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Pathology and Staging

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A Guide to Management of Urological Cancers

Abstract

Renal cell carcinomas (RCCs) are the seventh most common cancer in men and tenth most common cancer in women. RCC is a complex entity, and the pathologic classification of renal carcinomas has been constantly evolving since the basic classification in 1986 by Thoenes et al., although the term typing/classification was first used by Murhpy and Mostofi in 1965. Due to the explosion in recent years of molecular advances, the classification of RCCs has undergone many changes, with many new molecularly defined entities, as well as newer morphologically defined entities with prognostic implications, and redefining and renaming of previously well-known entities. Due to the vast changes in the complexities of RCCs, this chapter has tried to focus on the basic WHO (5th edition classification, 2022) classification of RCCs, with emphasis on the changes and newer entities, pathologic factors that affect prognosis in RCCs, and finally, the most important prognostic factor, the pathologic tumor stage.

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References

  1. Moch H, et al. The 2022 World Health Organization classification of tumours of the urinary system and male genital organs—part A: renal, penile, and testicular tumours. Eur Urol. 2022;82(5):458–68.

    Article  PubMed  Google Scholar 

  2. Agnihotri S, et al. Renal cell carcinoma in India demonstrates early age of onset & a late stage of presentation. Indian J Med Res. 2014;140(5):624–9.

    PubMed  PubMed Central  Google Scholar 

  3. Kabaria R, et al. Renal cell carcinoma: links and risks. Int J Nephrol Renovasc Dis. 2016;9:45–52.

    PubMed  PubMed Central  Google Scholar 

  4. Chow WH, et al. Epidemiology and risk factors for kidney cancer. Nat Rev Urol. 2010;7(5):245–57.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Neumann HP, et al. Prevalence, morphology and biology of renal cell carcinoma in von Hippel-Lindau disease compared to sporadic renal cell carcinoma. J Urol. 1998;160:1248–54.

    Article  CAS  PubMed  Google Scholar 

  6. Przybycin CG, et al. Hereditary syndromes with associated renal neoplasia: a practical guide to histologic recognition in renal tumor resection specimen. Adv Anat Pathol. 2013;20(4):245–63.

    Article  PubMed  Google Scholar 

  7. Farley MN, et al. A novel Germline mutation in BAP-1 predisposes to familial clear-cell renal cell carcinoma. Mol Cancer Res. 2013;11(9):1061–71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Glasker S, et al. Von Hippel-Lindau disease: current challenges and future prospects. Onco Targets Ther. 2020;13:5669–90.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Kennedy JM, et al. Clinical and morphologic review of 60 hereditary renal tumors from 30 hereditary renal cell carcinoma syndrome patients: lessons from a comtemporary single institution series. Med Oncol. 2019;36(9):74. https://doi.org/10.1007/s12032-019-1297-6.

    Article  CAS  PubMed  Google Scholar 

  10. Toro JR, et al. Birt-Hogg-Dube syndrome: a novel marker of kidney neoplasia. Arch Dermatol. 1999;135(10):1195–202.

    Article  CAS  PubMed  Google Scholar 

  11. Schmidt L, et al. Molecular genetics and clinical features of Birt-Hogg-Dube syndrome. Nat Genet. 1997;16(1):68–73.

    Article  CAS  PubMed  Google Scholar 

  12. Menko FH, et al. Hereditary leiomyomatosis and renal cell cancer (HLRCC): renal cancer risk, surveillance and treatment. Familial Cancer. 2014;13(4):637–44.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Abdel-Rahman MH, et al. Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma and other cancers. J Med Genet. 2011;48(12):856–9.

    Article  CAS  PubMed  Google Scholar 

  14. Yang Y, et al. Characterization of genetically defined sporadic and hereditary type 1papillary renal cell carcinoma cell lines. Genes Chromosomes Cancer. 2021;60(6):434–46.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. WHO Classification of Tumours Editorial Board. Urinary and male genital tumours, vol. 8. 5th ed. Lyon: International Agency for Research on Cancer; 2022.

    Google Scholar 

  16. Mitchell TJ, et al. Timing the landmark events in the evolution of clear cell renal cell cancer: TRACERx renal. Cell. 2018;173(3):611–623.e17.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Pitra T, et al. Chromosomal numerical aberration pattern in papillary renal cell carcinoma: review article. Ann Diagn Pathol. 2019;40:189–99.

    Article  PubMed  Google Scholar 

  18. Garje R, et al. Comprehensive review of chromophobe renal cell carcinoma. Crit Rev Oncol Hematol. 2021;160:103287.

    Article  PubMed  Google Scholar 

  19. Williamson SR. Clear cell papillary renal cell carcinoma: an update after 15 years. Pathology. 2021;53(1):109–19.

    Article  CAS  PubMed  Google Scholar 

  20. Trpkov K, et al. Eosinophilic, solid, and cystic renal cell carcinoma. Am J Surg Pathol. 2016;40(1):60–71.

    Article  PubMed  Google Scholar 

  21. Sharma R, et al. Eosinophilic solid and cystic renal cell carcinoma: from unclassified to classified, a case report. Turk Patoloji Derg. 2022;38(1):60–5.

    PubMed  PubMed Central  Google Scholar 

  22. Nathany S, Monappa V. Mucinous tubular and spindle cell carcinoma: a review of histopathology and clinical and prognostic implications. Arch Pathol Lab Med. 2020;144(1):115–8.

    Article  CAS  PubMed  Google Scholar 

  23. Seo AN, et al. Clinicopathologic and molecular pathology of collecting duct carcinoma and related renal cell carcinomas. Adv Anat Pathol. 2017;24(2):65–77.

    Article  CAS  PubMed  Google Scholar 

  24. Muller M, et al. Pattern multiplicity and fumarate hydratase (FH)/S-(2-succino)-cysteine (2SC) staining but not eosinophilic nucleoli with perinucleolar halos differentiate hereditary leiomyomatosis and renal cell carcinoma-associated renal cell carcinomas from kidney tum. Mod Pathol. 2018;31(6):974–83.

    Article  CAS  PubMed  Google Scholar 

  25. Argani P. Translocation carcinomas of the kidney. Genes Chromosom Cancer. 2022;61(5):219–27.

    Article  CAS  PubMed  Google Scholar 

  26. Kuroda N, et al. Review of succinate dehydrogenase-deficient renal cell carcinoma with focus on clinical and pathobiological aspects. Pol J Pathol. 2016;1:3–7.

    Article  Google Scholar 

  27. Cheng JX, et al. Renal medullar carcinoma:rhabdoid features and the absence of INI1 expression as markers of aggressive behaviour. Mod Pathol. 2008;21(6):647–52.

    Article  CAS  PubMed  Google Scholar 

  28. Trpkov K, et al. New developments in existing WHO entities and evolving molecular concepts: the genitourinary pathology society (GUPS) update on renal neoplasia. Mod Pathol. 2021;34(7):1392–424.

    Article  PubMed  Google Scholar 

  29. Truong LD, Shen SS. Immunohistochemical diagnosis of renal neoplasms. Arch Pathol Lab Med. 2011;135(1):92–109.

    Article  PubMed  Google Scholar 

  30. Akgul M, Williamson SR. Immunohistochemistry for the diagnosis of renal epithelial neoplasms. Semin Diagn Pathol. 2022;39(1):1–16.

    Article  PubMed  Google Scholar 

  31. Delahunt B, et al. Grading of renal cell carcinoma. Histopathology. 2019;74(1):4–17.

    Article  PubMed  Google Scholar 

  32. Dagher J, et al. Percentage grade 4 tumor predicts outcome for clear cell renal cell carcinoma. Pathology. 2019;51(4):349–52.

    Article  PubMed  Google Scholar 

  33. Samaratunga H, et al. Granular necrosis: a distinctive form of cell death in malignant tumors. Pathology. 2020;52(5):507–14.

    Article  PubMed  Google Scholar 

  34. Amin MB, et al. The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population-based to a more “personalized” approach to cancer staging. CA Cancer J Clin. 2017;67(2):93–9.

    Article  PubMed  Google Scholar 

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Correspondence to Meenakshi Rao .

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Rao, M., Thirunavukkarasu, B. (2023). Pathology and Staging. In: Singh, P., Nayak, B., Panaiyadiyan, S. (eds) A Guide to Management of Urological Cancers. Springer, Singapore. https://doi.org/10.1007/978-981-99-2341-0_2

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  • DOI: https://doi.org/10.1007/978-981-99-2341-0_2

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