Abstract
In the previous chapter, we can demonstrate rat hyperactivity through endocrine disruptors. In this chapter, it is shown that rat hyperactivity is caused by not only endocrine disruptors but also pesticides, nanoparticles, carcinogenic chemicals, and air pollutants. These suggest that rat hyperactivity is related to neither chemical structure nor exposure routes. There may be a common sensor in dopaminergic systems to integrate various branch toxicity. One potential measure is the introduction of the organ developmental stage as the time axis in the health risk assessment of chemicals, and another is the introduction of a broad framework of health risk assessment using the susceptibility of dopaminergic neurons to chemicals.
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Ishido, M. (2023). Integration of Health Risk Assessment for Various Chemicals: Common Biomarkers in Different Exposure Routes. In: Health Risk Assessment of Environmental Chemicals. Springer, Singapore. https://doi.org/10.1007/978-981-99-1560-6_12
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