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Diet-Gene Interactions that Regulate Longevity and Diseases

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Evidence-based Functional Foods for Prevention of Age-related Diseases

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Abstract

Aging, an almost universal phenomenon, encompasses a gradual yet constant deterioration of the metabolic functions of the body. Aging is characterized by an increased homeostatic imbalance and an elevated risk of systemic metabolic failures leading to diseases, with the ultimate outcome being death. Age-related metabolic disorders, such as cardiovascular diseases and type-2 diabetes, are among the major causes of mortality worldwide. A plethora of research has established that aging is regulated by genes functioning in important metabolic pathways. Thus quite expectedly, the nutrient content of a diet has been found to modulate the lifespan of an organism and define the severity or course of several age-related or other illnesses. Under normal conditions, an organism can modulate its gene expression to adapt to these diet-induced metabolic changes to display normal health and lifespan. However, in the presence of an altered allele, the effects of diet or one of its components may become apparent in terms of health, disease, or longevity effects. Identifying such diet-gene pairs and the associated molecular mechanisms is necessary for developing dietary and therapeutic interventions that would prevent or treat diseases and promote healthy aging.

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Abbreviations

AD:

Alzheimer’s disease

ALH-6:

ALdehyde Dehydrogenase

AMD:

Age-related macular degeneration

APOA5:

APOlipoprotein A-V

APOE:

APOlipoprotein E

ATP7B:

ATPase copper transporting 7 Beta

ATPsynD:

ATP synthase subunit D

BCAA:

Branched-chain amino acids

BRS-3:

Bombesin Receptor Subtype 3

CCHa2R:

CCHamide-2 Receptor

CVD:

Cardiovascular diseases

DGRP:

Drosophila genetic reference panel

DTT:

Dithiothreitol

ech-6:

Enoyl-CoA hydratase

FLR-4:

FLuoRide resistant 4

FTO:

FaT mass and Obesity

GLUT:

GLUcose Transporter

GSTM1:

Glutathione S-Transferase Mu

HC:

High caloric

HDL:

High-density lipoprotein

HMGCR:

3-Hydroxy-3-MethylGlutaryl-Coenzyme A Reductase

HNF4:

Hepatocyte Nuclear Factor 4

HP-LS:

High protein and low sugar

HS-LP:

High sugar and low protein

IRS1:

Insulin Receptor Substrate 1

LD:

Lipid droplets

LDL:

Low-density lipoprotein

LPS:

LipoPolySaccharide

MAPK:

Mitogen activated protein kinase

MEF2:

Myocyte Enhancer Factor 2

MRPL-2:

Mitochondrial Ribosomal Protein Like 2

MTHFR:

MethylTetraHydroFolate Reductase

MUFA:

Monounsaturated fatty acids

NAD(P)H:

Nicotinamide adenine dinucleotide phosphate reduced

NHR-114:

Nuclear Hormone Receptor 114

NMUR-1:

NeuroMedin U Receptor 1

NRF2:

NF-E2-Related transcription factor

OSM-3:

OSMotic avoidance abnormal

P5C:

1-Pyrroline-5-carboxylate

P-80:

Polysorbate 80

PLP:

PyridoxaL 5’-phosphate

PMT-2:

Phosphatidylethanolamine MethylTransferase 2

PNPO:

Pyridox(am)iNe 5-Phosphate Oxidase

PUFA:

PolyUnsaturated fatty acids

RANKL:

Receptor Activator of Nuclear factor-Kappa-Î’ Ligand

RICT-1:

Rapamycin-Insensitive Companion of TOR

RIPS-1:

Rhy-1-Interacting Protein in Sulfide

RPE:

Retinal pigmented epithelium

SAM:

S-adenosyl methionine

SIRT-6:

NAD+-dependent deacetylase (SIRTuin-6)

SKN-1:

SKiNhead 1

SNP:

Single nucleotide polymorphism

SOD2:

SuperOxide Dismutase 2

Spen:

Split ends

T2DM:

Type-2 diabetes mellitus

TCF7L2:

TransCription Factor 7-Like 2

TG:

Triglyceride

TNFα:

Tumor Necrosis Factor-alpha

UPRmt:

Mitochondrial unfolded protein response

ZPR1:

Zinc finger PRotein-1

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Authors and Affiliations

  1. Molecular Aging Laboratory, National Institute of Immunology, New Delhi, India

    Tripti Nair & Arnab Mukhopadhyay

  2. Division of Neuroscience and Ageing Biology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

    Sonia Verma

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  1. Tripti Nair
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  2. Sonia Verma
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  3. Arnab Mukhopadhyay
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Correspondence to Arnab Mukhopadhyay .

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Editors and Affiliations

  1. Faculty of Allied Health Sciences, Chettinad Hospital & Research Institute, Chettinad Academy of Research and Education, Chennai, Tamil Nadu, India

    Surajit Pathak

  2. Faculty of Allied Health Sciences, Chettinad Hospital & Research Institute, Chettinad Academy of Research and Education, Chennai, Tamil Nadu, India

    Antara Banerjee

  3. Department of Nutrition, Faculty of Medicine, Institute of Basic Medical SciencesUniversity of Oslo, Oslo, Norway

    Asim K. Duttaroy

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Nair, T., Verma, S., Mukhopadhyay, A. (2023). Diet-Gene Interactions that Regulate Longevity and Diseases. In: Pathak, S., Banerjee, A., Duttaroy, A.K. (eds) Evidence-based Functional Foods for Prevention of Age-related Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-99-0534-8_3

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