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Overview of Decellularized Materials for Tissue Repair and Organ Replacement

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Book cover Decellularized Materials

Abstract

Decellularized materials (DMs) including decellularized tissues and organs are derived from natural tissues and organs through decellularization process removing cells and other antigenic components. They keep main components of natural ECM, exhibiting satisfactory bioactivities and being widely applied in tissue repair. Especially, the remain of macro and microstructures of native organs to some extent provides them superiorities on organ replacement. Hence, they have attracted wide attention, and further studies about them would be conducted. In this chapter, the background, preparation, and composition and structure of DMs were introduced. Then, the degradation of DMs and their mechanisms of promoting tissue regeneration/organ replacement was discussed in detail through two aspects including: (1) initiating relatively low host tissue response to provide appropriate regeneration microenvironment; (2) containing bioactive factors to recruit endogenous stems/progenitor cells and promote matrix production and angiogenesis. In addition, decellularized tissues and their applications, as well as decellularized organs and their recellularization were briefly introduced. Finally, the structure and main content of this book were expatiated.

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  1. Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China

    Jie Liao, Qi Guo, Bo Xu & Xiaoming Li

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  1. Jie Liao
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  2. Qi Guo
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  3. Bo Xu
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  4. Xiaoming Li
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  1. Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China

    Xiaoming Li

  2. Laboratory of Stem Cell and Tissue Engineering Orthopedic Research Institute State Key Laboratory of Biotherapy and Cancer Center, West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China

    Huiqi Xie

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Liao, J., Guo, Q., Xu, B., Li, X. (2021). Overview of Decellularized Materials for Tissue Repair and Organ Replacement. In: Li, X., Xie, H. (eds) Decellularized Materials. Springer, Singapore. https://doi.org/10.1007/978-981-33-6962-7_1

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