Plant Viral Vectors: Important Tools for Biologics Production

Kulshreshtha, Aditya; Mandadi, Kranthi K.

doi:10.1007/978-981-97-0176-6_1

Aditya Kulshreshtha⁶ &
Kranthi K. Mandadi^6,7,8

Part of the book series: Concepts and Strategies in Plant Sciences ((CSPS))

51 Accesses

Abstract

Plants have enormous potential for producing a wide range of biologics and therapeutics. Compared to bacterial and mammalian systems, production in plants is faster, inexpensive, and free from animal pathogens or toxins. Plant-infecting viruses can be engineered to express gene(s) for many monoclonal antibodies, vaccines, and other therapeutic proteins inside plant tissues. Their utility does not necessitate steady transgenic expression, allowing therapeutic proteins to be produced in large amounts in a short period. Plant virus-based vaccines can also stimulate immunogenic responses against human pathogens. This chapter describes plant virus-based expression systems and their utility in the production of various biologics and biopharmaceutical products. It also highlights the current progress and limitations of the virus-expression platforms.

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Abbreviations

ACEI:: Angiotensin-I-converting enzyme inhibitor
ACMV:: African cassava mosaic virus
ACT2:: Actin 2
AD:: Alzheimer’s disease
aFGF:: Acidic fibroblast growth factor
Ag:: Antigen
Aβ:: Amyloid β
BaMV:: Bamboo mosaic virus
BCTV:: Beet curly top virus
BeYDV:: Bean yellow dwarf virus
bFGF:: Basic fibroblast growth factor
BMV:: Brome mosaic virus
BvLz:: Bovine lysozyme
CaMV:: Cauliflower mosaic virus
CAT:: Chloramphenicol acetyltransferase
CCMV:: Cowpea chlorotic mottle virus
CHO:: Chinese hamster ovary
CMV:: Cucumber mosaic virus
COPV:: Canine oral papillomavirus
CP:: Coat protein
CPMV:: Cowpea mosaic virus
CPSMV:: Cowpea severe mosaic virus
CPV:: Canine parvovirus
CRPV:: Cottontail rabbit papillomavirus
CTBp:: Cholera toxin B subunit
CTV:: Citrus tristeza virus
DHFR:: Dihydrofolate reductase
FDA:: Food and Drug Administration
FMDV:: Foot-and-mouth disease virus
GFP:: Green fluorescent protein
GMMV:: Gayfeather mild mottle virus
GNA:: Galanthus nivalis agglutinin
HBc:: Hepatitis B core antigen
HBcAg:: Hepatitis B virus core antigen
HIV-1:: Human immunodeficiency virus 1
HPV-16:: Human papillomavirus type 16
HPV-8:: Human papillomavirus type 8
HRV 14:: Human rhinovirus 14
IFN αD:: Interferon αD
IP:: Intraperitoneal
mAbs:: Monoclonal antibodies
MDBK:: Madin-Darby bovine kidney
MMAE:: Monomethyl auristatin E
MP:: Movement protein
NDV:: Newcastle disease virus
NHL:: Non-Hodgkin’s B cell lymphomas
NMV:: Narcissus mosaic virus
NVCP:: Norwalk virus capsid protein
PCV:: Porcine circovirus
PEBV:: Pea early-browning virus
PepMV:: Pepino mosaic virus
PepRSV:: Pepper ringspot virus
PPV:: Plum pox potyvirus
PSV:: Peanut stunt virus
PVA:: Potato virus A
PVX:: Potato virus X
RBD:: Receptor-binding domain
SYNV:: Sonchus yellow net virus
TACA:: Tumor-associated hydrate antigen
TBSV:: Tomato bushy stunt virus
TLR:: Toll-like receptor
TMV:: Tobacco mosaic virus
TRBO:: TMV RNA-based overexpression
TRSV:: Tobacco ringspot virus
TRV:: Tobacco rattle virus
TSV:: Tomato aspermy virus
TVCV:: Turnip vein-clearing virus
Ubi:: Ubiquitin 1
USDA:: US Department of Agriculture
VEGF:: Vascular endothelial growth factor
VLP:: Viruslike particle
zDIII:: Zika virus E protein domain III
ZYMV:: Zucchini yellow mosaic virus

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Acknowledgments

This study was supported partly by funds from USDA-NIFA (HATCH 1023984; 2021-70029-36056) and Texas A&M AgriLife Research Insect-vectored Disease Seed Grants (124185-96210) to K.M.

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Texas A&M AgriLife Research and Extension Center, Texas A&M University System, Weslaco, Texas, USA
Aditya Kulshreshtha & Kranthi K. Mandadi
Department of Plant Pathology and Microbiology, Texas A&M University, College Station, Texas, USA
Kranthi K. Mandadi
Institute for Advancing Health Through Agriculture, Texas A&M AgriLife, College Station, Texas, USA
Kranthi K. Mandadi

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Aditya Kulshreshtha
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Correspondence to Kranthi K. Mandadi .

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Chairman, Prof. Chittaranjan Kole Foundation for Science and Society, Kolkata, India
Chittaranjan Kole
ICAR-Indian Institute of Vegetable Research, Varanasi, India
Anurag Chaurasia
Dept of Microbiology, Cornell University, Ithaca, NY, NY, USA
Kathleen L. Hefferon
Professor & Head, Department of Biotechnology, Coordinator, Centre of Excellence on Bioprospecting of Ethnopharmaceuticals of Southern Odisha (CoEBESO),, Berhampur University, Berhampur, India
Jogeswar Panigrahi

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Kulshreshtha, A., Mandadi, K.K. (2024). Plant Viral Vectors: Important Tools for Biologics Production. In: Kole, C., Chaurasia, A., Hefferon, K.L., Panigrahi, J. (eds) Applications of Plant Molecular Farming. Concepts and Strategies in Plant Sciences. Springer, Singapore. https://doi.org/10.1007/978-981-97-0176-6_1

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DOI: https://doi.org/10.1007/978-981-97-0176-6_1
Published: 19 April 2024
Publisher Name: Springer, Singapore
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Online ISBN: 978-981-97-0176-6
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