Abstract
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy based on its clinical features, underlying pathogenesis, and treatment outcomes. Recent advances in genomic sequencing have revealed the molecular complexity of AML leukemogenesis, thereby resulting in the refinement of risk stratification, prognostication, and personalized therapeutic strategies for patients with AML. Annotation of the mutational landscape in AML has markedly facilitated the refinement of the current classification and risk stratification systems. In this chapter, we summarize the most relevant genetic markers in AML, with a special focus on the prognostic relevance and risk stratification of these aberrations.
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Acknowledgments
This work was supported by grants from the Ministry of Science and Technology (MOST 111-2314-B-002-279, Taiwan) and Ministry of Health and Welfare (MOHW 107-TDU-B-211-114009 and 111-TDU-B-221-114001, Taiwan).
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Contribution: HA Hou reviewed the literature and wrote the manuscript.
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Hou, HA. (2023). Genomic Landscape and Risk Stratification of Acute Myeloid Leukemia. In: Gill, H., Kwong, YL. (eds) Pathogenesis and Treatment of Leukemia. Springer, Singapore. https://doi.org/10.1007/978-981-99-3810-0_5
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