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Nature of Regulatory Genome: The Evolution and Natural Selection of “Genotope”

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The Topological Model of Genome and Evolution

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Abstract

In the preceding chapters, several aspects of genomics were deconstructed using the formalism of involuted manifolds. It was demonstrated that several hitherto unknown features of genomic architecture could be explicated and formalized using involutive algebras. As a culmination of these insights into the nature of genomic architecture, we will formalize a topological modular framework of genomes which consists of formal higher dimensional units of genomes to be christened as “GENOTOPE.” In this chapter, we will outline an evolutionary and a functional outline of this model. This model necessarily involves a higher dimensional manifold which runs contrary to the four-dimensional spacetime in which the biological evolution has taken place. Therefore, an outline of the reasons why these extra dimensions are required and why they are connected with one another through an operator of involution will be discussed. A topological framework of natural selection using this operator of involution will be presented. We will discuss why genomes should exist both as ecosystems as well as the units of selection.

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Authors and Affiliations

  1. Independent Technical Advisor, Mumbai, Maharashtra, India

    Pradeep Chhaya

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  1. Pradeep Chhaya
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Chhaya, P. (2023). Nature of Regulatory Genome: The Evolution and Natural Selection of “Genotope”. In: The Topological Model of Genome and Evolution. Springer, Singapore. https://doi.org/10.1007/978-981-99-4318-0_8

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