Skip to main content

The Use of 3D In Vitro Systems to Model Human Malaria

  • Chapter
  • First Online:
Emergence of In Vitro 3D Systems to Model Human Malaria
  • 71 Accesses

Abstract

This chapter contains a discussion on the potential use of liver organoid to understand biological complexity of cellular and molecular mechanisms involved in Plasmodium development in the liver. It also provides toolboxes for investigating parasite deployment in the 3D models.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Arez F, Rebelo SP, Fontinha D, Simao D, Martins TR, Machado M, Fischli C, Oeuvray C, Badolo L, Carrondo MJT, Rottmann M, Spangenberg T, Brito C, Greco B, Prudencio M, Alves PM (2019) Flexible 3D cell-based platforms for the discovery and profiling of novel drugs targeting Plasmodium hepatic infection. ACS Infect Dis 5:1831–1842. https://doi.org/10.1021/acsinfecdis.9b00144

    Article  CAS  PubMed  Google Scholar 

  • Bunnik EM, Venkat A, Shao J, McGovern KE, Batugedara G, Worth D, Prudhomme J, Lapp SA, Andolina C, Ross LS, Lawres L, Brady D, Sinnis P, Nosten F, Fidock DA, Wilson EH, Tewari R, Galinski MR, Ben Mamoun C, Ay F, Le Roch KG (2019) Comparative 3D genome organization in apicomplexan parasites. Proc Natl Acad Sci U S A 116:3183–3192. https://doi.org/10.1073/pnas.1810815116

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chua ACY, Ananthanarayanan A, Ong JJY, Wong JY, Yip A, Singh NH, Qu Y, Dembele L, McMillian M, Ubalee R, Davidson S, Tungtaeng A, Imerbsin R, Gupta K, Andolina C, Lee F, SWT K, Nosten F, Russell B, Lange A, Diagana TT, Renia L, BKS Y, Yu H, Bifani P (2019) Hepatic spheroids used as an in vitro model to study malaria relapse. Biomaterials 216:119221. https://doi.org/10.1016/j.biomaterials.2019.05.032

    Article  CAS  PubMed  Google Scholar 

  • Dana J, Debray D, Beaufrere A, Hillaire S, Fabre M, Reinhold C, Baumert TF, Berteloot L, Vilgrain V (2022) Cystic fibrosis-related liver disease: clinical presentations, diagnostic and monitoring approaches in the era of CFTR modulator therapies. J Hepatol 76:420–434. https://doi.org/10.1016/j.jhep.2021.09.042

    Article  CAS  PubMed  Google Scholar 

  • Dana J, Girard M, Debray D (2020) Hepatic manifestations of cystic fibrosis. Curr Opin Gastroenterol 36:192–198. https://doi.org/10.1097/MOG.0000000000000624

    Article  CAS  PubMed  Google Scholar 

  • DesRochers TM, Kimmerling EP, Jandhyala DM, El-Jouni W, Zhou J, Thorpe CM, Leong JM, Kaplan DL (2015) Effects of Shiga toxin type 2 on a bioengineered three-dimensional model of human renal tissue. Infect Immun 83:28–38. https://doi.org/10.1128/IAI.02143-14

    Article  CAS  PubMed  Google Scholar 

  • DesRochers TM, Suter L, Roth A, Kaplan DL (2013) Bioengineered 3D human kidney tissue, a platform for the determination of nephrotoxicity. PLoS One 8:e59219. https://doi.org/10.1371/journal.pone.0059219

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Epstein JE, Tewari K, Lyke KE, Sim BK, Billingsley PF, Laurens MB, Gunasekera A, Chakravarty S, James ER, Sedegah M, Richman A, Velmurugan S, Reyes S, Li M, Tucker K, Ahumada A, Ruben AJ, Li T, Stafford R, Eappen AG, Tamminga C, Bennett JW, Ockenhouse CF, Murphy JR, Komisar J, Thomas N, Loyevsky M, Birkett A, Plowe CV, Loucq C, Edelman R, Richie TL, Seder RA, Hoffman SL (2011) Live attenuated malaria vaccine designed to protect through hepatic CD8(+) T cell immunity. Science 334:475–480. https://doi.org/10.1126/science.1211548

    Article  CAS  PubMed  Google Scholar 

  • Golden-Mason L, Palmer B, Klarquist J, Mengshol JA, Castelblanco N, Rosen HR (2007) Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction. J Virol 81:9249–9258. https://doi.org/10.1128/JVI.00409-07

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hoo R, Zhu L, Amaladoss A, Mok S, Natalang O, Lapp SA, Hu G, Liew K, Galinski MR, Bozdech Z, Preiser PR (2016) Integrated analysis of the Plasmodium species transcriptome. EBioMedicine 7:255–266. https://doi.org/10.1016/j.ebiom.2016.04.011

    Article  PubMed  PubMed Central  Google Scholar 

  • Karnasuta C, Pavanand K, Chantakulkij S, Luttiwongsakorn N, Rassamesoraj M, Laohathai K, Webster HK, Watt G (1995) Complete development of the liver stage of Plasmodium falciparum in a human hepatoma cell line. Am J Trop Med Hyg 53:607–611. https://doi.org/10.4269/ajtmh.1995.53.607

    Article  CAS  PubMed  Google Scholar 

  • Kasprowicz V, Schulze Zur Wiesch J, Kuntzen T, Nolan BE, Longworth S, Berical A, Blum J, McMahon C, Reyor LL, Elias N, Kwok WW, McGovern BG, Freeman G, Chung RT, Klenerman P, Lewis-Ximenez L, Walker BD, Allen TM, Kim AY, Lauer GM (2008) High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. J Virol 82:3154–3160. https://doi.org/10.1128/JVI.02474-07

    Article  CAS  PubMed  Google Scholar 

  • Kroy DC, Ciuffreda D, Cooperrider JH, Tomlinson M, Hauck GD, Aneja J, Berger C, Wolski D, Carrington M, Wherry EJ, Chung RT, Tanabe KK, Elias N, Freeman GJ, de Kruyff RH, Misdraji J, Kim AY, Lauer GM (2014) Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors. Gastroenterology 146:550–561. https://doi.org/10.1053/j.gastro.2013.10.022

    Article  PubMed  Google Scholar 

  • Kulkeaw K (2021) Next-generation human liver models for antimalarial drug assays. Antibiotics (Basel). 10(6):642. https://doi.org/10.3390/antibiotics10060642. PMID: 34071885; PMCID: PMC8229011

  • March S, Ng S, Velmurugan S, Galstian A, Shan J, Logan DJ, Carpenter AE, Thomas D, Sim BK, Mota MM, Hoffman SL, Bhatia SN (2013) A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax. Cell Host Microbe 14:104–115. https://doi.org/10.1016/j.chom.2013.06.005

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Meunier L, Larrey D (2019) Drug-induced liver injury: biomarkers, requirements, candidates, and validation. Front Pharmacol 10:1482. https://doi.org/10.3389/fphar.2019.01482

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mun SJ, Ryu JS, Lee MO, Son YS, Oh SJ, Cho HS, Son MY, Kim DS, Kim SJ, Yoo HJ, Lee HJ, Kim J, Jung CR, Chung KS, Son MJ (2019) Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids. J Hepatol 71:970–985. https://doi.org/10.1016/j.jhep.2019.06.030

    Article  CAS  PubMed  Google Scholar 

  • Ng S, Schwartz RE, March S, Galstian A, Gural N, Shan J, Prabhu M, Mota MM, Bhatia SN (2015) Human iPSC-derived hepatocyte-like cells support Plasmodium liver-stage infection in vitro. Stem Cell Reports 4:348–359. https://doi.org/10.1016/j.stemcr.2015.01.002

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ogawa M, Ogawa S, Bear CE, Ahmadi S, Chin S, Li B, Grompe M, Keller G, Kamath BM, Ghanekar A (2015) Directed differentiation of cholangiocytes from human pluripotent stem cells. Nat Biotechnol 33:853–861. https://doi.org/10.1038/nbt.3294

    Article  CAS  PubMed  Google Scholar 

  • Phan TD, Eastwood JP, Shay MA, Drake JF, Sonnerup BUO, Fujimoto M, Cassak PA, Oieroset M, Burch JL, Torbert RB, Rager AC, Dorelli JC, Gershman DJ, Pollock C, Pyakurel PS, Haggerty CC, Khotyaintsev Y, Lavraud B, Saito Y, Oka M, Ergun RE, Retino A, Le Contel O, Argall MR, Giles BL, Moore TE, Wilder FD, Strangeway RJ, Russell CT, Lindqvist PA, Magnes W (2019) Publisher correction: electron magnetic reconnection without ion coupling in Earth’s turbulent magnetosheath. Nature 569:E9. https://doi.org/10.1038/s41586-019-1208-1

    Article  CAS  PubMed  Google Scholar 

  • Pollmann J, Gotz JJ, Rupp D, Strauss O, Granzin M, Grunvogel O, Mutz P, Kramer C, Lasitschka F, Lohmann V, Bjorkstrom NK, Thimme R, Bartenschlager R, Cerwenka A (2018) Hepatitis C virus-induced natural killer cell proliferation involves monocyte-derived cells and the OX40/OX40L axis. J Hepatol 68:421–430. https://doi.org/10.1016/j.jhep.2017.10.021

    Article  CAS  PubMed  Google Scholar 

  • Radziewicz H, Ibegbu CC, Fernandez ML, Workowski KA, Obideen K, Wehbi M, Hanson HL, Steinberg JP, Masopust D, Wherry EJ, Altman JD, Rouse BT, Freeman GJ, Ahmed R, Grakoui A (2007) Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. J Virol 81:2545–2553. https://doi.org/10.1128/JVI.02021-06

    Article  CAS  PubMed  Google Scholar 

  • Schlaermann P, Toelle B, Berger H, Schmidt SC, Glanemann M, Ordemann J, Bartfeld S, Mollenkopf HJ, Meyer TF (2016) A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro. Gut 65:202–213. https://doi.org/10.1136/gutjnl-2014-307949

    Article  CAS  PubMed  Google Scholar 

  • Shinozawa T, Kimura M, Cai Y, Saiki N, Yoneyama Y, Ouchi R, Koike H, Maezawa M, Zhang RR, Dunn A, Ferguson A, Togo S, Lewis K, Thompson WL, Asai A, Takebe T (2021) High-Fidelity drug-induced liver injury screen using human pluripotent stem cell-derived organoids. Gastroenterology 160(831–846):e810. https://doi.org/10.1053/j.gastro.2020.10.002

    Article  CAS  Google Scholar 

  • Takayama K, Kawabata K, Nagamoto Y, Kishimoto K, Tashiro K, Sakurai F, Tachibana M, Kanda K, Hayakawa T, Furue MK, Mizuguchi H (2013) 3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing. Biomaterials 34:1781–1789. https://doi.org/10.1016/j.biomaterials.2012.11.029

    Article  CAS  PubMed  Google Scholar 

  • Vlachogiannis G, Hedayat S, Vatsiou A, Jamin Y, Fernandez-Mateos J, Khan K, Lampis A, Eason K, Huntingford I, Burke R, Rata M, Koh DM, Tunariu N, Collins D, Hulkki-Wilson S, Ragulan C, Spiteri I, Moorcraft SY, Chau I, Rao S, Watkins D, Fotiadis N, Bali M, Darvish-Damavandi M, Lote H, Eltahir Z, Smyth EC, Begum R, Clarke PA, Hahne JC, Dowsett M, de Bono J, Workman P, Sadanandam A, Fassan M, Sansom OJ, Eccles S, Starling N, Braconi C, Sottoriva A, Robinson SP, Cunningham D, Valeri N (2018) Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Science 359:920–926. https://doi.org/10.1126/science.aao2774

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wroblewski LE, Piazuelo MB, Chaturvedi R, Schumacher M, Aihara E, Feng R, Noto JM, Delgado A, Israel DA, Zavros Y, Montrose MH, Shroyer N, Correa P, Wilson KT, Peek RM Jr (2015) Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Gut 64:720–730. https://doi.org/10.1136/gutjnl-2014-307650

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Kulkeaw, K. (2023). The Use of 3D In Vitro Systems to Model Human Malaria. In: Emergence of In Vitro 3D Systems to Model Human Malaria. Springer, Singapore. https://doi.org/10.1007/978-981-99-0691-8_6

Download citation

Publish with us

Policies and ethics