Abstract
Mitochondrial activity is fundamental to supporting cellular metabolisms of almost all types of body cells. This carries paramount significance for the treatment of AML due to the presence of mitochondrial abnormalities, which can be exploited for selective AML cells targeting. In addition, other aberrant metabolic pathways discovered in LSCs are also being explored as targets for LSC eradication. In this chapter, we discuss the roles of IDH1 and IDH2 inhibitors in targeting the metabolic pathways in AML.
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Gill, H. (2023). Role of IDH1/IDH2 Inhibitors in AML. In: Gill, H., Kwong, YL. (eds) Pathogenesis and Treatment of Leukemia. Springer, Singapore. https://doi.org/10.1007/978-981-99-3810-0_11
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DOI: https://doi.org/10.1007/978-981-99-3810-0_11
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