Abstract
Chapter 7 mentioned that there is a deep relationship between inflammation and cancer, which are regulated by microRNAs (miRNAs). Although inflammation is also implicated in the immune response, both of which can be controlled by miRNAs, autoimmune diseases such as inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) do not usually induce tumorigenesis. Ulcerative colitis (UC) and Crohn’s disease (CD) are commonly included in IBD. UC causes chronic inflammation of the colonic mucosa, and CD features transmural inflammation that occurs in many portions of the gut from the mouth to the anus. RA is also characterized by chronic inflammation as a consequence of sustained synovitis and progressive and irreversible joint damage. Therefore, patients with RA have pain, swelling, and stiffness in multiple joints bilaterally. To further understand the relationship between inflammation and cancer, the pathogenesis of IBD and RA was simulated by miRNA entangling target sorting (METS)/miRNA quantum language and artificial intelligence (MIRAI) using circulating miRNA biomarkers.
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Asimov I
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Fujii, Y.R. (2023). Inflammatory Bowel Disease and Rheumatoid Arthritis. In: The MicroRNA 2000 Transformer. Springer, Singapore. https://doi.org/10.1007/978-981-99-3165-1_12
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