Skip to main content

Nutritional Support for Gastrointestinal Cancer Patients. III-2. Food and Nutritional Treatment

  • Chapter
  • First Online:
Gastrointestinal Cancer
  • 391 Accesses

Abstract

Food and nutrition have long been identified as possibly important determinants of cancer risk. Several studies demonstrate significant associations between dietary habits and cancer risk [1, 2]. According to the 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR), various dietary habits are recommended for cancer prevention [3]. The main points of the recommendations on food and nutrition are: (1) eat foods rich in wholegrains, vegetables, fruits, and beans; (2) limit consumption of fast food and other processed foods high in sugars, starches, or fat; (3) limit consumption of red and processed meat; (4) limit consumption of sugar sweetened drinks; (5) limit alcohol consumption. Gastrointestinal cancer (including esophageal cancer, stomach cancer, colorectal cancer, and pancreatic biliary cancer) is an important disease with an incidence and mortality of more than one-fourth of all cancers worldwide [4]. The digestive system is the boundary to which food is directly exposed, and therefore it is considered to be more affected by the risk of cancer according to the dietary habit. In this chapter, we will look at the food and nutrition that affect each gastrointestinal cancer.

Su Young Kim is the lead author of this chapter.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Lippman SM, Hawk ET. Cancer prevention: from 1727 to milestones of the past 100 years. Cancer Res. 2009;69:5269–84.

    Article  CAS  PubMed  Google Scholar 

  2. Norat T, Scoccianti C, Boutron-Ruault MC, Anderson A, Berrino F, Cecchini M, et al. European code against cancer 4th edition: diet and cancer. Cancer Epidemiol. 2015;39(Suppl 1):S56–66.

    Article  PubMed  Google Scholar 

  3. Malcomson FC, Willis ND, McCallum I, Xie L, Kelly S, Bradburn DM, et al. Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and WNT-pathway-related markers of bowel cancer risk. Br J Nutr. 2019;122:509–17.

    Article  CAS  PubMed  Google Scholar 

  4. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424.

    Article  PubMed  Google Scholar 

  5. Zhang XF, Wang XK, Tang YJ, Guan XX, Guo Y, Fan JM, et al. Association of whole grains intake and the risk of digestive tract cancer: a systematic review and meta-analysis. Nutr J. 2020;19:52.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Sun L, Zhang Z, Xu J, Xu G, Liu X. Dietary fiber intake reduces risk for Barrett’s esophagus and esophageal cancer. Crit Rev Food Sci Nutr. 2017;57:2749–57.

    Article  CAS  PubMed  Google Scholar 

  7. Tullio V, Gasperi V, Catani MV, Savini I. The impact of whole grain intake on gastrointestinal tumors: a focus on colorectal, gastric, and esophageal cancers. Nutrients. 2020;13:81.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Kubo A, Block G, Quesenberry CP Jr, Buffler P, Corley DA. Effects of dietary fiber, fats, and meat intakes on the risk of Barrett’s esophagus. Nutr Cancer. 2009;61:607–16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Liu J, Wang J, Leng Y, Lv C. Intake of fruit and vegetables and risk of esophageal squamous cell carcinoma: a meta-analysis of observational studies. Int J Cancer. 2013;133:473–85.

    Article  CAS  PubMed  Google Scholar 

  10. Papadimitriou N, Markozannes G, Kanellopoulou A, Critselis E, Alhardan S, Karafousia V, et al. An umbrella review of the evidence associating diet and cancer risk at 11 anatomical sites. Nat Commun. 2021;12:4579.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Andrici J, Eslick GD. Hot food and beverage consumption and the risk of esophageal cancer: a meta-analysis. Am J Prev Med. 2015;49:952–60.

    Article  PubMed  Google Scholar 

  12. Kim HJ, Lim SY, Lee JS, Park S, Shin A, Choi BY, et al. Fresh and pickled vegetable consumption and gastric cancer in Japanese and Korean populations: a meta-analysis of observational studies. Cancer Sci. 2010;101:508–16.

    Article  CAS  PubMed  Google Scholar 

  13. Zhou Y, Zhuang W, Hu W, Liu GJ, Wu TX, Wu XT. Consumption of large amounts of allium vegetables reduces risk for gastric cancer in a meta-analysis. Gastroenterology. 2011;141:80–9.

    Article  CAS  PubMed  Google Scholar 

  14. Wang Q, Chen Y, Wang X, Gong G, Li G, Li C. Consumption of fruit, but not vegetables, may reduce risk of gastric cancer: results from a meta-analysis of cohort studies. Eur J Cancer. 2014;50:1498–509.

    Article  PubMed  Google Scholar 

  15. Block E. The chemistry of garlic and onions. Sci Am. 1985;252:114–9.

    Article  CAS  PubMed  Google Scholar 

  16. Guo Y, Li ZX, Zhang JY, Ma JL, Zhang L, Zhang Y, et al. Association between lifestyle factors, vitamin and garlic supplementation, and gastric cancer outcomes: a secondary analysis of a randomized clinical trial. JAMA Netw Open. 2020;3:e206628.

    Article  PubMed  PubMed Central  Google Scholar 

  17. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr. 2012;31:489–98.

    Article  PubMed  Google Scholar 

  18. Ocvirk S, Wilson AS, Appolonia CN, Thomas TK, O'Keefe SJD. Fiber, fat, and colorectal cancer: new insight into modifiable dietary risk factors. Curr Gastroenterol Rep. 2019;21:62.

    Article  PubMed  Google Scholar 

  19. Desai MS, Seekatz AM, Koropatkin NM, Kamada N, Hickey CA, Wolter M, et al. A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility. Cell. 2016;167:1339–53.e21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Aune D, Chan DS, Lau R, Vieira R, Greenwood DC, Kampman E, et al. Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies. BMJ. 2011;343:d6617.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Song M, Wu K, Meyerhardt JA, Ogino S, Wang M, Fuchs CS, et al. Fiber intake and survival after colorectal cancer diagnosis. JAMA Oncol. 2018;4:71–9.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Norat T, Riboli E. Dairy products and colorectal cancer. A review of possible mechanisms and epidemiological evidence. Eur J Clin Nutr. 2003;57:1–17.

    Article  CAS  PubMed  Google Scholar 

  23. Feldman D, Krishnan AV, Swami S, Giovannucci E, Feldman BJ. The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer. 2014;14:342–57.

    Article  CAS  PubMed  Google Scholar 

  24. Aune D, Lau R, Chan DSM, Vieira R, Greenwood DC, Kampman E, et al. Dairy products and colorectal cancer risk: a systematic review and meta-analysis of cohort studies. Ann Oncol. 2012;23:37–45.

    Article  CAS  PubMed  Google Scholar 

  25. Zhang S, Jia Z, Yan Z, Yang J. Consumption of fruits and vegetables and risk of renal cell carcinoma: a meta-analysis of observational studies. Oncotarget. 2017;8:27892–903.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Aune D, Lau R, Chan DS, Vieira R, Greenwood DC, Kampman E, et al. Nonlinear reduction in risk for colorectal cancer by fruit and vegetable intake based on meta-analysis of prospective studies. Gastroenterology. 2011;141:106–18.

    Article  PubMed  Google Scholar 

  27. Song M, Chan AT. The potential role of exercise and nutrition in harnessing the immune system to improve colorectal cancer survival. Gastroenterology. 2018;155:596–600.

    Article  PubMed  Google Scholar 

  28. Aglago EK, Huybrechts I, Murphy N, Casagrande C, Nicolas G, Pischon T, et al. Consumption of fish and long-chain n-3 polyunsaturated fatty acids is associated with reduced risk of colorectal cancer in a large European cohort. Clin Gastroenterol Hepatol. 2020;18:654–66.e6.

    Article  CAS  PubMed  Google Scholar 

  29. Song M, Zhang X, Meyerhardt JA, Giovannucci EL, Ogino S, Fuchs CS, et al. Marine omega-3 polyunsaturated fatty acid intake and survival after colorectal cancer diagnosis. Gut. 2017;66:1790–6.

    Article  CAS  PubMed  Google Scholar 

  30. Vingeliene S, Chan DSM, Vieira AR, Polemiti E, Stevens C, Abar L, et al. An update of the WCRF/AICR systematic literature review and meta-analysis on dietary and anthropometric factors and esophageal cancer risk. Ann Oncol. 2017;28:2409–19.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Chapelle N, Martel M, Toes-Zoutendijk E, Barkun AN, Bardou M. Recent advances in clinical practice: colorectal cancer chemoprevention in the average-risk population. Gut. 2020;69:2244–55.

    Article  CAS  PubMed  Google Scholar 

  32. Bouvard V, Loomis D, Guyton KZ, Grosse Y, Ghissassi FE, Benbrahim-Tallaa L, et al. Carcinogenicity of consumption of red and processed meat. Lancet Oncol. 2015;16:1599–600.

    Article  PubMed  Google Scholar 

  33. Ferrucci LM, Sinha R, Huang WY, Berndt SI, Katki HA, Schoen RE, et al. Meat consumption and the risk of incident distal colon and rectal adenoma. Br J Cancer. 2012;106:608–16.

    Article  CAS  PubMed  Google Scholar 

  34. Carr PR, Walter V, Brenner H, Hoffmeister M. Meat subtypes and their association with colorectal cancer: systematic review and meta-analysis. Int J Cancer. 2016;138:293–302.

    Article  CAS  PubMed  Google Scholar 

  35. Chan DS, Lau R, Aune D, Vieira R, Greenwood DC, Kampman E, et al. Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies. PLoS One. 2011;6:e20456.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Lei Q, Zheng H, Bi J, Wang X, Jiang T, Gao X, et al. Whole grain intake reduces pancreatic cancer risk: a meta-analysis of observational studies. Medicine (Baltimore). 2016;95:e2747.

    Article  CAS  PubMed  Google Scholar 

  37. Schacht SR, Olsen A, Dragsted LO, Overvad K, Tjonneland A, Kyro C. Whole-grain intake and pancreatic cancer risk-the Danish, diet, cancer and health cohort. J Nutr. 2021;151:666–74.

    Article  PubMed  Google Scholar 

  38. Nkondjock A, Ghadirian P, Johnson KC, Krewski D, Canadian Cancer Registries Epidemiology Research Group. Dietary intake of lycopene is associated with reduced pancreatic cancer risk. J Nutr. 2005;135:592–7.

    Article  CAS  PubMed  Google Scholar 

  39. Lucas AL, Bravi F, Boffetta P, Polesel J, Serraino D, La Vecchia C, et al. Adherence to World Cancer Research Fund/American Institute for Cancer Research recommendations and pancreatic cancer risk. Cancer Epidemiol. 2016;40:15–21.

    Article  PubMed  Google Scholar 

  40. Aune D, Chan DSM, Vieira AR, Navarro Rosenblatt DA, Vieira R, Greenwood DC, et al. Dietary fructose, carbohydrates, glycemic indices and pancreatic cancer risk: a systematic review and meta-analysis of cohort studies. Ann Oncol. 2012;23:2536–46.

    Article  CAS  PubMed  Google Scholar 

  41. Rim HJ. Clonorchiasis: an update. J Helminthol. 2005;79:269–81.

    Article  PubMed  Google Scholar 

  42. Qian MB, Utzinger J, Keiser J, Zhou XN. Clonorchiasis. Lancet. 2016;387:800–10.

    Article  PubMed  Google Scholar 

  43. Kim TS, Pak JH, Kim JB, Bahk YY. Clonorchis sinensis, an oriental liver fluke, as a human biological agent of cholangiocarcinoma: a brief review. BMB Rep. 2016;49:590–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Chun, H.J., Park, S.J., Lim, Y.J., Song, S.Y. (2023). Nutritional Support for Gastrointestinal Cancer Patients. III-2. Food and Nutritional Treatment. In: Gastrointestinal Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-99-0815-8_73

Download citation

  • DOI: https://doi.org/10.1007/978-981-99-0815-8_73

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-99-0814-1

  • Online ISBN: 978-981-99-0815-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics