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Morphogenesis of Hepatitis E Virus

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Hepatitis E Virus

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1417))

Abstract

Hepatitis E virus, a leading cause of acute hepatitis worldwide, has been recognized as non-enveloped virus since its discovery in the 1980s. However, the recent identification of lipid membrane-associated form termed as “quasi-enveloped” HEV has changed this long-held notion. Both naked HEV and quasi-enveloped HEV play important roles in the pathogenesis of hepatitis E. However, the biogenesis and the mechanisms underlying the composition, biogenesis regulation, and functions of the novel quasi-enveloped virions remain enigmatic. In this chapter, we highlight the most recent discoveries on the dual life cycle of these two different types of virions, and further discuss the implication of the quasi-envelopment in our understanding of the molecular biology of HEV.

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Abbreviations

ASGR:

Asialoglycoprotein receptor

ATP5B:

ATP synthase subunit β

eHEV:

Quasi-enveloped hepatitis E virus

ESCRT:

Endosomal sorting complex required for transport

ET-NANB:

Enterically transmitted non-A, non-B

HAV:

Hepatitis A virus

HEV:

Hepatitis E virus

HRS:

Hepatocyte growth factor-regulated tyrosine kinase substrate

HSC70:

Heat shock cognate protein 70

HSPGs:

Heparin sulfate proteoglycan

LAL:

Lysosomal acid lipase

MVB:

Multivesicular bodies

NPC1:

Niemann–Pick disease, type C1

PtdSer:

Phosphatidylserine

RBD:

Receptor binding domain

TGOLN2:

Trans-Golgi network protein 2

TSG101:

Tumor susceptibility gene 101

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Author information

Author notes

  1. Xing Liu and Shuhui Qi contributed equally with all other contributors.

Authors and Affiliations

  1. State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

    Xing Liu, Shuhui Qi & Xin Yin

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  1. Xing Liu
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  2. Shuhui Qi
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  3. Xin Yin
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Corresponding author

Correspondence to Xin Yin .

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Editors and Affiliations

  1. Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Kunming, China

    Youchun Wang

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© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Liu, X., Qi, S., Yin, X. (2023). Morphogenesis of Hepatitis E Virus. In: Wang, Y. (eds) Hepatitis E Virus. Advances in Experimental Medicine and Biology, vol 1417. Springer, Singapore. https://doi.org/10.1007/978-981-99-1304-6_11

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