Abstract
Human breast milk produced by the mammary glands is a complex biological fluid. The components of breast milk serve the function of nutrition and development of immune system for newborns. The bioactive factors in breast milk consists of nutritional elements along with a wide variety of immunological factors, anti-inflammatory agents and cells. The composition of milk changes in different stages of lactation suiting the needs of the newborn. The cellular composition of breast milk; especially the stem cell population is of great interest for researchers regarding its functions in newborn and its possible applications in regenerative medicine. The nature of breast milk derived stem cells needs to be characterized to explore the potential role of breast milk in regeneration and neurological functions.
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References
Akers RM (2016) Lactation and the mammary gland. Blackwell Publishing Company, Ames, Iowa
Alsaweed M, Hartmann P, Geddes D, Kakulas F (2015) MicroRNAs in breastmilk and the lactating breast: potential immunoprotectors and developmental regulators for the infant and the mother. Int J Environ Res Public Health 12:13981–14020. https://doi.org/10.3390/ijerph121113981
Bardanzellu F, Peroni DG, Fanos V (2020) Human breast milk: bioactive components, from stem cells to health outcomes. Curr Nutr Rep 9:1–13. https://doi.org/10.1007/s13668-020-00303-7
Bode L, McGuire M, Rodriguez JM et al (2014) It’s alive: microbes and cells in human milk and their potential benefits to mother and infant. Adv Nutr 5:571–573. https://doi.org/10.3945/an.114.006643
Brisken C, O’Malley B (2010) Hormone action in the mammary gland. Cold Spring Harb Perspect Biol 2:a003178. https://doi.org/10.1101/cshperspect.a003178
Cabinian A, Sinsimer D, Tang M et al (2016) Transfer of maternal immune cells by breastfeeding: maternal cytotoxic T lymphocytes present in breast milk localize in the Peyer’s patches of the nursed infant. PLoS One 11:e0156762. https://doi.org/10.1371/journal.pone.0156762
Clayton H, Titley I, Vivanco MM (2004) Growth and differentiation of progenitor/stem cells derived from the human mammary gland. Exp Cell Res 297:444–460. https://doi.org/10.1016/j.yexcr.2004.03.029
Cregan MD, Fan Y, Appelbee A et al (2007) Identification of nestin-positive putative mammary stem cells in human breastmilk. Cell Tissue Res 329:129–136. https://doi.org/10.1007/s00441-007-0390-x
Ercan C, van Diest PJ, Vooijs M (2011) Mammary development and breast cancer: the role of stem cells. Curr Mol Med 11:270–285. https://doi.org/10.2174/156652411795678007
Evans PW, Wheeler T, Anthony FW, Osmond C (1998) A longitudinal study of maternal serum vascular endothelial growth factor in early pregnancy. Hum Reprod 13:1057–1062. https://doi.org/10.1093/humrep/13.4.1057
Fan Y, Chong YS, Choolani MA et al (2010) Unravelling the mystery of stem/progenitor cells in human breast milk. PLoS One 5:e14421. https://doi.org/10.1371/journal.pone.0014421
Field CJ (2005) The immunological components of human milk and their effect on immune development in infants. J Nutr 135:1–4. https://doi.org/10.1093/jn/135.1.1
Ghosh A (2020) Breast milk stem cell survival in neonate’s gut, entery into neonate circulation and adaption by the body. Curr Stem Cell Res Ther 15:98–101. https://doi.org/10.2174/1574888X14666191107095728
Goudarzi N, Shabani R, Ebrahimi M et al (2020) Comparative phenotypic characterization of human colostrum and breast milk-derived stem cells. Hum Cell 33:308–317. https://doi.org/10.1007/s13577-019-00320-x
Harbell JW, Bowman PD, Shannon JM, Daniel CW (1977) Long-term organ culture of mouse mammary gland. In Vitro 13:490–496. https://doi.org/10.1007/BF02615141
Hartmann PE (2007) The lactating breast: an overview from down under. Breastfeed Med 2:3–9. https://doi.org/10.1089/bfm.2006.0034
Hassiotou F, Geddes D (2013) Anatomy of the human mammary gland: current status of knowledge. Clin Anat 26:29–48. https://doi.org/10.1002/ca.22165
Hassiotou F, Geddes DT (2015) Immune cell-mediated protection of the mammary gland and the infant during breastfeeding. Adv Nutr 6:267–275. https://doi.org/10.3945/an.114.007377
Hassiotou F, Hartmann PE (2014) At the dawn of a new discovery: the potential of breast milk stem cells. Adv Nutr 5:770–778. https://doi.org/10.3945/an.114.006924
Hassiotou F, Beltran A, Chetwynd E et al (2012) Breastmilk is a novel source of stem cells with multilineage differentiation potential. Stem Cells 30:2164–2174. https://doi.org/10.1002/stem.1188
Hosseini SM, Talaei-khozani T, Sani M, Owrangi B (2014) Differentiation of human breast-milk stem cells to neural stem cells and neurons. Neurol Res Int 2014:1–8. https://doi.org/10.1155/2014/807896
Indumathi S, Dhanasekaran M, Rajkumar JS, Sudarsanam D (2013) Exploring the stem cell and non-stem cell constituents of human breast milk. Cytotechnology 65:385–393. https://doi.org/10.1007/s10616-012-9492-8
Jones C, Mackay A, Grigoriadis A et al (2004) Expression profiling of purified normal human luminal and myoepithelial breast cells. Cancer Res 64:3037–3045. https://doi.org/10.1158/0008-5472.CAN-03-2028
Kaingade PM, Somasundaram I, Nikam AB et al (2016) Breastmilk-derived mesenchymal stem cells in vitro are likely to be mediated through epithelial–mesenchymal transition. Breastfeed Med 11:152–152. https://doi.org/10.1089/bfm.2016.0023
Knight CH, Peaker M (1982) Development of the mammary gland. Reproduction 65:521–536. https://doi.org/10.1530/jrf.0.0650521
Kosaka N, Izumi H, Sekine K, Ochiya T (2010) microRNA as a new immune-regulatory agent in breast milk. Silence 1:7. https://doi.org/10.1186/1758-907X-1-7
Mane S, Taneja S, Madala JS et al (2022) Study of stem cells in human milk. Cureus 14:e23701. https://doi.org/10.7759/cureus.23701
Neville MC, McFadden TB, Forsyth I (2002) Hormonal regulation of mammary differentiation and milk secretion. J Mammary Gland Biol Neoplasia 7:49–66. https://doi.org/10.1023/A:1015770423167
Newburg DS (2005) Innate immunity and human milk. J Nutr 135:1308–1312. https://doi.org/10.1093/jn/135.5.1308
Patki S, Kadam S, Chandra V, Bhonde R (2010) Human breast milk is a rich source of multipotent mesenchymal stem cells. Hum Cell 23:35–40. https://doi.org/10.1111/j.1749-0774.2010.00083.x
Patki S, Patki U, Patil R et al (2012) Comparison of the levels of the growth factors in umbilical cord serum and human milk and its clinical significance. Cytokine 59:305–308. https://doi.org/10.1016/j.cyto.2012.04.010
Rahmani-Moghadam E, Zarrin V, Mahmoodzadeh A et al (2022) Comparison of the characteristics of breast milk-derived stem cells with the stem cells derived from the other sources: a comparative review. Curr Stem Cell Res Ther 17:71–90. https://doi.org/10.2174/1574888X16666210622125309
Rudland PS, Barraclough R, Fernig DG, Smith JA (1997) Mammary stem cells in normal development and cancer. In: Stem cells. Elsevier, pp 147–232
Sani M, Hosseini SM, Salmannejad M et al (2015) Origins of the breast milk-derived cells; an endeavor to find the cell sources. Cell Biol Int 39:611–618. https://doi.org/10.1002/cbin.10432
Schack-Nielsen L, Michaelsen KF (2006) Breast feeding and future health. Curr Opin Clin Nutr Metab Care 9:289–296. https://doi.org/10.1097/01.mco.0000222114.84159.79
Sharp JA, Lefèvre C, Watt A, Nicholas KR (2016) Analysis of human breast milk cells: gene expression profiles during pregnancy, lactation, involution, and mastitic infection. Funct Integr Genomics 16:297–321. https://doi.org/10.1007/s10142-016-0485-0
Trend S, de Jong E, Lloyd ML et al (2015) Leukocyte populations in human preterm and term breast Milk identified by multicolour flow cytometry. PLoS One 10:e0135580. https://doi.org/10.1371/journal.pone.0135580
Twigger A-J, Hepworth AR, Tat Lai C et al (2015) Gene expression in breastmilk cells is associated with maternal and infant characteristics. Sci Rep 5:12933. https://doi.org/10.1038/srep12933
Witkowska-Zimny M, Kaminska-El-Hassan E (2017) Cells of human breast milk. Cell Mol Biol Lett 22:11. https://doi.org/10.1186/s11658-017-0042-4
Wold AE, Adlerberth I (1998) Does breastfeeding affect the infant’s immune responsiveness? Acta Paediatr 87:19–23. https://doi.org/10.1080/08035259850157804
World Health Organization, UNICEF (2003) Global strategy for infant and young child feeding. World Health Organization
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Somasundaram, I., Kaingade, P., Bhonde, R. (2023). Components of Breast Milk: An Overview. In: Stem cell and Non-stem Cell Components of Breast Milk. Springer, Singapore. https://doi.org/10.1007/978-981-99-0647-5_1
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DOI: https://doi.org/10.1007/978-981-99-0647-5_1
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