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Smartphone Interface and Wearable Biosensors for on-Site Diagnosis

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Surface Engineering and Functional Nanomaterials for Point-of-Care Analytical Devices

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Abstract

With the rapid development of next-generation manufacturing, communication, and display technologies, smartphone has been widely integrated with multifunctional modules, such as sensor chips and handheld detectors for biochemical detections. Owing to the merits of high computing speed, high-resolution image analysis, and user-friendly human-computer interface, smartphone-based point-of-care testing (POCT) devices for personalized healthcare provide an affordable and accessible way for on-site diagnosis without using sophisticated and expensive instruments. The conventional biochemical analytical instruments are always bulky, not portable, and especially expensive; therefore, further applications are rather limited. The smartphone-based sensors and electronics have been developing rapidly, playing an increasingly important part upon the challenges confronting medical service, food industry, and public safety. This chapter presents smartphone interface and wearable biosensors for on-site analysis and takes our team’s work as examples to elaborate. The sensing mechanism, design principle of smartphone-based portable and wearable sensing system, and implementation of biosensing strategies were discussed. For better insights into the important and valuable smartphone-based portable and wearable sensing devices, several examples were carefully discussed of device designing, application scenarios, analytical targets, and future applications. In the smartphone-based portable system, optical sensing, electrochemical sensing, and photoelectrochemical sensing were introduced with specific exciting and sampling circuit implementation and on-site diagnosis applications. In the smartphone-based wearable system, we summarized the representative applications of the perspiration analysis system, implantable system, ingestible system, and wound monitoring system. Due to the wide-range permeability rate of smartphone in our lives, it can be expected that smartphone interface and wearable biosensors will gradually complement and dominate the existing health management approaches.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (Grant No. 81971703) and the Zhejiang Provincial Natural Science Foundation of China (Grant No. LZ23C100001).

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Authors and Affiliations

  1. Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, P. R. China

    Guang Liu, Yanli Lu, Chen Cheng, Jie Xu & Qingjun Liu

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  1. Guang Liu
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  2. Yanli Lu
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  3. Chen Cheng
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  4. Jie Xu
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  5. Qingjun Liu
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Correspondence to Qingjun Liu .

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  1. DTU Bioengineering, Technical University of Denmark, Kongens Lyngby, Denmark

    Buddhadev Purohit

  2. School of Biochemical Engineering, Indian Institute of Technology, Varanasi, Uttar Pradesh, India

    Pranjal Chandra

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Liu, G., Lu, Y., Cheng, C., Xu, J., Liu, Q. (2023). Smartphone Interface and Wearable Biosensors for on-Site Diagnosis. In: Purohit, B., Chandra, P. (eds) Surface Engineering and Functional Nanomaterials for Point-of-Care Analytical Devices. Springer, Singapore. https://doi.org/10.1007/978-981-99-3025-8_13

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