Abstract
In this paper, laser-induced breakdown spectroscopy (LIBS) technique is used to analyze human fingernails using nanosecond laser pulses from an neodymium-doped yttrium aluminum garnet laser (Nd:YAG) at 1064 nm. Nail as a biosample has various advantages when compared to other biological samples. Ca, Mg, Fe, and other elements found in the body can also be found in the nail, but in varying concentration. The emission spectrum from nail samples was collected in the spectral range of 180–900 nm, and it revealed the presence of elements like Mg, Zn, Fe, Mn, P, I, Na, Ca, K. Nail samples were collected from different subjects based on age, gender, and medical conditions. A total of 27 samples were collected; 17 of them were collected from normal people, and 10 of them were collected from people with different pathological conditions like diabetes, thyroid, PCOS, wheezing, etc. The results obtained in abnormal samples were analyzed and verified.
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References
Harun HA, Zainal R, Daud YM (2017) Analysing human nails composition by using laser induced breakdown spectroscopy. Sains Malaysiana 46(1):75–82
Fortes FJ, Moros J, Lucena P, Cabalín LM, Laserna JJ (2013) Laser-induced breakdown spectroscopy. Anal Chem 85(2):640–669
Kaiser J, Novotný K, Martin MZ, Hrdlička A, Malina R, Hartl M, Adam V, Kizek R (2012) Trace elemental analysis by laser-induced breakdown spectroscopy—biological applications. Surf Sci Rep 67(11–12):233–243
He K (2011) Trace elements in nails as biomarkers in clinical research. Eur J Clin Invest 41(1):98–102
Nasli-Esfahani E, Faridbod F, Larijani B, Ganjali MR, Norouzi P (2011) Trace element analysis of hair, nail, serum and urine of diabetes mellitus patients by inductively coupled plasma atomic emission spectroscopy. J Diabetes Metab Disord 10:5
Zhang S, Hu Z, Zhao Z, Chen F, Tang Y, Sheng Z, Guo L (2021) Quantitative analysis of mineral elements in hair and nails using calibration-free laser-induced breakdown spectroscopy. Optik 242:167067
Rusak DA, Zeleniak AE, Obuhosky JL, Holdren SM, Noldy CA (2013) Quantitative determination of calcium, magnesium, and zinc in fingernails by laser-induced breakdown spectroscopy. Talanta 117:55–59
Pathak AK, Kumar R, Singh VK, Agrawal R, Rai S, Rai AK (2012) Assessment of LIBS for spectrochemical analysis: a review. Appl Spectrosc Rev 47(1):14–40
Hark RR, East LJ (2014) Forensic applications of LIBS. In: Laser-induced breakdown spectroscopy. Springer, Berlin, Heidelberg, pp 377–420
Ledesma R, et al (2019) Correlation of trace silicone contamination analyses on epoxy composites using X-ray Photoelectron Spectroscopy (XPS) and Laser-Induced Breakdown Spectroscopy (LIBS). Appl Spectrosc 73(2):229–235
NIST database link. https://physics.nist.gov/PhysRefData/Handbook/Tables/findinglist.htm
Chaudhary K, Ehmann W, Rengan K, Markesbery W (1995) Trace element correlations with age and sex in human fingernails. J Radioanal Nucl Chem 195(1):51–56
Ahmed I, Ahmed R, Yang J, Law AWL, Zhang Y, Lau C (2017) Elemental analysis of the thyroid by laser induced breakdown spectroscopy. Biomed Opt Express 8:4865–4871
Bahreinian M, Tavassoli SH. Possibility of thyroidism diagnosis by laser induced breakdown spectroscopy of human fingernail
Burman KD, Wartofsky L (2000) Iodine effects on the thyroid gland: biochemical and clinical aspects. Rev Endocr Metab Disord 1(1–2):19
Bahreini M, Ashrafkhani B, Tavassoli SH (2013) Discrimination of patients with diabetes mellitus and healthy subjects based on laser-induced breakdown spectroscopy of their fingernails. J Biomed Opt 18(10):107006
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Rithika, K., Sowmya, R., kumar, G.R., Thangaraja, M., John, P., Kumar, V.S. (2023). Detection of Pathological Conditions in Nail Samples Using Laser-Induced Breakdown Spectroscopy. In: Rao, N.M., Lingamallu, G., Agarwal, M. (eds) Advanced Nanomaterials and Their Applications. ICANA 2022. Springer Proceedings in Materials, vol 22. Springer, Singapore. https://doi.org/10.1007/978-981-99-1616-0_10
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DOI: https://doi.org/10.1007/978-981-99-1616-0_10
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