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Exploring the Pathoprofiles of SARS-COV-2 Infected Human Gut–Lungs Microbiome Crosstalks

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Probiotics, Prebiotics, Synbiotics, and Postbiotics

Abstract

There has been an unprecedented scientific exploration of post-COVID-19 symptoms of the recovered patients put up with the novel coronavirus (nCoV), also called as SARS-CoV-2 infection. There have been reports of breathing difficulty, weakness, and gastrointestinal diarrhea, post SARS-CoV-2 infection recovery. Surprisingly, the thoracic computed tomography scan of the lungs and sonography of the whole abdomen appear normal in such patients. The microbiome of the body consists of all the microbes viz. bacteria, viruses, fungi, etc. and its dysbiosis often leads to depletion in immunity. Diverse microbial communities maintain the micro-ecosystem of the gut and lungs. Therefore, it has been considered of interest to assess the studies on the effect of COVID-19 on the microbiota of the lungs and gut to ascertain its link with the escalation of post-infection symptoms and to explore the pathoprofiles of gut–lungs microbiome crosstalk due to novel coronavirus which negatively affects the host immunity. Although repurposing of several drugs has been carried out to tackle the COVID-19 disease, ever since its outbreak, there has been no evidence regarding the efficacy of any specific chemotherapeutic against the novel viral-induced host gut–lungs microbiome crosstalks.

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Nandi, S., Ahmed, S., Saxena, A., Saxena, A.K. (2023). Exploring the Pathoprofiles of SARS-COV-2 Infected Human Gut–Lungs Microbiome Crosstalks. In: Kothari, V., Kumar, P., Ray, S. (eds) Probiotics, Prebiotics, Synbiotics, and Postbiotics. Springer, Singapore. https://doi.org/10.1007/978-981-99-1463-0_12

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