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Animal Models for Hepatitis E Virus

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Hepatitis E Virus

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1417))

Abstract

Animal models are one of the most important tools in the study of human hepatitis E virus (HEV) infection. They are particularly important in light of the major limitations of the cell culture system for HEV. Besides nonhuman primates, which are extremely valuable because of their susceptibility to HEV genotypes 1–4, animals like swine, rabbit, and humanized mice are also potential models for studies of pathogenesis, cross-species infection, and the molecular biology of HEV. Identification of a useful animal model for human HEV infection studies is crucial to further investigations into this ubiquitous yet poorly understood virus and facilitate the development of antiviral therapeutics and vaccines.

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Abbreviations

ALT:

Alanine aminotransferase

AST:

Aspartate aminotransferase

CNS:

Central nervous system

ET-NANB:

Enterically transmitted non-A, non-B

GE:

Genome equivalents

HEV:

Hepatitis E virus

IEM:

Immune electron microscopy

IHC:

Immunohistochemistry

IFN-γ:

Interferon-γ

i.v.:

Intravenous

PR:

Pregnant rabbit

rHEV:

Rabbit HEV

sHEV:

Swine HEV

SPF:

Specific pathogen free

uPA-SCID:

Immune-deficient urokinase-type plasminogen activator-severe combined immune deficiency

SOF:

Sofosbuvir

NOD-like receptor:

Nucleotide-binding oligomerization domain-like receptor

TNF-α:

Tumor necrosis factor-α

USB:

uPA-SCID-beige

VLP:

Virus-like particle

wpi:

Week post-inoculation

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  1. Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China

    Tianxu Liu, Lin Wang & Ling Wang

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  2. Lin Wang
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  1. Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Kunming, China

    Youchun Wang

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Liu, T., Wang, L., Wang, L. (2023). Animal Models for Hepatitis E Virus. In: Wang, Y. (eds) Hepatitis E Virus. Advances in Experimental Medicine and Biology, vol 1417. Springer, Singapore. https://doi.org/10.1007/978-981-99-1304-6_12

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