Abstract
X-ray diffraction and Raman studies of human femur in knee compartment under osteoarthritis conditions are performed. The measurements have demonstrated the systematic site-dependent changes in crystal cell parameters and molecular dynamics in calcium hydroxyapatite in subchondral bone. To investigate the origin of the changes and to link them with the mechanical loads in the skeleton, relationships between the site-dependent changes in crystal cell volume and Raman shifts of the symmetric PāO stretching of PO43ā ions are examined. Small but distinct displacements of the v1PO43ā band in the Raman spectra of subchondral bone on the proximal side are detected and assigned with the expansion of crystal cell and the peculiarities of biomechanics in knee joint. Combination of X-ray diffraction and Raman probing of mechanical loads in subchondral bone is discussed.
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Acknowledgements
This work is financially supported by Russian Science Foundation Grant 23-29-00172. This research was carried out with the technical support of the Centre for Physical Methods of Surface Investigation, Centre for Diagnostics of Functional Materials for Medicine, Pharmacology and Nanoelectronics, Centre for X-ray Diffraction Studies and Centre for Optical and Laser Methods for Studying Matter at St. Petersburg State University.
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Pavlychev, A., Brykalova, X., Cherny, A., Konashuk, A., Korneev, A. (2024). Mechanical Loads and Site-Dependent Changes in Crystal Structure and Molecular Dynamics in Native Bone. In: Yue, X., Yuan, K. (eds) Proceedings of 2023 the 6th International Conference on Mechanical Engineering and Applied Composite Materials. MEACM 2023. Mechanisms and Machine Science, vol 156. Springer, Singapore. https://doi.org/10.1007/978-981-97-1678-4_33
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