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A Review of mRNA Vaccines with the Aid of Lipid Nanoparticles

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Advanced Nanomaterials and Their Applications (ICANA 2022)

Part of the book series: Springer Proceedings in Materials ((SPM,volume 22))

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Abstract

This review article highlights the importance of messenger ribonucleic acid (mRNA) vaccines and how it has been developed to fight against various diseases such as, human immunodeficiency virus (HIV), rabies, cancer treatments, and coronavirus (Covid-19). During the past two years, covid-19 has become a worldwide pandemic, and the mRNA has played a major role in the manufacturing of its vaccine. We have highlighted the technology behind the development of mRNA vaccine, synthesis, and working of the lipid nanoparticles (LNPs). This mRNA vaccine produces a duplicate of a molecule that corresponds to a viral protein for producing an immune response, and these are given to us in a series of shots designed to protect us from developing a disease. The LNPs which carry the mRNA protein prevent the degradation of it and maintain more constant serum levels. In addition, this review article specifically mentions HIV, rabies, cancer, covid-19 and how these are important in the treatment of these diseases. This review article further highlights the mRNA vaccines for the survival of human beings against various deadly diseases in the near future.

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Acknowledgements

We express our sincere thanks to the Chancellor, Vice-presidents, the Management, Dean, HOD of the VIT-AP University, Andhra Pradesh for supporting a suitable International conference funding to attend, present the work in the ICANA conference and make this paper a successful one.

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Authors and Affiliations

  1. School of Electronics Engineering, VIT-AP University, Vijayawada, Andhra Pradesh, 522241, India

    Simran Saikia & Shreya Barman

  2. Department of Physics, School of Advanced Sciences, VIT-AP University, Vijayawada, Andhra Pradesh, 522241, India

    S. Sudhimon, M. Mukesh Kumar & J. Sudagar

  3. Department of Computer Science and Engineering, Chennai Institute of Technology, Chennai, Tamil Nadu, 600069, India

    G. Shanmugasundaram

Authors
  1. Simran Saikia
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  2. Shreya Barman
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  3. S. Sudhimon
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  4. M. Mukesh Kumar
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  5. G. Shanmugasundaram
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  6. J. Sudagar
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Corresponding author

Correspondence to J. Sudagar .

Editor information

Editors and Affiliations

  1. School of Advanced Sciences, VIT-AP University, Amaravati, Andhra Pradesh, India

    N. Madhusudhana Rao

  2. Department of Polymers and Functional Materials, CSIR-Indian Institute of Chemical Technology, Hyderabad, India

    Giribabu Lingamallu

  3. Department of Mechanical and Energy Engineering, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA

    Mangilal Agarwal

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© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Saikia, S., Barman, S., Sudhimon, S., Kumar, M.M., Shanmugasundaram, G., Sudagar, J. (2023). A Review of mRNA Vaccines with the Aid of Lipid Nanoparticles. In: Rao, N.M., Lingamallu, G., Agarwal, M. (eds) Advanced Nanomaterials and Their Applications. ICANA 2022. Springer Proceedings in Materials, vol 22. Springer, Singapore. https://doi.org/10.1007/978-981-99-1616-0_11

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