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Thermal Stress and Nuclear Transport

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Thermal Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1461))

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Abstract

Nuclear transport is the basis for the biological reaction of eukaryotic cells, as it is essential to coordinate nuclear and cytoplasmic events separated by nuclear envelope. Although we currently understand the basic molecular mechanisms of nuclear transport in detail, many unexplored areas remain. For example, it is believed that the regulations and biological functions of the nuclear transport receptors (NTRs) highlights the significance of the transport pathways in physiological contexts. However, physiological significance of multiple parallel transport pathways consisting of more than 20 NTRs is still poorly understood, because our knowledge of each pathway, regarding their substrate information or how they are differently regulated, is still limited. In this report, we describe studies showing how nuclear transport systems in general are affected by temperature rises, namely, thermal stress or heat stress. We will then focus on Importin α family members and unique transport factor Hikeshi, because these two NTRs are affected in heat stress. Our present review will provide an additional view to point out the importance of diversity of the nuclear transport pathways in eukaryotic cells.

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Authors and Affiliations

  1. Cellular Dynamics Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan

    Shingo Kose, Yutaka Ogawa & Naoko Imamoto

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  1. Shingo Kose
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  2. Yutaka Ogawa
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  3. Naoko Imamoto
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Correspondence to Shingo Kose , Yutaka Ogawa or Naoko Imamoto .

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  1. Division of Cell Signaling, Okazaki Institute for Integrative Bioscience (National Institute for Physiological Sciences), Okazaki, Aichi, Japan

    Makoto Tominaga

  2. School of Materials Science, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa, Japan

    Masahiro Takagi

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Kose, S., Ogawa, Y., Imamoto, N. (2024). Thermal Stress and Nuclear Transport. In: Tominaga, M., Takagi, M. (eds) Thermal Biology. Advances in Experimental Medicine and Biology, vol 1461. Springer, Singapore. https://doi.org/10.1007/978-981-97-4584-5_5

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