Abstract
Recent studies show the peripheral origin of the disease in the central nervous system such as Parkinson’s disease, Alzheimer’s disease, ADHD, and autism. Most of the etiology is the dysfunction of the intestine. In this chapter, we show that there are several chemicals, whose target organ is the intestine, and they might be involved in these diseases.
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References
Aarts E, Ederveen THA, Naaijen J, Zwiers MP, Boekhorst J, Timmerman HM, Smeekens SP, Netea MG, Buitelaar JK, Franke B, van Hijum SAFT, Vasquez AA (2017) Gut microbiome in ADHD and its relation to neural reward anticipation. PloS One 12(9):e0183509. https://doi.org/10.1371/journal.pone.0183509
Althoff RR, Faraone SV, Rettew DC, Morley CP, Hudziak JJ (2005) Family, twin, adoption, and molecular genetic studies of juvenile bipolar disorder. Bipolar Disord 7(6):598–609. https://doi.org/10.1111/j.1399-5618.2005.00268.x
Alzheimer A (1911) Über eigenartige Krankheitsfälle des späteren Alters. Z Ges Neurol Psychiat 4:356–385
Asperger H (1944) Die ‘Autistischen Psychopathen’ im Kindesalter. Archiv für Psychiatrie und Nervenkrankheiten (in German) 117:76–136. https://doi.org/10.1007/BF01837709
Baillie-Hamilton PF (2002) Chemical toxins: a hypothesis to explain the global obesity epidemic. J Altern Complement Med 8:185–192. https://doi.org/10.1089/107555302317371479
Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P (2006) Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol 5:64–74. https://doi.org/10.1016/S1474-4422(05)70284-2
Braak H, Del Tredici K, Bratzke H, Hamm-Clement J, Sandmann-Keil D, Rub U (2002) Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson’s disease (preclinical and clinical stages). J Neurol 249(Suppl 3):III/1–III/5
Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239–259. https://doi.org/10.1007/BF00308809
Bu XL, Xiang Y, Jin J-S, Wang J, Shen L-L, Huang Z-L, Zhang K, Liu Y-H, Zeng F, Liu J-H, Sun H-L, Zhuang Z-Q, Chen S-H, Yao X-Q, Giunta B, Shan Y-C, Tan J, Chen X-W, Dong Z-F, Zhou H-D, Zhou X-F, Song W, Wang Y-J (2017) Blood-derived amyloid-βprotein induces Alzheimer’s disease pathologies. Mol Psychiatry 23:1948–1956. https://doi.org/10.1038/mp.2017.204
Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman T, B.T. (2012) Propagation of tau pathology in a model of early Alzheimer’s disease. Neuron 4:685–697
Cenit MC, Nuevo IC, Codoñer-Franch P, Dinan TG, Sanz Y (2017) Gut microbiota and ADHD: new perspectives for a challenging condition. Eur Child Adolesc Psychiatry 26:1081. https://doi.org/10.1007/s00787-017-0969-z
Chaidez V, Hansen RL, Hertz-Picciotto I (2014) Gastrointestinal problems in children with autism, developmental delays or typical development. J Autism Dev Disord 44(5):1117–1127. https://doi.org/10.1007/s10803-013-1973-x
Crespi B, Stead P, Elliot M (2010) Evolution in health and medicine Sackler colloquium: comparative genomics of autism and schizophrenia. Proc Natl Acad Sci U S A 107(Suppl 1):1736–1741. https://doi.org/10.1073/pnas.0906080106
Dinan TG, Cryan JF (2015) The impact of gut microbiota on brain and behaviour: implications for psychiatry. Curr Opin Clin Nutr Metab Care 18(6):552–558. https://doi.org/10.1097/MCO.0000000000000221
Eisele YS, Obermüller U, Heilbronner G, Baumann F, Kaeser SA, Wolburg H, Walker LC, Staufenbiel M, Heikenwalder M, Jucker M (2010) Peripherally applied Aβ-containing inoculates induce cerebral β-amyloidosis. Science 330:980–982
Faraone SV, Althoff RR, Hudziak JJ, Monuteaux MC, Biederman J (2005) The CBCL predicts DSM bipolar disorder in children: a receiver operating characteristic curve analysis. Bipolar Disord 7:518–524
Ghirardi L, Brickell I, Kuja-Halkola R, Freitag CM, Franke B, Asherson P, Lichtenstein P, Larsson H (2018) The familial co-aggregation of ASD and ADHD: a register-based cohort study. Mol Psychiatry 23(2):257–262. https://doi.org/10.1038/mp.2017.17
Goedert M, Spillantini MG, Tredici KD, Braak H (2013) 100 years of Lewy pathology. Nat Rev Neurol 9:13–24
Grün F, Blumberg B (2009) Endocrine disrupters as obesogens. Mol Cell Endocrinol 304:19–29. https://doi.org/10.1016/j.mce.2009.02.018
Hachiya NS, Sakasegawa Y, Kaneko K (2003) Unfolding chaperone as a prion protein relating molecule. Rinsho Shinkeigaku 43:817–819
Harach T, Marungruang N, Duthilleul N, Cheatham V, McCoy KD, Frisoni G, Neher JJ, Fåk F, Jucker M, Lasser T, Bolmont T (2017) Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota. Sci Rep 7:41802. https://doi.org/10.1038/srep41802
Hassler R (1937) Zur Normalanatomie der Substantia nigra. Versuch einer architektonischen Gliederung. J Psychol Neurol 48:1–55
Heikkila RE, Hess A, Duvoisin RC (1984) Dopaminergic neurotoxicity of 1-Methyl-4-Phenyl-1,2,5,6-tetrahydropyridine in mice. Science 224:1451–1453
Heindel JJ, Vom Saal FS, Blumberg B, Bovolin P, Calamandrei G, Ceresini G, Cohn BA, Fabbri E, Gioiosa L, Kassotis C, Legler JL, Merrill ML, Rizzir L, Machtinger R, Mantovani A, Mendez MA, Montanini L, Molteni L, Nagel SC, Parmigiani S, Panzica G, Paterlini S, Pomatto V, Ruzzin J, Sartor G, Schug TT, Street ME, Suvorov A, Volpi R, Zoeller RT, Palanza P (2015) Parma consensus statement on metabolic disruptors. Environ Health 14:54. https://doi.org/10.1186/s12940-015-0042-7
Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, Patterson PH, Mazmanian SK (2013) Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 155:1451–1463. https://doi.org/10.1016/j.cell.2013.11.024
Huang Z, Prusiner SB, Cohen FE (1995) Scrapie prions: a three-dimensional model of an infectious fragment. Fold Des 1:13–19
Ihara Y (2004) Alzheimer’s disease is here to know that. KUBA_PRO Inc. Tokyo (in Japanese)
Jan A, Gonçalves NP, Vaegter CB, Jensen PH, Ferreira N (2021) The prion-like spreading of alpha-synuclein in Parkinson’s disease: update on models and hypotheses. Int J Mol Sci 22(15):8338. https://doi.org/10.3390/ijms22158338
Kang D-W, Adams JB, Vargason T, Santiago M, Hahn J, Krajmalnik-Brown R (2020) Distinct fecal and plasma metabolites in children with autism spectrum disorders and their modulation after microbiota transfer therapy. mSphere 5:e00314–e00320. https://doi.org/10.1128/mSphere.00314-20
Kanner L (1943) Autistic disturbances of affective contact. Nerv Child 2:217–250
Kilian J, Kitazawa M (2018) The emerging risk of exposure to air pollution on cognitive decline and Alzheimer’s disease—evidence from epidemiological and animal studies. Biom J 41:141–162. https://doi.org/10.1016/j.bj.2018.06.001
Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, Shimizu Y (1998) Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392:605–608
Kosaka K, Oyanagi S, Matsushita M, Hori A (1976) Presenile dentia with Alzheimer-, Pick- and Lewy-body changes. Acta Neuropathol 36:221–233
Lewy FH (1912) Paralysis agitans. In: I. Pathologische Anatomie. Lewandowsky’s Handbuch der Neurologie, 3. Band: Spez. Neurologie II. Springer, Berlin, pp 920–933
Lichtenstein P, Carlström E, Råstam M, Gillberg C, Anckarsäter H (2010) The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood. Am J Psychiatry 167:1357–1363. https://doi.org/10.1176/appi.ajp.2010.10020223
Liu L, Drouet V, Wu JW, Witter MP, Small SA, Clelland C, Duff K (2012) Trans-synaptic spread of tau pathology in vivo. PloS One 7:e31302. https://doi.org/10.1371/journal.pone.0031302
Lu F-P, Lin K-P, Kuo H-K (2009) Diabetes and the risk of multi-system aging phenotypes: a systematic review and meta-analysis. PloS One 4:e4144. https://doi.org/10.1371/journal.pone.0004144
Ma C, Hong F, Yang S (2022) (2022) amyloidosis in Alzheimer’s disease: pathogeny, etiology, and related therapeutic directions. Molecules 27(4):1210. https://doi.org/10.3390/molecules27041210
Martin J et al (2014) Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants. J Am Acad Child Adolesc Psychiatry 53:761–770
Masters CL, Bateman R, Blennow K, Rowe CC, Aperling RA, Cummings JL (2015) Alzheimer’s disease. Nat Rev Dis Primers 1:15056. https://doi.org/10.1038/nrdp.2015.56
Oota M (2000) Children with ADHD—for proper understanding and proper response to ADHD. Otsukishoten, Tokyo
Pan-Montojo FJ, Funk RHW (2010) Oral administration of Rotenone using a gavage and image analysis of alpha-synuclein inclusions in the enteric nervous system. J Vis Exp 44:2123
Parkinson J (1817) An essay on the shaking palsy. J Neuropsychiatry Clin Neurosci 14:223
Pauly T, Bolakhrif N, Kaiser J, Nagel-Steger L, Gremer L, Gohlke H, Gohlke D (2022) Met/Val129 polymorphism of the full-length human prion protein dictates distinct pathways of amyloid formation. J Biol Chem 298:102430
Pfreiffer RF (2003) Gastrointestinal dysfunction in Parkinson’s disease. Lancet Neurol 2:107–116. https://doi.org/10.1016/S1474-4422(03)00307-7
Rommelse NN, Franke B, Geurts HM, Hartman CA, Buitelaar JK (2010) Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder. Eur Child Adolesc Psychiatry 19:281–295. https://doi.org/10.1007/s00787-010-0092-x
Ronald A, Simonoff E, Kuntsi J, Asherson P, Plomin R (2008) Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample. J Child Psychol Psychiatry 49:535–542. https://doi.org/10.1111/j.1469-7610.2007.01857.x
Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, Challis C, Schretter CE, Rocha S, Gradinaru V, Chesselet M-F, Keshavarzian A, Shannon KM, Krajmalnik-Brown R, Wittung-Stafshede P, Knight R, Mazmanian SK (2016) Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson’s disease. Cell 167:1469–1480.e12. https://doi.org/10.1016/j.cell.2016.11.018
Sasajima H, Miyazono S, Noguchi T, Kashiwayanagi M (2017) Intranasal administration of Rotenone to mice induces dopaminergic neurite degeneration of dopaminergic neurons in the substantia nigra. Biol Pharm Bull 40:108–112. https://doi.org/10.1248/bpb.b16-00654
Sullivan PF, Daly MJ, O'Donovan M (2012) Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nat Rev Genet 13(8):537–551. https://doi.org/10.1038/nrg3240
Takashima A (2017) Relationship between dementia and Tau protein. J Saitama Med Univ 43:134–141
Tretiakoff MC (1919) Contribution a L’étude de L’anatomie Pathologique de Locus Niger de Soemmerling. Université de Paris, Paris
Von Economo C (1931) Encephalitis lethargica: its sequelae and treatment, Translated by Newman KO. Oxford University Press, London
Yegambaram M, Manivannan B, Beach TG, Halden RU (2015) Role of environmental contaminants in the etiology of Alzheimer’s disease: a review. Curr Alzheimer Res 12:116–146
Zhao H, Nyholt DR (2017) Gene-based analyses reveal novel genetic overlap and allelic heterogeneity across five major psychiatric disorders. Hum Genet 136:263–274. https://doi.org/10.1007/s00439-016-1755-6
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Ishido, M. (2023). Toward a Dimension-Free, Pre-Emptive, Integrated Health Risk Assessment of Chemicals. In: Health Risk Assessment of Environmental Chemicals. Springer, Singapore. https://doi.org/10.1007/978-981-99-1560-6_13
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DOI: https://doi.org/10.1007/978-981-99-1560-6_13
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