Abstract
Bacterial surface molecules such as flagella, polysaccharides, proteins like C-terminal anchored proteins, surface glycolytic enzymes, and lipoproteins aid the organism’s survival in hostile environments and can also be used as a biomarker for diagnosing infectious diseases caused by pathogens. Thus, recognition of molecular biomarkers found on bacterial cell surfaces becomes fundamental in disease recognition and further treatment. Therefore, an appropriate microbe-specific biomarker corresponding to the disease (microbial biomarker) or different types of biomarkers existing at detectable levels at various stages of the disease are crucial for the successful treatment of many infectious diseases. Biosensors have become critical components of point-of-care devices in recent years because they are directly responsible for the bioanalytical performance and are required for personalised healthcare management due to their ability to estimate the levels of biological markers. In addition, the early detection of a pathogen or a secreted microbial biomarker helps in limiting the damage caused by the pathogen or the host immune response. This chapter’s aim is to highlight the importance of these surface markers as diagnostic tools for diseases caused by various pathogenic bacteria.
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Kumari, A., Kumari, S., Kumar, P.A. (2023). The Surface Biomarkers Present on the Bacterial Cell Surface. In: Acharya, A., Singhal, N.K. (eds) Nanosensors for Point-of-Care Diagnostics of Pathogenic Bacteria. Springer, Singapore. https://doi.org/10.1007/978-981-99-1218-6_1
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