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Bioinspired Hierarchically Structured Polymer Interfaces for Promising Biomedical Applications

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Microfabrication of Stimuli-Responsive Polymers

Abstract

In this chapter, the development of novel bio-inspired surfaces with hierarchical micro- and nanoscale topographic structures for efficient capture and release of circulating tumor cells (CTCs) is reported. The three-dimensional hierarchically structured surfaces were facilely fabricated by replicating the natural micro- and nanostructures of rose petals onto polydimethylsiloxane (PDMS) substrates.

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References

  1. Sekine J, Luo SC, Wang ST, Zhu B, Tseng HR, Yu HH (2011) Functionalized conducting polymer nanodots for enhanced cell capturing: the synergistic effect of capture agents and nanostructures. Adv Mater 23:4788–4792

    Article  CAS  Google Scholar 

  2. Liu XL, Chen L, Liu HL, Yang G, Zhang PC, Han D, Wang ST, Jiang L (2013) Bio-inspired soft polystyrene nanotube substrate for rapid and highly efficient breast cancer-cell capture. NPG Asia Mater 5:e63

    Article  CAS  Google Scholar 

  3. Liu MX, He R, Yang J, Zhao W, Zhou CR (2016) Stripe-like clay nanotubes patterns in glass capillary tubes for capture of tumor cell. ACS Appl Mater Interf 8:7709–7719

    Article  CAS  Google Scholar 

  4. Wang SQ, Wan Y, Liu YL (2014) Effects of nanopillar array diameter and spacing on cancer cell capture and cell behaviors. Nanoscale 6:12482–12489

    Article  CAS  Google Scholar 

  5. Liu HL, Li YY, Sun K, Fan JB, Zhang PC, Meng JX, Wang ST, Jiang L (2013) Dual-responsive surfaces modified with phenylboronic acid-containing polymer brush to reversibly capture and release cancer cells. J Am Chem Soc 135:7603–7609

    Article  CAS  Google Scholar 

  6. Zhang NG, Deng YL, Tai QD, Cheng BR, Zhao LB, Shen QL, He RX, Hong LY, Liu W, Guo SS, Liu K, Tseng HR, Xiong B, Zhao XZ (2012) Electrospun TiO2 nanofiber-based cell capture assay for detecting circulating tumor cells from colorectal and gastric cancer patients. Adv Mater 24:2756–2760

    Article  CAS  Google Scholar 

  7. Zhao YL, Fan ZY, Shen MW, Shi XY (2015) Hyaluronic acid-functionalized electrospun polyvinyl alcohol/polyethyleneimine nanofibers for cancer cell capture applications. Adv Mater Interf 2:1500256

    Article  Google Scholar 

  8. Lee SK, Kim GS, Wu Y, Kim DJ, Lu Y, Kwak M, Han L, Hyung JH, Seol JK, Sander C, Gonzalez A, Li J, Fan R (2012) Nanowire substrate-based laser scanning cytometry for quantitation of circulating tumor cells. Nano Lett 12:2697–2704

    Article  CAS  Google Scholar 

  9. Lv SW, Liu Y, Xie M, Wang J, Yan XW, Li Z, Dong WG, Huang WH (2016) Near-infrared light-responsive hydrogel for specific recognition and photothermal site-release of circulating tumor cell. ACS Nano 10:6201–6210

    Article  CAS  Google Scholar 

  10. Zhang PC, Chen L, Xu TL, Liu HL, Liu XL, Meng JX, Yang G, Jiang L, Wang ST (2013) Programmable fractal nanostructured interfaces for specific recognition and electrochemical release of cancer cells. Adv Mater 25:3566–3570

    Article  CAS  Google Scholar 

  11. Wang LY, Liu HL, Zhang FL, Li GN, Wang ST (2016) Smart thin hydrogel coating harnessing hydrophobicity and topography to capture and release cancer cells. Small 12:4691–4701

    Google Scholar 

  12. Wang ST, Wang H, Jiao J, Chen KJ, Owens GE, Kamei KI, Sun J, Sherman DJ, Behrenbruch CP, Wu H, Tseng HR (2009) Three-dimensional nanostructured substrates toward efficient capture of circulating tumor cells. Angew Chem Int Ed 48:8970–8973

    Article  CAS  Google Scholar 

  13. Pardoll DT (2002) Cells take aim at cancer. Proc Natl Acad Sci U S A 99:15840–15842

    Article  CAS  Google Scholar 

  14. Araque A, Navarrete M (2011) Electrically driven insulation in the central nervous system. Science 333:1587–1588

    Article  CAS  Google Scholar 

  15. Liu XL, Wang ST (2014) Three-dimensional nano-biointerfaces as a new platform for guiding cell fate. Chem Soc Rev 43:2385–2401

    Article  CAS  Google Scholar 

  16. Meng JX, Liu HL, Liu XL, Yang G, Zhang PC, Wang ST, Jiang L (2014) Hierarchical biointerfaces assembled by leukocyte-inspired particles for specifically recognizing cancer cells. Small 10:3735–3741

    Article  CAS  Google Scholar 

  17. Zhang FL, Jiang Y, Liu XL, Meng JX, Zhang PC, Liu HL, Yang G, Li GN, Jiang L, Wan LJ, Hu JS, Wang ST (2016) Hierarchical nanowire arrays as three-dimensional fractal nanobiointerfaces for high efficient capture of cancer cells. Nano Lett 16:766–772

    Article  CAS  Google Scholar 

  18. Kwak W, Hwang W (2016) Facile method for preparing superoleophobic surfaces with hierarchical microcubic/nanowire structures. Nanotechnology 27:055301

    Article  Google Scholar 

  19. Tang C, Li BQ, Zhang Q, Zhu L, Wang HF, Shi JL, Wei F (2016) CaO-templated growth of hierarchical porous graphene for high-power lithium-sulfur battery applications. Adv Funct Mater 26:577–585

    Article  CAS  Google Scholar 

  20. Liu XL, Zhang FL, Wang Q, Gao J, Meng JX, Wang ST, Yang ZZ, Jiang L (2014) Platelet-inspired multiscaled cytophilic interfaces with high specificity and efficiency toward point-of-care cancer diagnosis. Small 10:4677–4683

    Article  CAS  Google Scholar 

  21. Ma L, Yang G, Wang N, Zhang PC, Guo FY, Meng JX, Zhang FL, Hu ZJ, Wang ST, Zhao Y (2015) Trap effect of three-dimensional fibers network for high efficient cancer-cell capture. Adv Healthcare Mater 4:838–843

    Article  CAS  Google Scholar 

  22. Hasan H, Schroers J, Kumar G (2015) Functionalization of metallic glasses through hierarchical patterning. Nano Lett 15:963–968

    Article  CAS  Google Scholar 

  23. Morariu MD, Voicu NE, Schäffer E, Lin ZQ, Russell TP, Steiner U (2003) Hierarchical structure formation and pattern replication induced by an electric field. Nat Mater 2:48–52

    Article  CAS  Google Scholar 

  24. Dou XQ, Zhang D, Feng CL, Jiang L (2015) Bioinspired hierarchical surface structure with tunable wettability for regulating bacteria adhesion. ACS Nano 9:10664–10672

    Article  CAS  Google Scholar 

  25. Rogers JA, Nuzzo RG (2005) Recent progress in soft lithography. Mater Today 8:50–56

    Article  CAS  Google Scholar 

  26. Discher DE, Mooney DJ, Zandstra PW (2009) Growth factors, matrices, and forces combine and control stem cells. Science 324:1673–1677

    Article  CAS  Google Scholar 

  27. Went PT, Lugli A, Meier S, Bundi M, Mirlacher M, Sauter G, Dimhofer S (2004) Frequent EpCAM protein expression in human carcinomas. Hum Pathol 35:122–128

    Article  CAS  Google Scholar 

  28. Dou XQ, Li P, Jiang SY, Bayat H, Schönherr (2017) Bioinspired hierarchically structured surfaces for efficient capture and release of circulating tumor cells. ACS Appl Mater Interf 9: 8508–8518

    Google Scholar 

  29. Hou S, Zhao HC, Zhao LB, Shen QL, Wei KS, Suh DY, Nakao A, Garcia MA, Song M, Lee M, Xiong B, Luo SC, Tseng HR, Yu HH (2013) Capture and stimulated release of circulating tumor cells on polymer-grafted silicon nanostructures. Adv Mater 25:1547–1551

    Article  CAS  Google Scholar 

  30. Hou S, Zhao LB, Shen QL, Yu JH, Ng C, Kong XJ, Wu DX, Song M, Shi XH, Xu XC, OuYang WH, He RX, Zhao XZ, Lee T, Brunicardi FC, Garcia MA, Ribas A, Lo RS, Tseng HR (2013) Polymer nanofiber-embedded microchips for detection, isolation, and molecular analysis of single circulating melanoma cells. Angew Chem Int Ed 52:3379–3383

    Article  CAS  Google Scholar 

  31. Mahmood MAI, Wan Y, Islam M, Ali W, Hanif M, Kim YT, Iqbal SM (2014) Micro + Nanotexturing of substrates to enhance ligand-assisted cancer cell isolation. Nanotechnology 25:475102

    Article  Google Scholar 

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Correspondence to Chuanliang Feng .

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Feng, C., Dou, X., Xu, Y. (2021). Bioinspired Hierarchically Structured Polymer Interfaces for Promising Biomedical Applications. In: Microfabrication of Stimuli-Responsive Polymers. Springer, Singapore. https://doi.org/10.1007/978-981-33-6869-9_9

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