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Drug Induced Ulceration of Extremities

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Uncommon Ulcers of the Extremities

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Abstract

Medications are a rare and often ignored cause of limb ulcers. It is presumed that around 1.1% of chronic leg ulcers can be caused by drugs. Limb ulcers can be related to the pharmacological action of drugs or can be the manifestation of drug induced vasculitis or immunological alterations. Early suspicion of drug involvement in the induction of ulcers can result in timely intervention and can prevent considerable morbidity and mortality. Cutaneous ulcers can be observed in complicated cases of drug related immunological conditions such as Stevens-Johnson syndrome (SJS). The aim of the present chapter is to provide a comprehensive review on common drugs implicated in limb ulcers, the possible mechanisms of ulcer development, the phenotypic patterns of drug induced extremity ulcers, their management, and outcomes.

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Authors and Affiliations

  1. Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India

    Upinder Kaur

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  1. Upinder Kaur
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Editors and Affiliations

  1. Institute of Medical Sciences, Department of Surgery, Banaras Hindu University, Varanasi, India

    Ajay K. Khanna

  2. Institute of Medical Sciences, Department of General Surgery, Banaras Hindu University, Varanasi, India

    Satyendra Kumar Tiwary

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© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Kaur, U. (2023). Drug Induced Ulceration of Extremities. In: Khanna, A.K., Tiwary, S.K. (eds) Uncommon Ulcers of the Extremities. Springer, Singapore. https://doi.org/10.1007/978-981-99-1782-2_17

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  • DOI: https://doi.org/10.1007/978-981-99-1782-2_17

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-99-1781-5

  • Online ISBN: 978-981-99-1782-2

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