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Basic Hematopoiesis and Leukemia Stem Cells

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Pathogenesis and Treatment of Leukemia

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Abstract

There have been significant advances in the knowledge and understanding of hematopoiesis over the last century. Detailed functional, phenotypic, and genetic studies on hematopoietic stem and progenitor cells as well as cellular subsets have facilitated efforts in the diagnosis and prognostication of various diseases of the bone marrow. Identification of myriad cellular pathways has also facilitated the development of new drugs for the treatment of these diseases, especially for the blood cancers. Current development of novel techniques for the expansion and genetic modification of hematopoietic stem cells, mesenchymal stromal cells, and immune cells will further expand the toolbox for treating patients with otherwise fatal cancers and bone marrow diseases.

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Authors and Affiliations

  1. National Cancer Centre Singapore, Singapore, Singapore

    William Y. K. Hwang, Sudipto Bari, Lai Guan Ng, Koji Itahana, Shang Li & Hein Than

  2. Singapore General Hospital, Singapore, Singapore

    William Y. K. Hwang & Hein Than

  3. Duke-NUS Medical School, Singapore, Singapore

    William Y. K. Hwang, Sudipto Bari, Koji Itahana, Shang Li & Javier Yu Peng Koh

  4. Advanced Cell Therapy and Research Institute, Singapore, Singapore

    Sudipto Bari

  5. A* Singapore Immunology Network (A* SIgN), Singapore, Singapore, Singapore

    Lai Guan Ng

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  1. William Y. K. Hwang
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  7. Hein Than
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Correspondence to William Y. K. Hwang .

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  1. Department of Medicine, Queen Mary Hospital, Hongkong, Hong Kong

    Harinder Gill

  2. Department of Medicine, Queen Mary Hospital, Hongkong, Hong Kong

    Yok-Lam Kwong

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Hwang, W.Y.K. et al. (2023). Basic Hematopoiesis and Leukemia Stem Cells. In: Gill, H., Kwong, YL. (eds) Pathogenesis and Treatment of Leukemia. Springer, Singapore. https://doi.org/10.1007/978-981-99-3810-0_1

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  • DOI: https://doi.org/10.1007/978-981-99-3810-0_1

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