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Microbial Diversity and Their Role in Human Health and Diseases

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Role of Microbes in Sustainable Development

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Abstract

Micro-organisms are as old as human civilization and have co-evolved with human beings by inhabiting either inside or outside their body for deriving food and nutrition. Since time immemorial, these tiny animals/microbes have played a vital role in human health both in positive and negative manners. There is a close association between human health and microbial disease; however, the survival of these microbes/pathogens in the bodies of human beings gets affected in several ways, one of which is an environmental factor that immensely interferes with human–microbial interaction. Modern studies/research on micro-organisms affecting human health have become much more refined and inclusive. Therefore, in depth research should be conducted on the human–microbe interactions that may lead to understanding the role of microbiota inhuman health and disease and provide new therapeutic goals and treatment approaches in clinical practices. The present chapter has been designed to summarize the role of human health in the development of major human diseases, such as liver diseases, gastrointestinal, metabolic, respiratory, mental or psychological, and autoimmune disorders.

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References

  • Abnet CC, Arnold M, Wei WQ (2018) Epidemiology of esophageal squamous cell carcinoma. Gastroenterology 154(2):360–373

    Article  PubMed  Google Scholar 

  • Aguilar-Toalá JE, Garcia-Varela R, Garcia HS, Mata-Haro V, González-CĂłrdova AF, Vallejo-Cordoba B, Hernández-Mendoza A (2018) Postbiotics: an evolving term within the functional foods field. Trends Food Sci Technol 75:105–114

    Article  Google Scholar 

  • AlarcĂłn T, Llorca L, Perez-Perez G (2017) Impact of the microbiota and gastric disease development by Helicobacter pylori. Curr Top Microbiol Immunol 400:253–275

    PubMed  Google Scholar 

  • Almeida A, Mitchell AL, Boland M, Forster SC, Gloor GB, Tarkowska A, Lawley TD, Finn RD (2019) A new genomic blueprint of the human gut microbiota. Nature 568(7753):499–504

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ames BN, Gold LS (1998) The causes and prevention of cancer: the role of environment. Biotherapy 11(2):205–220

    Article  CAS  PubMed  Google Scholar 

  • Andrici J, Eslick GD (2015) Hot food and beverage consumption and the risk of esophageal cancer: a meta-analysis. Am J Prev Med 49(6):952–960

    Article  PubMed  Google Scholar 

  • Arnold M, Soerjomataram I, Ferlay J, Forman D (2015) Global incidence of oesophageal cancer by histological subtype in 2012. Gut 64(3):381–387

    Article  PubMed  Google Scholar 

  • Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, Fernandes GR, Tap J, Bruls T, Batto JM, Bertalan M (2011) Erratum: enterotypes of the human gut microbiome (Nature (2011) 473 (174-180)). Nature 474(7353):666

    Article  CAS  Google Scholar 

  • Arweiler NB, Netuschil L (2016) The oral microbiota. Adv Exp Med Biol 902:45–60

    Article  PubMed  Google Scholar 

  • Babu G, Singaravelu BG, Srikumar R, Reddy SV (2017) Comparative study on the vaginal flora and incidence of asymptomatic vaginosis among healthy women and in women with infertility problems of reproductive age. J Clin Diagn Res 11(8):DC18

    PubMed  PubMed Central  Google Scholar 

  • Bajaj JS, Betrapally NS, Hylemon PB, Heuman DM, Daita K, White MB, Unser A, Thacker LR, Sanyal AJ, Kang DJ, Sikaroodi M (2015) Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy. Hepatology 62(4):1260–1271

    Article  CAS  PubMed  Google Scholar 

  • Bajaj JS, Betrapally NS, Hylemon PB, Thacker LR, Daita K, Kang DJ, White MB, Unser AB, Fagan A, Gavis EA, Sikaroodi M (2015) Gut microbiota alterations can predict hospitalizations in cirrhosis independent of diabetes mellitus. Sci Rep 5(1):1–9

    Article  Google Scholar 

  • Bajaj JS, Hylemon PB, Ridlon JM, Heuman DM, Daita K, White MB, Monteith P, Noble NA, Sikaroodi M, Gillevet PM (2012) Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation. Am J Physiol Gastrointest Liver Physiol 303(6):G675–G685

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bajaj JS, Liu EJ, Kheradman R, Fagan A, Heuman DM, White M, Gavis EA, Hylemon P, Sikaroodi M, Gillevet PM (2018) Fungal dysbiosis in cirrhosis. Gut 67(6):1146–1154

    Article  CAS  PubMed  Google Scholar 

  • Bataller R, Arteel GE, Moreno C, Shah V (2019) Alcohol-related liver disease: time for action. J Hepatol 70(2):221–222

    Article  PubMed  PubMed Central  Google Scholar 

  • Becerril-Rico J, Alvarado-Ortiz E, Toledo-Guzmán ME, Pelayo R, Ortiz-Sánchez E (2021) The cross talk between gastric cancer stem cells and the immune microenvironment: a tumor-promoting factor. Stem Cell Res Ther 12(1):1–14

    Article  Google Scholar 

  • Becker S, Dossus L, Kaaks R (2009) Obesity related hyperinsulinaemia and hyperglycaemia and cancer development. Arch Physiol Biochem 115(2):86–96

    Article  CAS  PubMed  Google Scholar 

  • Bergheim I, Weber S, Vos M, Krämer S, Volynets V, Kaserouni S, McClain CJ, Bischoff SC (2008) Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin. J Hepatol 48(6):983–992

    Article  CAS  PubMed  Google Scholar 

  • Bernabe BP, Cralle L, Gilbert JA (2018) Systems biology of the human microbiome. Curr Opin Biotechnol 51:146–153

    Article  Google Scholar 

  • Bosetti C, Levi F, Rosato V, Bertuccio P, Lucchini F, Negri E, La Vecchia C (2011) Recent trends in colorectal cancer mortality in Europe. Int J Cancer 129(1):180–191

    Article  CAS  PubMed  Google Scholar 

  • Bouskra D, BrĂ©zillon C, BĂ©rard M, Werts C, Varona R, Boneca IG et al (2008) Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature 456(7221):507–510

    Article  CAS  PubMed  Google Scholar 

  • Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424

    Article  PubMed  Google Scholar 

  • Breitbart M, Salamon P, Andresen B, Mahaffy JM, Segall AM, Mead D, Azam F, Rohwer F (2002) Genomic analysis of uncultured marine viral communities. Proc Natl Acad Sci U S A 99:14250–14255

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cani PD (2018) Human gut microbiome: hopes, threats and promises. Gut 67(9):1716–1725

    Article  CAS  PubMed  Google Scholar 

  • Cani PD, Delzenne NM, Amar J, Burcelin R (2008) Role of gut microflora in the development of obesity and insulin resistance following high-fat diet feeding. Pathol Biol 56(5):305–309

    Article  CAS  PubMed  Google Scholar 

  • Cani PD, Neyrinck AM, Fava F, Knauf C, Burcelin RG, Tuohy KM, Gibson GR, Delzenne NM (2007) Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 50(11):2374–2383

    Article  CAS  PubMed  Google Scholar 

  • Carding S, Verbeke K, Vipond DT, Corfe BM, Owen LJ (2015) Dysbiosis of the gut microbiota in disease. Microb Ecol Health Dis 26(1):26191

    PubMed  Google Scholar 

  • Cardoso AM (2021) Can changes in gut Microbiota predict progression toward diabetes? J Explor Res Pharmacol 6(4):168–169

    Google Scholar 

  • Cash HL, Whitham CV, Behrendt CL, Hooper LV (2006) Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 313(5790):1126–1130

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cavicchioli R, Curmi P, Saunders N, Thomas T (2003) Pathogenic archaea: do they exist? Bioessays 25:1119–1128

    Article  CAS  PubMed  Google Scholar 

  • Center MM, Jemal A, Ward E (2009) International trends in colorectal cancer incidence rates. Cancer Epidemiol Biomarkers Prev 18(6):1688–1694

    Article  PubMed  Google Scholar 

  • Chen Y, Ji F, Guo J, Shi D, Fang D, Li L (2016) Dysbiosis of small intestinal microbiota in liver cirrhosis and its association with etiology. Sci Rep 6(1):1–9

    Google Scholar 

  • Chen L, Shi Y, Zhu X, Guo W, Zhang M, Che Y, Tang L, Yang X, You Q, Liu Z (2019) IL-10 secreted by cancer-associated macrophages regulates proliferation and invasion in gastric cancer cells via c-Met/STAT3 signaling. Oncol Rep 42(2):595–604

    CAS  PubMed  PubMed Central  Google Scholar 

  • Chen C, Song X, Wei W, Zhong H, Dai J, Lan Z, Li F, Yu X, Feng Q, Wang Z, Xie H (2017) The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases. Nat Commun 8(1):1–11

    Google Scholar 

  • Clabots CR, Johnson S, Olson MM, Peterson LR, Gerding DN (1992) Acquisition of Clostridium difficile by hospitalized patients: evidence for colonized new admissions as a source of infection. J Infect Dis 166(3):561–567

    Article  CAS  PubMed  Google Scholar 

  • Cogen AL, Nizet V, Gallo RL (2008) Skin microbiota: a source of disease or defence? Br J Dermatol 158:442–455

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Coker OO, Dai Z, Nie Y, Zhao G, Cao L, Nakatsu G, Wu WK, Wong SH, Chen Z, Sung JJ, Yu J (2018) Mucosal microbiome dysbiosis in gastric carcinogenesis. Gut 67(6):1024–1032

    Article  CAS  PubMed  Google Scholar 

  • Coleman HG, Xie SH, Lagergren J (2018) The epidemiology of esophageal adenocarcinoma. Gastroenterology 154(2):390–405

    Article  PubMed  Google Scholar 

  • Cuvelier ML, Allen AE, Monier A, McCrow JP, MessiĂ© M, Tringe SG, Woyke T, Welsh RM, Ishoey T, Lee JH (2010) Targeted metagenomics and ecology of globally important uncultured eukaryotic phytoplankton. Proc Natl Acad Sci 107:14679–14684

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Czepiel J, DróżdĹĽ M, Pituch H, Kuijper EJ, Perucki W, Mielimonka A, Goldman S, WultaĹ„ska D, Garlicki A, Biesiada G (2019) Clostridium difficile infection. Eur J Clin Microbiol Infect Dis 38(7):1211–1221

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dapito DH, Mencin A, Gwak GY, Pradere JP, Jang MK, Mederacke I, Caviglia JM, Khiabanian H, Adeyemi A, Bataller R, Lefkowitch JH (2012) Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 21(4):504–516

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dávila-Collado R, JarquĂ­n-Durán O, Dong LT, Espinoza JL (2020) Epstein–Barr virus and Helicobacter pylori co-infection in non-malignant gastroduodenal disorders. Pathogens 9(2):104

    Article  PubMed  PubMed Central  Google Scholar 

  • Day CP, James OF (1998) Steatohepatitis: a tale of two “hits”? Gastroenterology 114(4):842–845

    Article  CAS  PubMed  Google Scholar 

  • den Besten G, van Eunen K, Groen AK, Venema K, Reijngoud DJ et al (2013) The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res 54:2325–2340

    Article  Google Scholar 

  • Dewhirst FE, Chen T, Izard J, Paster BJ, Tanner AC et al (2010) The human oral microbiome. J Bacteriol 192:5002–5017

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Donders GG, Vereecken A, Bosmans E, Dekeersmaecker A, Salembier G, Spitz B (2002) Definition of a type of abnormal vaginal flora that is distinct from bacterial vaginosis: aerobic vaginitis. BJOG 109(1):34–43

    Article  PubMed  Google Scholar 

  • Doorakkers E, Lagergren J, Engstrand L, Brusselaers N (2018) Helicobacter pylori eradication treatment and the risk of gastric adenocarcinoma in a Western population. Gut 67(12):2092–2096

    Article  PubMed  Google Scholar 

  • Edgren G, Adami HO, Weiderpass E, NyrĂ©n O (2013) A global assessment of the oesophageal adenocarcinoma epidemic. Gut 62(10):1406–1414

    Article  PubMed  Google Scholar 

  • Engel LS, Chow WH, Vaughan TL, Gammon MD, Risch HA, Stanford JL, Schoenberg JB, Mayne ST, Dubrow R, Rotterdam H, West AB (2003) Population attributable risks of esophageal and gastric cancers. J Natl Cancer Inst 95(18):1404–1413

    Article  PubMed  Google Scholar 

  • Eshraghian A, Taghavi A, Nikeghbalian S, Malek-Hosseini SA (2020) Reduced rate of hospital admissions for liver-related morbidities during the initial COVID-19 outbreak. Lancet Gastroenterol Hepatol 5(9):803–804

    Article  PubMed  PubMed Central  Google Scholar 

  • Espinoza JL, Matsumoto A, Tanaka H, Matsumura I (2018) Gastric microbiota: An emerging player in Helicobacter pylori-induced gastric malignancies. Cancer Lett 414:147–152

    Article  CAS  PubMed  Google Scholar 

  • Eyre DW, Griffiths D, Vaughan A, Golubchik T, Acharya M, O’Connor L, Crook DW, Walker AS, Peto TE (2013) Asymptomatic Clostridium difficile colonisation and onward transmission. PloS One 8(11):e78445

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fessler J, Matson V, Gajewski TF (2019) Exploring the emerging role of the microbiome in cancer immunotherapy. J Immunother Cancer 7(1):1–15

    Article  Google Scholar 

  • Figliuolo VR, Dos Santos LM, Abalo A, Nanini H, Santos A, Brittes NM, Bernardazzi C, de Souza HSP, Vieira LQ, Coutinho-Silva R, Coutinho CMLM (2017) Sulfate-reducing bacteria stimulate gut immune responses and contribute to inflammation in experimental colitis. Life Sci 189:29–38

    Article  CAS  PubMed  Google Scholar 

  • Finegold SM, Molitoris D, Song Y, Liu C, Vaisanen ML, Bolte E et al (2002) Gastrointestinal microflora studies in late-onset autism. Clin Infect Dis 35(Suppl 1):S6–S16

    Article  PubMed  Google Scholar 

  • Fitzmaurice C, Akinyemiju TF, Al Lami FH, Alam T, Alizadeh-Navaei R, Allen C, Alsharif U, Alvis-Guzman N, Amini E, Anderson BO, Aremu O (2018) Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2016: a systematic analysis for the global burden of disease study. JAMA Oncol 4(11):1553–1568

    Article  PubMed  Google Scholar 

  • Flood MP, Lawrentschuk N, Heriot AG (2022) Malignant gastrointestinal conditions. In: Men’s health and wellbeing. Springer, Cham, pp 331–341

    Chapter  Google Scholar 

  • Flores R, Shi J, Fuhrman B, Xu X, Veenstra TD, Gail MH, Gajer P, Ravel J, Goedert JJ (2012) Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: a cross-sectional study. J Transl Med 10(1):1–11

    Article  Google Scholar 

  • Frank DN, St. Amand AL, Feldman RA, Boedeker EC, Harpaz N, Pace NR (2007) Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci 104(34):13780–13785

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Freedman ND, Abnet CC, Leitzmann MF, Mouw T, Subar AF, Hollenbeck AR, Schatzkin A (2007) A prospective study of tobacco, alcohol, and the risk of esophageal and gastric cancer subtypes. Am J Epidemiol 165(12):1424–1433

    Article  PubMed  Google Scholar 

  • Fuerst JA (2014) Microorganisms—A Journal and a Unifying Concept for the Science of Microbiology. Microorganisms 2:140–146

    Article  PubMed  PubMed Central  Google Scholar 

  • Fuke N, Nagata N, Suganuma H, Ota T (2019) Regulation of gut microbiota and metabolic endotoxemia with dietary factors. Nutrients 11(10):2277

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gao Z, Guo B, Gao R, Zhu Q, Qin H (2015) Microbiota disbiosis is associated with colorectal cancer. Front Microbiol 6:20

    Article  PubMed  PubMed Central  Google Scholar 

  • Gill SR, Pop M, Deboy RT, Eckburg PB, Turnbaugh PJ, Samuel BS et al (2006) Metagenomic analysis of the human distal gut microbiome. Science 312(5778):1355–1359

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Giovannoni SJ, Stingl U (2005) Molecular diversity and ecology of microbial plankton. Nature 427:343–348

    Article  Google Scholar 

  • Goedert JJ, Jones G, Hua X, Xu X, Yu G, Flores R, Falk RT, Gail MH, Shi J, Ravel J, Feigelson HS (2015) Investigation of the association between the fecal microbiota and breast cancer in postmenopausal women: a population-based case-control pilot study. J Natl Cancer Inst 107(8):djv147

    Article  PubMed  PubMed Central  Google Scholar 

  • Goh YJ, Klaenhammer TR (2015) Genetic mechanisms of prebiotic oligosaccharide metabolism in probiotic microbes. Annu Rev Food Sci Technol 6:137–156

    Article  CAS  PubMed  Google Scholar 

  • GrÄ…t M, Wronka KM, KrasnodÄ™bski M, Lewandowski Z, KosiĹ„ska I, GrÄ…t K, StypuĹ‚kowski J, Rejowski S, Wasilewicz M, GaĹ‚Ä™cka M, Szachta P (2016) Profile of gut microbiota associated with the presence of hepatocellular cancer in patients with liver cirrhosis. Transplant Proc 48(5):1687–1691

    Article  PubMed  Google Scholar 

  • Grice EA, Segre JA (2011) The skin microbiome. Nat Rev Microbiol 9:244–253

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Guven-Maiorov E, Tsai CJ, Nussinov R (2017) Structural host-microbiota interaction networks. PLoS Comput Biol 13(10):e1005579

    Article  PubMed  PubMed Central  Google Scholar 

  • Haileselassie Y, Navis M, Vu N, Qazi KR, Rethi B, Sverremark-Ekström E (2016) Postbiotic modulation of retinoic acid imprinted mucosal-like dendritic cells by probiotic Lactobacillus reuteri 17938 in vitro. Front Immunol 7:96

    Article  PubMed  PubMed Central  Google Scholar 

  • Haldar S, Kapil A, Sood S, Sengupta S (2016) Female reproductive tract microbiome in gynecological health and problems. J Reprod Health Med 2:S48–S54

    Article  Google Scholar 

  • Hattori M, Taylor TD (2009) The human intestinal microbiome: a new frontier of human biology. DNA Res 16(1):1–12

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hawes SE, Hillier SL, Benedetti J, Stevens CE, Koutsky LA, Wølner-Hanssen P, Holmes KK (1996) Hydrogen peroxide—producing lactobacilli and acquisition of vaginal infections. J Infect Dis 174(5):1058–1063

    Article  CAS  PubMed  Google Scholar 

  • He FF, Li YM (2020) Role of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome: a review. J Ovarian Res 13(1):1–13

    Article  Google Scholar 

  • Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP (2012) Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482(7384):179–185

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • HoleÄŤek M (2018) Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements. Nutr Metab 15(1):1–12

    Article  Google Scholar 

  • Hollister EB, Gao C, Versalovic J (2014) Compositional and functional features of the gastrointestinal microbiome and their effects on human health. Gastroenterology 146(6):1449–1458

    Article  PubMed  Google Scholar 

  • Honda K, Littman DR (2012) The microbiome in infectious disease and inflammation. Annu Rev Immunol 30:759

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hooi JK, Lai WY, Ng WK, Suen MM, Underwood FE, Tanyingoh D, Malfertheiner P, Graham DY, Wong VW, Wu JC, Chan FK (2017) Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis. Gastroenterology 153(2):420–429

    Article  PubMed  Google Scholar 

  • Hooper LV, Stappenbeck TS, Hong CV, Gordon JI (2003) Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat Immunol 4(3):269–273

    Article  CAS  PubMed  Google Scholar 

  • Hsiao WW, Metz C, Singh DP, Roth J (2008) The microbes of the intestine: an introduction to their metabolic and signaling capabilities. Endocrinol Metab Clin North Am 37:857–871

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Huang Y, Fan XG, Wang ZM, Zhou JH, Tian XF, Li N (2004) Identification of helicobacter species in human liver samples from patients with primary hepatocellular carcinoma. J Clin Pathol 57(12):1273–1277

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hung YP, Lin HJ, Wu TC, Liu HC, Lee JC, Lee CI, Wu YH, Wan L, Tsai PJ, Ko WC (2013) Risk factors of fecal toxigenic or non-toxigenic Clostridium difficile colonization: impact of Toll-like receptor polymorphisms and prior antibiotic exposure. PloS One 8(7):e69577

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ishizaka A, Koga M, Mizutani T, Parbie PK, Prawisuda D, Yusa N, Sedohara A, Kikuchi T, Ikeuchi K, Adachi E, Koibuchi T (2021) Unique gut microbiome in HIV patients on antiretroviral therapy (ART) suggests association with chronic inflammation. Microbiol Spectr 9(1):e00708–e00721

    Article  CAS  Google Scholar 

  • Islami F, Ren JS, Taylor PR, Kamangar F (2009) Pickled vegetables and the risk of oesophageal cancer: a meta-analysis. Br J Cancer 101(9):1641–1647

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jacques Ferlay IS, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2014) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136:29

    Google Scholar 

  • Jakubovics NS, Gill SR, Vickerman MM, Kolenbrander PE (2008) Role of hydrogen peroxide in competition and cooperation between Streptococcus gordonii and Actinomyces naeslundii. FEMS MicrobiolEcol 66:637–644

    Article  CAS  Google Scholar 

  • Jansson C, Johansson AL, NyrĂ©n O, Lagergren J (2005) Socioeconomic factors and risk of esophageal adenocarcinoma: a nationwide Swedish case-control study. Cancer Epidemiol Biomarkers Prev 14(7):1754–1761

    Article  PubMed  Google Scholar 

  • Javed A, Parvaiz F, Manzoor S (2019) Bacterial vaginosis: An insight into the prevalence, alternative treatments regimen and it's associated resistance patterns. Microb Pathog 127:21–30

    Article  PubMed  Google Scholar 

  • Jin C, Lagoudas GK, Zhao C, Bullman S, Bhutkar A, Hu B, Ameh S, Sandel D, Liang XS, Mazzilli S, Whary MT (2019) Commensal microbiota promote lung cancer development via γδ T cells. Cell 176(5):998–1013

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kamangar F, Freedman ND (2018) Hot tea and esophageal cancer. Ann Intern Med 168(7):519–520

    Article  PubMed  Google Scholar 

  • Kelly SM, Crampton JR, Hunter JO (1993) Helicobacter pylori increases gastric antral juxtamucosal pH. Dig Dis Sci 38(1):129–131

    Article  CAS  PubMed  Google Scholar 

  • Khanna S, Pardi DS, Aronson SL, Kammer PP, Orenstein R, Sauver JLS, Harmsen WS, Zinsmeister AR (2012) The epidemiology of community-acquired Clostridium difficile infection: a population-based study. Am J Gastroenterol 107(1):89

    Article  PubMed  Google Scholar 

  • Kim BC, Shin A, Hong CW, Sohn DK, Han KS, Ryu KH, Park BJ, Nam JH, Park JW, Chang HJ, Choi HS (2012) Association of colorectal adenoma with components of metabolic syndrome. Cancer Causes Control 23(5):727–735

    Article  PubMed  Google Scholar 

  • Koh A, Molinaro A, StĂĄhlman M, Khan MT, Schmidt C, MannerĂĄs-Holm L, Wu H, Carreras A, Jeong H, Olofsson LE, Bergh PO (2018) Microbially produced imidazole propionate impairs insulin signaling through mTORC1. Cell 175(4):947–961

    Article  CAS  PubMed  Google Scholar 

  • Kumar S, Patel GK, Ghoshal UC (2021) Helicobacter pylori-induced inflammation: possible factors modulating the risk of gastric cancer. Pathogens 10(9):1099

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kwa M, Plottel CS, Blaser MJ, Adams S (2016) The intestinal microbiome and estrogen receptor–positive female breast cancer. J Natl Cancer Inst 108(8):djw029

    PubMed  PubMed Central  Google Scholar 

  • Kwak Y, Seo AN, Lee HE, Lee HS (2020) Tumor immune response and immunotherapy in gastric cancer. J Pathol Trans Med 54(1):20–33

    Article  Google Scholar 

  • Lagergren J, Smyth E, Cunningham D, Lagergren P (2017) Oesophageal cancer. Lancet 390(10110):2383–2396

    Article  PubMed  Google Scholar 

  • Lambertucci F, Arboatti A, Sedlmeier MG, Motiño O, de Luján Alvarez M, Ceballos MP, Villar SR, Roggero E, Monti JA, Pisani G, Quiroga AD (2018) Disruption of tumor necrosis factor alpha receptor 1 signaling accelerates NAFLD progression in mice upon a high-fat diet. J Nutr Biochem 58:17–27

    Article  CAS  PubMed  Google Scholar 

  • Lang S, Demir M, Martin A, Jiang L, Zhang X, Duan Y, Gao B, Wisplinghoff H, Kasper P, Roderburg C, Tacke F (2020) Intestinal virome signature associated with severity of nonalcoholic fatty liver disease. Gastroenterology 159(5):1839–1852

    Article  CAS  PubMed  Google Scholar 

  • Larsbrink J, Rogers TE, Hemsworth GR, McKee LS, Tauzin AS, Spadiut O et al (2014) A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes. Nature 506(7489):498–502

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lee YY, Derakhshan MH (2013) Environmental and lifestyle risk factors of gastric cancer. Arch Iran Med 16(6):358–365

    PubMed  Google Scholar 

  • Ley RE, Peterson DA, Gordon JI (2006) Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 124(4):837–848

    Article  CAS  PubMed  Google Scholar 

  • Ley RE, Turnbaugh PJ, Klein S, Gordon JI (2006) Microbial ecology: human gut microbes associated with obesity. Nature 444(7122):1022–1023

    Article  CAS  PubMed  Google Scholar 

  • Li KK, Tian PJ, Wang SD, Lei P, Qu L, Huang JP, Shan YJ, Li BL (2017) Targeting gut microbiota: Lactobacillus alleviated type 2 diabetes via inhibiting LPS secretion and activating GPR43 pathway. J Funct Foods 38:561–570

    Article  CAS  Google Scholar 

  • Li Z, Yang S, Lin H, Huang J, Watkins PA, Moser AB, DeSimone C, Song XY, Diehl AM (2003) Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 37(2):343–350

    Article  CAS  PubMed  Google Scholar 

  • Liu Q, Duan Z, Ha D, Bengmark S, Kurtovic J, Riordan SM (2004) Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis. Hepatology 39(5):1441–1449

    Article  PubMed  Google Scholar 

  • Liu J, Wang J, Leng Y, Lv C (2013) Intake of fruit and vegetables and risk of esophageal squamous cell carcinoma: a meta-analysis of observational studies. Int J Cancer 133(2):473–485

    Article  CAS  PubMed  Google Scholar 

  • Lloyd-Price J, Abu-Ali G, Huttenhower C (2016) The healthy human microbiome. Genome Med 8(1):1–11

    Article  Google Scholar 

  • Lofgren JL, Whary MT, Ge Z et al (2011) Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia. Gastroenterology 140(1):210–220

    Article  PubMed  Google Scholar 

  • Loo VG, Bourgault AM, Poirier L, Lamothe F, Michaud S, Turgeon N, Toye B, Beaudoin A, Frost EH, Gilca R, Brassard P (2011) Host and pathogen factors for Clostridium difficile infection and colonization. N Engl J Med 365(18):1693–1703

    Article  CAS  PubMed  Google Scholar 

  • Loprieno N (1975) International Agency for Research on Cancer (IARC) monographs on the evaluation of carcinogenic risk of chemicals to man:" relevance of data on mutagenicity". Mutat Res 31(3):210

    CAS  PubMed  Google Scholar 

  • Luo W, Fedda F, Lynch P, Tan D (2018) CDH1 gene and hereditary diffuse gastric cancer syndrome: molecular and histological alterations and implications for diagnosis and treatment. Front Pharmacol 9:1421

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ma D, Chen Y, Chen T (2019) Vaginal microbiota transplantation for the treatment of bacterial vaginosis: a conceptual analysis. FEMS Microbiol Lett 366(4):fnz025

    Article  CAS  PubMed  Google Scholar 

  • Macpherson AJ, Harris NL (2004) Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol 4(6):478–485

    Article  CAS  PubMed  Google Scholar 

  • Majewski M, Mertowska P, Mertowski S, Smolak K, Grywalska E, Torres K (2022) Microbiota and the immune system—actors in the gastric cancer story. Cancer 14(15):3832

    Article  CAS  Google Scholar 

  • Mändar R (2013) Microbiota of male genital tract: impact on the health of man and his partner. Pharmacol Res 69:32–41

    Article  PubMed  Google Scholar 

  • Marchesi JR, Adams DH, Fava F, Hermes GD, Hirschfield GM, Hold G, Quraishi MN, Kinross J, Smidt H, Tuohy KM, Thomas LV (2016) The gut microbiota and host health: a new clinical frontier. Gut 65(2):330–339

    Article  PubMed  Google Scholar 

  • McMichael AJ, Giles GG (1988) Cancer in migrants to Australia: extending the descriptive epidemiological data. Cancer Res 48(3):751–756

    CAS  PubMed  Google Scholar 

  • Minami Y, Nishino Y, Tsubono Y, Tsuji I, Hisamichi S (2006) Increase of colon and rectal cancer incidence rates in Japan: trends in incidence rates in Miyagi Prefecture, 1959-1997. J Epidemiol 16(6):240–248

    Article  PubMed  PubMed Central  Google Scholar 

  • Minoura-Etoh J, Gotoh K, Sato R, Ogata M, Kaku N, Fujioka T, Nishizono A (2006) Helicobacter pylori-associated oxidant monochloramine induces reactivation of Epstein–Barr virus (EBV) in gastric epithelial cells latently infected with EBV. J Med Microbiol 55(7):905–911

    Article  CAS  PubMed  Google Scholar 

  • Monaco CL, Gootenberg DB, Zhao G, Handley SA, Ghebremichael MS, Lim ES, Lankowski A, Baldridge MT, Wilen CB, Flagg M, Norman JM (2016) Altered virome and bacterial microbiome in human immunodeficiency virus-associated acquired immunodeficiency syndrome. Cell Host Microbe 19(3):311–322

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Morowitz MJ, Carlisle EM, AlverdyJC. (2011) Contributions of intestinal bacteria to nutrition and metabolism in the critically ill. Surg Clin North Am 91(4):771–785

    Article  PubMed  PubMed Central  Google Scholar 

  • Morris Brown L, Hoover R, Silverman D, Baris D, Hayes R, Swanson GM, Schoenberg J, Greenberg R, Liff J, Schwartz A, Dosemeci M (2001) Excess incidence of squamous cell esophageal cancer among US Black men: role of social class and other risk factors. Am J Epidemiol 153(2):114–122

    Article  Google Scholar 

  • Nardone G, Compare D (2015) The human gastric microbiota: Is it time to rethink the pathogenesis of stomach diseases? United European Gastroenterol J 3(3):255–260

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Neish AS (2009) Microbes in gastrointestinal health and disease. Gastroenterology 136(1):65–80

    Article  PubMed  Google Scholar 

  • Nelson MH, Diven MA, Huff LW, Paulos CM (2015) Harnessing the microbiome to enhance cancer immunotherapy. J Immunol Res 2015:368736

    Article  PubMed  PubMed Central  Google Scholar 

  • Neto AG, Whitaker A, Pei Z (2016) February. Microbiome and potential targets for chemoprevention of esophageal adenocarcinoma. Semin Oncol 43(1):86–96

    Article  PubMed  Google Scholar 

  • O’Keefe SJ, Kidd M, Espitalier-Noel G, Owira P (1999) Rarity of colon cancer in Africans is associated with low animal product consumption, not fiber. Am J Gastroenterol 94(5):1373–1380

    Article  PubMed  Google Scholar 

  • Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Ruth TY (2020) A universal gut-microbiome-derived signature predicts cirrhosis. Cell Metab 32(5):878–888

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Oren A, Garrity GM (2019) List of new names and new combinations previously effectively, but not validly, published. Int J Syst Evol Microbiol 69(1):5–9

    Article  PubMed  Google Scholar 

  • Pan R, Zhu M, Yu C, Lv J, Guo Y, Bian Z, Yang L, Chen Y, Hu Z, Chen Z, Li L (2017) Cancer incidence and mortality: a cohort study in China, 2008–2013. Int J Cancer 141(7):1315–1323

    Article  CAS  PubMed  Google Scholar 

  • Parbie PK, Mizutani T, Ishizaka A, Kawana-Tachikawa A, Runtuwene LR, Seki S, Abana CZY, Kushitor D, Bonney EY, Ofori SB, Uematsu S (2021) Dysbioticfecal microbiome in HIV-1 infected individuals in Ghana. Front Cell Infect Microbiol 11:646467

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Parkes GC, Rayment NB, Hudspith BN, Petrovska L, Lomer MC, Brostoff J, Whelan K, Sanderson JD (2012) Distinct microbial populations exist in the mucosa-associated microbiota of sub-groups of irritable bowel syndrome. Neurogastroenterol Motil 24(1):31–39

    Article  CAS  PubMed  Google Scholar 

  • Patel TN, Roy S, Ravi R (2017) Gastric cancer and related epigenetic alterations. Ecancermedicalscience 11:714

    Article  PubMed  PubMed Central  Google Scholar 

  • Pattison CP, Combs MJ, Marshall BJ (1997) Helicobacter pylori and peptic ulcer disease: evolution to revolution to resolution. Am J Roentgenol 168(6):1415–1420

    Article  CAS  Google Scholar 

  • Primo BDAA, Dantas CKD, Ferreira CWS (2022) Impacts of COVID-19 on physiotherapy care for women with breast cancer. Fisioter Mov 35:e35605

    Google Scholar 

  • Pushalkar S, Hundeyin M, Daley D, Zambirinis CP, Kurz E, Mishra A, Mohan N, Aykut B, Usyk M, Torres LE, Werba G (2018) The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression microbiome influences pancreatic oncogenesis. Cancer Discov 8(4):403–416

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Qiao-Li W, Shao-Hua X, Wen-Tao L, Lagergren J (2017) Smoking cessation and risk of esophageal cancer by histological type: systematic review and meta-analysis. J Natl Cancer Inst 109(12):1

    Google Scholar 

  • Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, Nielsen T, Pons N, Levenez F, Yamada T, Mende DR (2010) A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464(7285):59–65

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Quigley EM (2013) Gut bacteria in health and disease. Gastroenterol Hepatol (NY) 9:560–569

    Google Scholar 

  • Rajagopala SV, Yooseph S, Harkins DM, Moncera KJ, Zabokrtsky KB, Torralba MG, Tovchigrechko A, Highlander SK, Pieper R, Sender L, Nelson KE (2016) Gastrointestinal microbial populations can distinguish pediatric and adolescent Acute Lymphoblastic Leukemia (ALL) at the time of disease diagnosis. BMC Genomics 17(1):1–10

    Article  Google Scholar 

  • Rakoff-Nahoum S, Medzhitov R (2008) Innate immune recognition of the indigenous microbial flora. Mucosal Immunol 1(Suppl 1):S10–S14

    Article  CAS  PubMed  Google Scholar 

  • Rasmussen T, Kirkeby LP, Poulsen K, Reinholdt J, Kilian M (2000) Resident aerobic microbiota of the adult human nasal cavity. Apmis 108:663–675

    Article  CAS  PubMed  Google Scholar 

  • Ridlon JM, Bajaj JS (2015) The human gut sterolbiome: bile acid-microbiome endocrine aspects and therapeutics. Acta Pharmaceutica Sinica B 5(2):99–105

    Article  PubMed  PubMed Central  Google Scholar 

  • Roane TM, Reynolds KA, Maier RM, Pepper IL (2009) Microorganisms. Environ Microbiol:9–39

    Google Scholar 

  • Roberfroid MB, Bornet F, Bouley C, Cummings JH (1995) Colonic microflora: nutrition and health. Summary and conclusions of an International Life Sciences Institute (ILSI) [Europe] workshop held in Barcelona, Spain. Nutr Rev 53(5):127–130

    Article  CAS  PubMed  Google Scholar 

  • Round JL, Mazmanian SK (2009) The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 9(5):313–323

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rutayisire E, Huang K, Liu Y, Tao F (2016) The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants' life: a systematic review. BMC Gastroenterol 16:86

    Article  PubMed  PubMed Central  Google Scholar 

  • Sanduzzi Zamparelli M, Rocco A, Compare D, Nardone G (2017) The gut microbiota: A new potential driving force in liver cirrhosis and hepatocellular carcinoma. United European Gastroenterol J 5(7):944–953

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sartor RB (2008) Microbial influences in inflammatory bowel diseases. Gastroenterology 134(2):577–594

    Article  CAS  PubMed  Google Scholar 

  • Savage DC (1977) Microbial ecology of the gastrointestinal tract. Annu Rev Microbiol 31(1):107–133

    Article  CAS  PubMed  Google Scholar 

  • Savolainen S, Ylikoski J, Jousimies-Somer H (1986) The bacterial flora of the nasal cavity in healthy young men. Rhinology 24:249–255

    CAS  PubMed  Google Scholar 

  • Scanlan PD, Shanahan F, Clune Y, Collins JK, O’Sullivan GC, O’Riordan M et al (2008) Culture-independent analysis of the gut microbiota in colorectal cancer and polyposis. Environ Microbiol 10(3):789–798

    Article  CAS  PubMed  Google Scholar 

  • Schauber J, Svanholm C, TermĂ©n S, Iffland K, Menzel T, Scheppach W et al (2003) Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways. Gut 52(5):735–741

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schloss PD, Handelsman J (2004) Status of the microbial census. Microbiol Mol Biol Rev 68:686–691

    Article  PubMed  PubMed Central  Google Scholar 

  • Schnabl B, Brenner DA (2014) Interactions between the intestinal microbiome and liver diseases. Gastroenterology 146(6):1513–1524

    Article  CAS  PubMed  Google Scholar 

  • Sekirov I, Russell SL, Antunes LC, Finlay BB (2010) Gut microbiota in health and disease. Physiol Rev 90(3):859–904

    Article  CAS  PubMed  Google Scholar 

  • Sitarz R, Skierucha M, Mielko J, Offerhaus GJA, Maciejewski R, Polkowski WP (2018) Gastric cancer: epidemiology, prevention, classification, and treatment. Cancer Manag Res 10:239

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Soeta N, Terashima M, Gotoh M, Mori S, Nishiyama K, Ishioka K, Kaneko H, Suzutani T (2009) An improved rapid quantitative detection and identification method for a wide range of fungi. J Med Microbiol 58(8):1037–1044

    Article  CAS  PubMed  Google Scholar 

  • Sung JJ, Coker OO, Chu E, Szeto CH, Luk STY, Lau HCH, Yu J (2020) Gastric microbes associated with gastric inflammation, atrophy and intestinal metaplasia 1 year after Helicobacter pylori eradication. Gut 69(9):1572–1581

    Article  CAS  PubMed  Google Scholar 

  • Sung JJ, Lin SR, Ching JY, Zhou LY, To KF, Wang RT, Leung WK, Enders KW, Lau JY, Lee YT, Yeung CK (2000) Atrophy and intestinal metaplasia one year after cure of H. pylori infection: a prospective, randomized study. Gastroenterology 119(1):7–14

    Article  CAS  PubMed  Google Scholar 

  • Taja-Chayeb L, Vidal-Millán S, Trejo-Becerril C, PĂ©rez-Cárdenas E, Chávez-Blanco A, DomĂ­nguez-GĂłmez G, González-Fierro A, Romo-PĂ©rez A, Dueñas-González A (2022) Hereditary diffuse gastric cancer (HDGC). An overview. Clin Res Hepatol Gastroenterol 46(4):101820

    Article  CAS  PubMed  Google Scholar 

  • Taylor VM, Ko LK, Hwang JH, Sin MK, Inadomi JM (2015) Gastric cancer in asianamerican populations: a neglected health disparity. Asian Pac J Cancer Prev 15(24):10565–10571

    Article  Google Scholar 

  • Thursby E, Juge N (2017) Introduction to the human gut flora. Biochem J 474(11):1823–1836

    Article  CAS  PubMed  Google Scholar 

  • Tilg H, Moschen AR (2010) Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology 52(5):1836–1846

    Article  CAS  PubMed  Google Scholar 

  • Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A (2015) Global cancer statistics, 2012. CA Cancer J Clin 65(2):87–108

    Article  PubMed  Google Scholar 

  • Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R (2018) The gut–liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol 15(7):397–411

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tsalamandris S, Antonopoulos AS, Oikonomou E, Papamikroulis GA, Vogiatzi G, Papaioannou S, Deftereos S, Tousoulis D (2019) The role of inflammation in diabetes: current concepts and future perspectives. Eur Cardiol Rev 14(1):50

    Article  Google Scholar 

  • Ursell LK, Haiser HJ, Van Treuren W, Garg N, Reddivari L, Vanamala J et al (2014) The intestinal metabolome: an intersection between microbiota and host. Gastroenterology 146(6):1470–1476

    Article  CAS  PubMed  Google Scholar 

  • Vassallo G, Mirijello A, Ferrulli A, Antonelli M, Landolfi R, Gasbarrini A, Addolorato G (2015) alcohol and gut microbiota-the possible role of gut microbiota modulation in the treatment of alcoholic liver disease. Aliment Pharmacol Ther 41(10):917–927

    Article  CAS  PubMed  Google Scholar 

  • Verhulst SL, Vael C, Beunckens C, Nelen V, Goossens H, Desager K (2008) A longitudinal analysis on the association between antibiotic use, intestinal microflora, and wheezing during the first year of life. J Asthma 45(9):828–832

    Article  PubMed  Google Scholar 

  • Verstraelen H, Vilchez-Vargas R, Desimpel F, Jauregui R, Vankeirsbilck N, Weyers S, Verhelst R, De Sutter P, Pieper DH, Van De Wiele T (2016) Characterisation of the human uterine microbiome in non-pregnant women through deep sequencing of the V1-2 region of the 16S rRNA gene. PeerJ 4:e1602

    Article  PubMed  PubMed Central  Google Scholar 

  • Vujkovic-Cvijin I, Sortino O, Verheij E, Sklar J, Wit FW, Kootstra NA, Sellers B, Brenchley JM, Ananworanich J, Loeff MSVD, Belkaid Y (2020) HIV-associated gut dysbiosis is independent of sexual practice and correlates with noncommunicable diseases. Nat Commun 11(1):1–15

    Article  Google Scholar 

  • Wagnerberger S, Spruss A, Kanuri G, Stahl C, Schröder M, Vetter W, Bischoff SC, Bergheim I (2013) Lactobacillus casei Shirota protects from fructose-induced liver steatosis: a mouse model. J Nutr Biochem 24(3):531–538

    Article  CAS  PubMed  Google Scholar 

  • Wakabayashi R, Nakahama Y, Nguyen V, Espinoza JL (2019) The host-microbe interplay in human papillomavirus-induced carcinogenesis. Microorganisms 7(7):199

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang B, Jiang X, Cao M, Ge J, Bao Q, Tang L et al (2016) Altered fecal microbiota correlates with liver biochemistry in nonobese patients with non-alcoholic fatty liver disease. Sci Rep 6:32002

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang B, Li L (2015) Who determines the outcomes of HBV exposure? Trends Microbiol 23(6):328–329

    Article  CAS  PubMed  Google Scholar 

  • Wang QL, Xie SH, Wahlin K, Lagergren J (2018) Global time trends in the incidence of esophageal squamous cell carcinoma. Clin Epidemiol 10:717

    Article  PubMed  PubMed Central  Google Scholar 

  • Wen L, Ley RE, Volchkov PY, Stranges PB, Avanesyan L, Stonebraker AC et al (2008) Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature 455(7216):1109–1113

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Whitman WB, Coleman DC, Wiebe WJ (1998) Prokaryotes: the unseen majority. Proc Natl Acad Sci U S A 95(12):6578–6583

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wieland A, Frank DN, Harnke B, Bambha K (2015) Systematic review: microbial dysbiosis and nonalcoholic fatty liver disease. Aliment Pharmacol Ther 42(9):1051–1063

    Article  CAS  PubMed  Google Scholar 

  • Wong JM, De Souza R, Kendall CW, Emam A, Jenkins DJ (2006) Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol 40:235–243

    Article  CAS  PubMed  Google Scholar 

  • Woyke T, Rubin EM (2014) Evolution searching for new branches on the tree of life. Science 346:698–699

    Article  CAS  PubMed  Google Scholar 

  • Xie SH, Lagergren J (2016) The male predominance in esophageal adenocarcinoma. Clin Gastroenterol Hepatol 14(3):338–347

    Article  PubMed  Google Scholar 

  • Xie SH, Lagergren J (2018) Social group disparities in the incidence and prognosis of oesophageal cancer. United European Gastroenterol J 6(3):343–348

    Article  PubMed  PubMed Central  Google Scholar 

  • Xie SH, Mattsson F, Lagergren J (2017) Incidence trends in oesophageal cancer by histological type: an updated analysis in Sweden. Cancer Epidemiol 47:114–117

    Article  PubMed  Google Scholar 

  • Xie SH, Rabbani S, Petrick JL, Cook MB, Lagergren J (2017) Racial and ethnic disparities in the incidence of esophageal cancer in the United States, 1992–2013. Am J Epidemiol 186(12):1341–1351

    Article  PubMed  PubMed Central  Google Scholar 

  • Yang AM, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, Bluemel S, Hartmann P, Xu J, Koyama Y, Kisseleva T (2017) Intestinal fungi contribute to development of alcoholic liver disease. J Clin Invest 127(7):2829–2841

    Article  PubMed  PubMed Central  Google Scholar 

  • Yang MH, Rampal S, Sung J, Choi YH, Son HJ, Lee JH, Kim YH, Chang DK, Rhee PL, Kim JJ, Rhee JC (2013) The association of serum lipids with colorectal adenomas. J Am Coll Gastroenterol 108(5):833–841

    Article  CAS  Google Scholar 

  • Yang L, Ying X, Liu S, Lyu G, Xu Z, Zhang X, Li H, Li Q, Wang N, Ji J (2020) Gastric cancer: Epidemiology, risk factors and prevention strategies. Chin J Cancer Res 32(6):695

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yiannakou I, Barber LE, Li S, Adams-Campbell LL, Palmer JR, Rosenberg L, Petrick JL (2022) A prospective analysis of red and processed meat intake in relation to colorectal cancer in the Black Women's Health Study. J Nutr 152(5):1254–1262

    Article  PubMed  Google Scholar 

  • Zavros Y, Rieder G, Ferguson A, Merchant JL (2002) Gastritis and hypergastrinemia due to Acinetobacter lwoffii in mice. Infect Immun 70(5):2630–2639

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang RG, Duan GC, Fan QT, Chen SY (2016) Role of Helicobacter pylori infection in pathogenesis of gastric carcinoma. World J Gastrointest Pathophysiol 7(1):97

    Article  PubMed  PubMed Central  Google Scholar 

  • Zhu H, Yang X, Zhang C, Zhu C, Tao G, Zhao L, Tang S, Shu Z, Cai J, Dai S, Qin Q (2013) Red and processed meat intake is associated with higher gastric cancer risk: a meta-analysis of epidemiological observational studies. PloS One 8(8):e70955

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Central National Herbarium, Botanical Survey of India, Howrah, Calcutta, India

    Musadiq Husain Bhat

  2. Department of Life Sciences and Allied Health Sciences, Sant Baba Bhag Singh University, Jalandhar, Punjab, India

    Younis Ahmad Hajam &  Neelam

  3. Department of Biosciences, Himachal Pradesh University, Shimla, Himachal Pradesh, India

    Rajesh Kumar

  4. Department of Biosciences, Division Zoology, Career Point University, Hamirpur, Himachal Pradesh, India

    Diksha

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  1. Musadiq Husain Bhat
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  2. Younis Ahmad Hajam
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  3. Neelam
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  4. Rajesh Kumar
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  1. INSA Senior Scientist and Professor Emeritus, Panjab University, Chandigarh, Chandigarh, India

    R.C. Sobti

  2. Former Vice Chancellor, Central University, Haryana, India

    Ramesh Chander Kuhad

  3. Professor Emeritus, University of Delhi, New Delhi, Delhi, India

    Rup Lal

  4. Department of Microbiology, Panjab University, Chandigarh, Chandigarh, India

    Parveen Rishi

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Bhat, M.H., Hajam, Y.A., Neelam, Kumar, R., Diksha (2023). Microbial Diversity and Their Role in Human Health and Diseases. In: Sobti, R., Kuhad, R.C., Lal, R., Rishi, P. (eds) Role of Microbes in Sustainable Development. Springer, Singapore. https://doi.org/10.1007/978-981-99-3126-2_1

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