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Management of Older Patients with Acute Lymphoblastic Leukemia

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Pathogenesis and Treatment of Leukemia

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Abstract

Although substantial progress is achieved in ALL total therapy in adolescent young adults and adults, marginal improvements in survival over time in older patients present a great challenge. Older patients often carry high-risk genetic lesions that confer resistance to conventional chemotherapy, and a higher incidences of comorbidities and impaired performance status limit their tolerance to receive the same intensity as younger patients, such as hematopoietic stem cell transplantation. In this chapter, we review the current treatment of older ALL patients with good performance.

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Author information

Authors and Affiliations

  1. State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Shanghai Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Xiao-Xia Hu

  2. Department of Hematology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

    Hong-Hu Zhu

Authors
  1. Xiao-Xia Hu
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  2. Hong-Hu Zhu
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Correspondence to Hong-Hu Zhu .

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Editors and Affiliations

  1. Department of Medicine, Queen Mary Hospital, Hongkong, Hong Kong

    Harinder Gill

  2. Department of Medicine, Queen Mary Hospital, Hongkong, Hong Kong

    Yok-Lam Kwong

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© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Hu, XX., Zhu, HH. (2023). Management of Older Patients with Acute Lymphoblastic Leukemia. In: Gill, H., Kwong, YL. (eds) Pathogenesis and Treatment of Leukemia. Springer, Singapore. https://doi.org/10.1007/978-981-99-3810-0_21

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  • DOI: https://doi.org/10.1007/978-981-99-3810-0_21

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-99-3809-4

  • Online ISBN: 978-981-99-3810-0

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