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Ulcers Caused by Calciphylaxis

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Uncommon Ulcers of the Extremities

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Abstract

Calciphylaxis, also known as calcific uremic arteriolopathy (CUA), is a rare and life-threatening disorder that usually occurs in patients with end-stage renal disease (ESRD) and less frequently in non-uremic patients [1–3].

The term calciphylaxis, first coined by Dr. Seyle in 1961, literally means “protection by calcification.” Dr. Seyle described calciphylaxis in rats as an adaptive (phylatic) response that leads to calcium deposition in the affected tissues [4]. In 1963, Eisenberg and Bartholow reported a case of extensive metastatic calcification in a patient with chronic renal failure, which represented the human counterpart of calciphylaxis [5]. Over the course of the following years several cases of calciphylaxis have been described [6–10].

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Authors and Affiliations

  1. Department of Dermatology, University of Pisa, Pisa, Italy

    Alessandra Michelucci, Valentina Dini & Marco Romanelli

  2. Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA

    Paolo Romanelli

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  1. Alessandra Michelucci
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  1. Institute of Medical Sciences, Department of Surgery, Banaras Hindu University, Varanasi, India

    Ajay K. Khanna

  2. Institute of Medical Sciences, Department of General Surgery, Banaras Hindu University, Varanasi, India

    Satyendra Kumar Tiwary

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Michelucci, A., Romanelli, P., Dini, V., Romanelli, M. (2023). Ulcers Caused by Calciphylaxis. In: Khanna, A.K., Tiwary, S.K. (eds) Uncommon Ulcers of the Extremities. Springer, Singapore. https://doi.org/10.1007/978-981-99-1782-2_8

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