007/978-981-99-4491-0_10

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